D-HISTIDINE
D-Histidine
CAS: 351-50-8
Molecular Formula: C6H9N3O2
D-HISTIDINE - Names and Identifiers
| Name | D-Histidine |
| Synonyms | D-HIS D-HIS-OH H-D-HIS-OH H-D-His-OH D-HISTIDINE D-Histidine HISTIDINE, D- D-Histidine hydrochloride D-2-AMINO-3-(4-IMIDAZOLYL)PROPIONIC ACID D-ALPHA-AMINO-BETA-IMIDAZOLEPROPIONIC ACID D-ALPHA-AMINO-BETA-(4-IMIDAZOLYL)PROPIONIC ACID |
| CAS | 351-50-8 |
| EINECS | 206-513-8 |
| InChI | InChI=1/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m1/s1 |
D-HISTIDINE - Physico-chemical Properties
| Molecular Formula | C6H9N3O2 |
| Molar Mass | 155.15 |
| Density | 1.3092 (rough estimate) |
| Melting Point | 280 °C |
| Boling Point | 278.95°C (rough estimate) |
| Specific Rotation(α) | -12 º (c=11, 6N HCl) |
| Flash Point | 231.3°C |
| Water Solubility | 42 g/L (25 ºC) |
| Solubility | 1 M HCl: soluble |
| Vapor Presure | 3.25E-09mmHg at 25°C |
| Appearance | White crystal |
| Color | White |
| Merck | 14,4720 |
| BRN | 84089 |
| pKa | 1.91±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | -13 ° (C=11, 6mol/L |
| MDL | MFCD00065963 |
| Physical and Chemical Properties | Melting Point: 254 |
D-HISTIDINE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37 - Wear suitable protective clothing and gloves. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29332900 |
D-HISTIDINE - Reference
| Reference Show more | 1. [IF=7.1] Haiyan Fu et al."Rational design of an “on-off-on” fluorescent assay for chiral amino acids based on quantum dots and nanoporphyrin."Sensor Actuat B-Chem. 2019 May;287:1 2. [IF=7.79] Ye Lu et al."Enhancing hydrogel-based long-lasting chemiluminescence by a platinum-metal organic framework and its application in array detection of pesticides and D-amino acids."Nanoscale. 2020 Feb;12(8):4959-4967 |
D-HISTIDINE - Standard
Authoritative Data Verified Data
This product is L-2-amino -3 -(lH-imidazole -4) propionic acid. Calculated as dried product, the content of C6H9N302 shall not be less than 99.0%.
Last Update：2024-01-02 23:10:35
D-HISTIDINE - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline or crystalline powder; Odorless.
- This product is dissolved in water, very slightly soluble in ethanol, insoluble in ether.
specific rotation
take this product, precision weighing, add 6mol/L hydrochloric acid solution to dissolve and quantitatively dilute to make about O in each lml. The llg solution was measured according to the law (General rule 0621), and the specific rotation was 12.0 ° to 12.8 °.
Last Update：2022-01-01 13:38:15
D-HISTIDINE - Differential diagnosis
Authoritative Data Verified Data
- a solution containing about 0.4mg per 1 ml was prepared by adding appropriate amounts of the product and the histidine reference, and then diluted with water, respectively, as the test solution and the reference solution. According to the chromatographic condition test under other amino acids, the position and color of the main spot of the test solution should be the same as that of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 981).
Last Update：2022-01-01 13:38:16
D-HISTIDINE - Exam
Authoritative Data Verified Data
pH
take l.Og of this product, add 50ml of water to dissolve, and measure it according to law (General rule 0631). The pH value should be 7.0~8.5.
transmittance of solution
take 0.60g of this product, add water 20ml to dissolve, according to UV-visible spectrophotometry (General rule 0401), measure the transmittance at 430nm wavelength, not less than 98.0%.
chloride
take 0.25g of this product and check it according to law (General rule 0801). Compared with the control solution made of 0.02% of standard sodium chloride solution, it should not be more concentrated ().
sulfate
take l.Og of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.02% of standard potassium sulfate solution, it should not be more concentrated ().
ammonium salt
take 0.10g of this product and check it according to law (General rule 0808). Compared with the control solution made of 0.02% of standard ammonium chloride solution, it shall not be deeper ().
other amino acids
take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 10 mg per lml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to scale with water, shake well, as a control solution; Take the appropriate amount of histidine reference and proline reference respectively, and place in the same measuring flask, water was added to dissolve and diluted to prepare a solution containing about 0.4mg each per 1ml as a system-suitable solution. According to the thin layer chromatography (General 0502) test, Draw 5 u1 of each of the above three solutions, respectively point on the same silica gel G thin layer plate, with N-propanol-concentrated ammonia solution (67:33) as the developing solvent, expand, dry, spray with ninhydrin in acetone solution (1-50), heat at 80°C until spots appear, and examine immediately. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. If the test solution shows impurity spots, the color should not be deeper (0.5%) than the main spot of the control solution.
loss on drying
take this product, dry at 105°C for 3 hours, loss of weight shall not exceed 0.2% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Iron Salt
take l.Og of this product and check it according to law (General rule 0807). Compared with the control solution made of 0.001% of standard iron solution, it shall not be deeper ().
Heavy metals
This product l.Og, inspection according to law (General Principles 0821 The first law), containing heavy metals shall not exceed 10 parts per million.
arsenic salt
take 2.0g of this product, add 23ml of water to dissolve, add 5ml of hydrochloric acid, check according to law (General rule 0822 first law), should comply with the provisions (0.0001%).
bacterial endotoxin
take this product, check according to law (General rule 1143), each lg histidine containing endotoxin should be less than 6.0EU. (For injection)
Last Update：2022-01-01 13:38:16
D-HISTIDINE - Content determination
Authoritative Data Verified Data
take this product about 0.15g, precision weighing, add anhydrous formic acid 2ml to dissolve, add glacial acetic acid 50ml, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml perchloric acid titration solution (0.1 mol/ L) corresponds to 15.52mg of C6H9N302.
Last Update：2022-01-01 13:38:17
D-HISTIDINE - Category
Authoritative Data Verified Data
amino acid drugs.
Last Update：2022-01-01 13:38:17
D-HISTIDINE - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 13:38:17
D-HISTIDINE - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | D-Histidine is the enantiomer of L-histidine (HY-N0832). L-histidine are essential amino acids for babies. L-histidine are inhibitors of mitochondrial glutamine transport. |
| target | Human Endogenous Metabolite |
Last Update：2024-04-09 20:52:54
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