CYBINAP

CYBINAP - Names and Identifiers

Name	(R)-(+)-2,2'-BIS(DICYCLOHEXYLPHOSPHINO)-1,1'-BINAPHTHYL
Synonyms	CYBINAP (S)-(-)-CYBINAP (R)-(+)-CYBINAP 2,2'-BIS(DICYCLOHEXYLPHOSPHINO)-1,1'-BINAPHTHYL (R)-(+)-2,2'-BIS(DICYCLOHEXYLPHOSPHINO)-1,1'-BINAPHTHYL (S)-(-)-2,2'-BIS(DICYCLOHEXYLPHOSPHINO)-1,1'-BINAPHTHYL 1,1'-(1R)-[1,1'-Binaphthalene]-2,2'-diylbis[1,1-dicyclohexyl]-phosphine Phosphine, 1,1'-[(1R)-[1,1'-binaphthalene]-2,2'-diyl]bis[1,1-dicyclohexyl-
CAS	139139-92-7

CYBINAP - Physico-chemical Properties

Molecular Formula	C44H56P2
Molar Mass	646.86

CYBINAP - Introduction

(R)-( )-2,2 '-BIS(DICYCLOHEXYLPHOSPHINO)-1,1'-BINAPHTHYL is a chiral phosphine ligand, often called (R)-( )-2,2 '-BIS(DICYCLOHEXYLPHOSPHINO)-1,1'-BINAPHTHYL. It has the following properties:

1. Appearance: colorless crystal or white powder.
2. Molecular formula: C44H52P2
3. Molecular weight: 634.87g/mol
4. Melting Point: 225 ° C- 227 ° C
5. Solubility: Soluble in organic solvents.

This ligand is widely used in metal organic catalytic reactions, including:

1. Chiral drug synthesis: as an asymmetric catalyst for the synthesis of chiral drugs or similar compounds.
2. Asymmetric hydrogenation reaction: Used in asymmetric hydrogenation reaction, such as asymmetric synthesis of Aliphatic Ketones and alcohols and other organic block compounds.
3. Redox catalytic reactions: In catalytic reduction and oxidation reactions, various effective chiral ligands have been developed.

This chiral ligand can be prepared by the following steps:

1. First, the important intermediate (R)-BINOL is obtained by the reaction of boron iodide with phenylborate.
2. Using trifluoromethanesulfonic acid as an acid catalyst, the two hydroxyl groups of (R)-BINOL were protected as triethylsilyl groups.
3. Using zinc chloride as a catalyst, the phosphine group is introduced into the two positions of (R)-BINOL to obtain the desired ligand.

Regarding safety information, this compound is generally used as a catalyst when used in catalytic reactions, so the following matters need to be noted:

1. Avoid direct contact with skin and eyes. If contact, rinse with plenty of water immediately and seek medical advice.
2. During the operation, you should avoid inhaling dust or solution vapor. In order to protect the respiratory system, you can take appropriate protective measures, such as wearing a mask.
3. Storage should be placed in a cool, dry place, away from the fire and oxidant.

These are general safety information, but specific safety operation details need to refer to the relevant safety manual and Material Safety Data Sheet. Before using this compound, please ensure that you have appropriate chemical laboratory knowledge and skills and strictly follow laboratory safety procedures.

Last Update：2024-04-09 21:21:28