CS-950
IOWH032
CAS: 1191252-49-9
Molecular Formula: C22H15Br2N3O4
CS-950 - Names and Identifiers
CS-950 - Physico-chemical Properties
| Molecular Formula | C22H15Br2N3O4 |
| Molar Mass | 545.18 |
| Density | 1.670±0.06 g/cm3(Predicted) |
| Solubility | DMSO 100 mg/mL (183.42 mM); Water <1 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM) |
| pKa | 3.34±0.46(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD25977119 |
| In vitro study | In a cell-related assay T84-CFTR, IOWH032 showed inhibitory activity against CFTR with an IC50 of 6.87 μm. in a cell-related assay T84-CFTR, iow032 showed inhibitory activity against CFTR with an IC50 of 6.87 μm. |
| In vivo study | IOWH032 produced a statistically significant inhibition of cholera toxin (CTX)-induced secretions in a mouse closed system model. In a rat model in which the cecum was excised, iow032 (5 mg/kg) reduced fecal excretion by-70%. iow032 produced a statistically significant inhibition of cholera toxin (CTX)-induced secretions in a mouse closed system model. In a rat model in which the cecum was excised, iow032 (5 mg/kg) reduced fecal excretion by-70%. |
CS-950 - Introduction
IOWH032 is a synthetic CFTR inhibitor with an IC50 of 1.01 μM in CHO-CFTR cell assays. Phase 2.
Last Update：2022-10-16 17:41:18
CS-950 - Reference Information
| biological activity | IOWH032 is a synthetic CFTR inhibitor. in CHO-CFTR cell assay, IC50 is 1.01 μM. Phase 2. IOWH032 is a synthetic CFTR inhibitor. in CHO-CFTR cell assay, IC50 is 1.01 μM. Phase 2. |
| in vitro study | in T84-CFTR cell-related tests, IOWH032 showed inhibitory activity against CFTR with IC50 of 6.87 μM. in T84-CFTR cell related tests, IOWH032 showed inhibitory activity on CFTR with IC50 of 6.87 μM. |
| in vivo study | in the mouse closed system model, IOWH032 produced a statistically significant inhibition of secretion induced by cholera toxin (CTX). In a rat model with caecum resection, IOWH032 (5 mg/kg) reduced ~ 70% excreta excretion. in the mouse closed system model, IOWH032 produced a statistically significant inhibition of secretion induced by cholera toxin (CTX). In a rat model with caecum resection, IOWH032 (5 mg/kg) reduced ~ 70% excreta excretion. |
| target | TargetValue CFTR 1.01 μM |
| Target | Value |
| CFTR | 1.01 μM |
Last Update：2024-04-09 20:52:54
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