CS-510
(E)-1-[(1S)-1-(4-Fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]piperidin-2-one
CAS: 870843-42-8
Molecular Formula: C25H26FN3O2
CS-510 - Names and Identifiers
CS-510 - Physico-chemical Properties
| Molecular Formula | C25H26FN3O2 |
| Molar Mass | 419.49 |
| Density | 1.19±0.1 g/cm3(Predicted) |
| Boling Point | 649.2±55.0 °C(Predicted) |
| pKa | 5.67±0.61(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | E2012 has concentration-dependent inhibitory effects on cholesterol biosynthesis in primary culture of rat hepatocytes and HepG2 cells with IC 50 s of 11.0, and 15.1 nM, respectively. |
| In vivo study | In vivo lenticular concentration of E 2012 after 13-week repeated dose with cataract was well above those where inhibition is observed in vitro. E 2012 induces cataract in the rat by inhibiting DHCR24 at the final step of cholesterol synthesis with associated elevation in desmosterol within the lens, preceded by desmosterol changes that would serve as a predictive safety biomarker for lenticular opacity. |
CS-510 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.384 ml | 11.919 ml | 23.838 ml |
| 5 mM | 0.477 ml | 2.384 ml | 4.768 ml |
| 10 mM | 0.238 ml | 1.192 ml | 2.384 ml |
| 5 mM | 0.048 ml | 0.238 ml | 0.477 ml |
Last Update：2024-01-02 23:10:35
CS-510 - Reference Information
| biological activity | E 2012 is an effective gamma secretase regulator and will not affect Notch processing. E 2012 inhibits 3 β-hydroxysterol Δ24-reductase (DHCR24) in the last step of cholesterol biosynthesis. E 2012 was designed to reduce Alzheimer's disease by reducing amyloid β-42 and to induce cataracts after repeated dosing in rats. |
| in vitro study | E2012 has concentration-dependent inhibitory effects on cholesterol biosynthesis in primary culture of rat hepatocytes and HepG2 cells with IC 50 s of 11.0, and 15.1 nM, respectively. |
| in vivo research | in vivo lenticular concentration of E 2012 after 13-week repeated dose with cataract was well above where inhibition is observed in vitro. E 2012 induces cataract in the rat by inhibiting DHCR24 at the final step of cholesterol synthesis with associated elevation in desmosterol within the lens, preceded by desmosterol changes that would serve as a predictive safety biomarker for lenticular opacity. |
Last Update：2024-04-09 15:16:39
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Product Name: E-2012 Visit Supplier Webpage Request for quotationCAS: 870843-42-8
Tel: +86-18821248368
Email: Int06@meryer.com
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Product Name: E-2012 Request for quotationCAS: 870843-42-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Multiple SpecificationsSpot supply
Product Name: E 2012 (Standard) Visit Supplier Webpage Request for quotationCAS: 870843-42-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: E 2012 Visit Supplier Webpage Request for quotationCAS: 870843-42-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: (E)-1-[(1S)-1-(4-Fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]piperidin-2-one Visit Supplier Webpage Request for quotation
CAS: 870843-42-8
Tel: 18301782025
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Mobile: 18021002903
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CAS: 870843-42-8
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View History
CS-510
DICHLOROBIS(TRIETHYLPHOSPHINE)PLATINUM (II)
C.I. Pigment Yellow 126
RARECHEM AK ML 0105
Ketoleucine Potassium salt
DICHLOROBIS(TRIETHYLPHOSPHINE)PLATINUM (II)
C.I. Pigment Yellow 126
RARECHEM AK ML 0105
Ketoleucine Potassium salt