CS-1829
HPOB
CAS: 1429651-50-2
Molecular Formula: C17H18N2O4
CS-1829 - Names and Identifiers
CS-1829 - Physico-chemical Properties
| Molecular Formula | C17H18N2O4 |
| Molar Mass | 314.34 |
| Solubility | 10 mM in DMSO |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | 2-8°C |
| In vitro study | In normal (HFS) and transformed (LNCaP, A549, and U87) cells, HPOB induces acetylation of α-tubulin, however, not histones, and inhibits cell growth, however, not viability. In HFS cells, HPOB enhances transformed cell death induced by etoposide, doxorubicin, or SAHA. HPOB also enhancing etoposide-induced transformed cell death via the apoptotic pathway in transformed cells. |
| In vivo study | In mice bearing CWR22 human prostate cancer xenografts, HPOB (300 mg/kg/d i.p.), when in combination with SAHA, causes suppression of the growth of established tumors, while produces no significant suppression when used alone. |
CS-1829 - Risk and Safety
| WGK Germany | 3 |
CS-1829 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.181 ml | 15.907 ml | 31.813 ml |
| 5 mM | 0.636 ml | 3.181 ml | 6.363 ml |
| 10 mM | 0.318 ml | 1.591 ml | 3.181 ml |
| 5 mM | 0.064 ml | 0.318 ml | 0.636 ml |
Last Update：2024-01-02 23:10:35
CS-1829 - Reference Information
| biological activity | HPOB is an effective, selective HDAC6 inhibitor with IC50 of 56 nM, which is more than 30 times higher than other HDACs. |
| in vitro study | in normal (HFS) and transformed (LNCaP, A549, and U87) cells, HPOB induces acetylation of α-tubulin, however, not histones, and inhibits cell growth, however, not viability. In HFS cells, HPOB enhances transformed cell death induced by etoposide, doxorubicin, or SAHA. HPOB also enhancing etoposide-induced transformed cell death via the apoptotic pathway in transformed cells. |
| in vivo research | in mice bearing CWR22 human prostate cancer xenografts, HPOB (300 mg/kg/d I. p.), when in combination with SAHA, uses suppression of the growth of established tumors, while produces no significant suppression when used alone. |
Last Update：2024-04-09 15:16:38
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