CS-1475
SGC-0946
CAS: 1561178-17-3
Molecular Formula: C28H40BrN7O4
CS-1475 - Names and Identifiers
CS-1475 - Physico-chemical Properties
| Molecular Formula | C28H40BrN7O4 |
| Molar Mass | 618.57 |
| Density | 1.48±0.1 g/cm3(Predicted) |
| Melting Point | 125-126o C |
| Boling Point | 771.5±60.0 °C(Predicted) |
| Solubility | DMSO: soluble20mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| pKa | 12.39±0.70(Predicted) |
| Storage Condition | -20°C |
| In vitro study | SGC 0946 is 100-fold more selective than other histone methyltransferases/HMTs. SGC 0946 acts on A431 cells and MCF10A cells, effectively reducing H3K79 dimethylation with IC50 of 2.6 nM and 8.8 nM, respectively, and effectively and selectively kills cells containing MLL translocation. SGC 0946 is more potent than its analog EPZ004777 and serves as an excellent chemical probe for the Study of DOT1L, and further studies of the use of DOT1L inhibitors for cancer treatment. SGC 0946 is 100-fold more selective than other histone methyltransferases/HMTs. SGC 0946 acts on A431 cells and MCF10A cells, effectively reducing H3K79 dimethylation with IC50 of 2.6 nM and 8.8 nM, respectively, and effectively and selectively kills cells containing MLL translocation. SGC 0946 is more potent than its analog EPZ004777 and serves as an excellent chemical probe for the Study of DOT1L, and further studies of the use of DOT1L inhibitors for cancer treatment. |
CS-1475 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
CS-1475 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.617 ml | 8.083 ml | 16.166 ml |
| 5 mM | 0.323 ml | 1.617 ml | 3.233 ml |
| 10 mM | 0.162 ml | 0.808 ml | 1.617 ml |
| 5 mM | 0.032 ml | 0.162 ml | 0.323 ml |
Last Update：2024-01-02 23:10:35
CS-1475 - Reference Information
| biological activity | SGC 0946 is a potent, selective DOT1L methyltransferase inhibitor with an IC50 of 0.3 nM, inhibition of 12 PMTs and DNMT1 activity. SGC 0946 is a potent, selective DOT1L methyltransferase inhibitor with an IC50 of 0.3 nM in a cell-free assay and no activity on a series of 12 PMTs and DNMT1. |
| in vitro study | SGC 0946 is 100-fold more selective than other histone methyltransferases/HMTs. SGC 0946 acts on A431 cells and MCF10A cells, effectively reducing H3K79 dimethylation with IC50 of 2.6 nM and 8.8 nM, respectively, and effectively and selectively kills cells containing MLL translocation. SGC 0946 is more potent than its analog EPZ004777 and serves as an excellent chemical probe for the Study of DOT1L, and further studies of the use of DOT1L inhibitors for cancer treatment. SGC 0946 is 100-fold more selective than other histone methyltransferases/HMTs. SGC 0946 acts on A431 cells and MCF10A cells, effectively reducing H3K79 dimethylation with IC50 of 2.6 nM and 8.8 nM, respectively, and effectively and selectively kills cells containing MLL translocation. SGC 0946 is more potent than its analog EPZ004777 and serves as an excellent chemical probe for the Study of DOT1L, and further studies of the use of DOT1L inhibitors for cancer treatment. |
| features | Cell-active DOT1L-selective chemical probe. |
| Target | TargetValue DOT1L (Cell-free assay) 0.3 nM |
| Target | Value |
| DOT1L (Cell-free assay) | 0.3 nM |
Last Update：2024-04-09 20:52:54
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Featured ProductsSpot supply
Product Name: SGC-0946 Visit Supplier Webpage Request for quotationCAS: 1561178-17-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: SGC0946 Request for quotationCAS: 1561178-17-3
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: SGC0946 Visit Supplier Webpage Request for quotationCAS: 1561178-17-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: SGC0946 Visit Supplier Webpage Request for quotationCAS: 1561178-17-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SGC-0946 Visit Supplier Webpage Request for quotationCAS: 1561178-17-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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