CS-1463
1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol
CAS: 301353-96-8
Molecular Formula: C21H18Br2N2O
CS-1463 - Names and Identifiers
CS-1463 - Physico-chemical Properties
| Molecular Formula | C21H18Br2N2O |
| Molar Mass | 474.19 |
| Density | 1.61±0.1 g/cm3(Predicted) |
| Boling Point | 656.4±55.0 °C(Predicted) |
| Solubility | DMSO: soluble34mg/mL |
| Appearance | powder |
| Color | white to off-white |
| pKa | 13.91±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months |
| MDL | MFCD00572918 |
| In vitro study | In U2OS cells, P7C3 protects cells from doxorubicin-mediated toxicity and increases nicotinamide flux through a NAMPT-mediated salvage pathway. |
| In vivo study | In the mouse brain, P7C3 (40 mg/kg, p.o.) induces neurogenesis and enhances the survival of newborn neurons. In npas3 in the Down syndrome Ts65Dn mouse model, P7C3 restores hippocampal neurogenesis by significantly increasing total Ki67 ,DCX, and viable BrdU cells. |
CS-1463 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
CS-1463 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.109 ml | 10.544 ml | 21.088 ml |
| 5 mM | 0.422 ml | 2.109 ml | 4.218 ml |
| 10 mM | 0.211 ml | 1.054 ml | 2.109 ml |
| 5 mM | 0.042 ml | 0.211 ml | 0.422 ml |
Last Update：2024-01-02 23:10:35
CS-1463 - Reference Information
| biological activity | P7C3 is an effective neurogenic and neuroprotective chemical that targets NAMPT enzyme. |
| target | TargetValue NAMPT () |
| Target | Value |
| In vitro study | In U2OS cells, P7C3 protects the cells from doxorubicin-mediated toxicity and increases nicotinamide flow through NAMPT-mediated remediation. |
| in vivo study | in mouse brain, P7C3 (40 mg/kg, p.o.) induces neurogenesis and enhances the survival of newborn neurons. In npas3 in a Down syndrome Ts65Dn mouse model, P7C3 restored hippocampal neurogenesis by significantly increasing total Ki67 ,DCX, and surviving BrdU cells. |
Last Update：2024-04-09 15:16:36
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