CPI-455
CPI-455； 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
CAS: 1628208-23-0
Molecular Formula: C16H14N4O
CPI-455 - Names and Identifiers
CPI-455 - Physico-chemical Properties
| Molecular Formula | C16H14N4O |
| Molar Mass | 278.31 |
| Density | 1.28±0.1 g/cm3(Predicted) |
| Boling Point | 488.7±55.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| Appearance | solid |
| Color | Off-white |
| pKa | -5.10±0.60(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Use | CPI-455 is a specific pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A, CPI-455 mediates KDM5 inhibition, improves the overall level of H3K4me3, and reduces the number of drug-resistant persistent cancer cells in a multi-tumor cell line model. |
CPI-455 - Reference
| Reference Show more | 1: Vinogradova M, Gehling VS, Gustafson A, Arora S, Tindell CA, Wilson C, Williamson KE, Guler GD, Gangurde P, Manieri W, Busby J, Flynn EM, Lan F, Kim HJ, Odate S, Cochran AG, Liu Y, Wongchenko M, Yang Y, Cheung TK, Maile TM, Lau T, Costa M, Hegde GV, Jackson E, Pitti R, Arnott D, Bailey C, Bellon S, Cummings RT, Albrecht BK, Harmange JC, Kiefer JR, Trojer P, Classon M. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12(7):531-8. doi: 10.1038/nchembio.2085. PubMed PMID: 27214401. |
CPI-455 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.593 ml | 17.966 ml | 35.931 ml |
| 5 mM | 0.719 ml | 3.593 ml | 7.186 ml |
| 10 mM | 0.359 ml | 1.797 ml | 3.593 ml |
| 5 mM | 0.072 ml | 0.359 ml | 0.719 ml |
Last Update：2024-01-02 23:10:35
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Product Name: 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile Request for quotationCAS: 1628208-23-0
Tel: 400-968-2212
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Mobile: 18916960931
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Product Name: CPI-455 Visit Supplier Webpage Request for quotationCAS: 1628208-23-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: CPI-455 (Standard) Visit Supplier Webpage Request for quotationCAS: 1628208-23-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: CPI-455 Visit Supplier Webpage Request for quotationCAS: 1628208-23-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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Spot supply
Product Name: CPI-455； 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile Visit Supplier Webpage Request for quotationCAS: 1628208-23-0
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View History
CPI-455
443-75-4
Furoxone
97-87-0
硝酸钙
Triethyl tin bromide
n-formylaniline
71-90-9
Isopropyl phosphonate
620-52-0
443-75-4
Furoxone
97-87-0
硝酸钙
Triethyl tin bromide
n-formylaniline
71-90-9
Isopropyl phosphonate
620-52-0