CL-387785
CL-387785
CAS: 194423-06-8
Molecular Formula: C18H13BrN4O
CL-387785 - Names and Identifiers
CL-387785 - Physico-chemical Properties
| Molecular Formula | C18H13BrN4O |
| Molar Mass | 381.23 |
| Density | 1.577±0.06 g/cm3(Predicted) |
| Melting Point | 276 °C |
| Solubility | DMSO: 13.67 mg/mL |
| Appearance | Off-white to yellow solid. |
| pKa | 9.84±0.43(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | CL-387785 blocks EGF-mediated receptor autophosphorylation in cells with an IC50 value of 5 nM. Of the cell lines that overexpressed EGF-R or c-erbB-2, CL-387785 inhibited cell proliferation predominantly as a cytostatic with an IC50 value of 31 nM. |
| In vivo study | In nude mice overexpressing EGF-R, CL-387785(80 mg/kg/day, P. O.) effectively inhibited tumor growth. In the autosomal recessive polycystic kidney disease mouse model (ARPKD), Balb/EKI-785/bpk (BPK) mice were treated with c-bpk (90 mg/kg, I. P.), can significantly reduce the collection of tubular cystic lesions, improve renal function, reduce bile duct epithelial cell abnormalities, prolong survival. The EKI-785 dose as low as 25 mg/kg was able to reduce the xenograft tumor growth induced by HCA-7, and the dose of 100 mg/kg completely inhibited tumor growth. CL-387785 at 50 mg/kg was effective in inhibiting HCT-116 of the induced xenograft growth. |
CL-387785 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.623 ml | 13.116 ml | 26.231 ml |
| 5 mM | 0.525 ml | 2.623 ml | 5.246 ml |
| 10 mM | 0.262 ml | 1.312 ml | 2.623 ml |
| 5 mM | 0.052 ml | 0.262 ml | 0.525 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Featured ProductsSpot supply
Product Name: CL-387785 Visit Supplier Webpage Request for quotationCAS: 194423-06-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: CL-387785 Request for quotationCAS: 194423-06-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: CL-387785 Visit Supplier Webpage Request for quotationCAS: 194423-06-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: EKI-785; WAY-EKI 785 Visit Supplier Webpage Request for quotationCAS: 194423-06-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: CL-387785 Visit Supplier Webpage Request for quotationCAS: 194423-06-8
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: CL-387785 Visit Supplier Webpage Request for quotationCAS: 194423-06-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: CL-387785 Visit Supplier Webpage Request for quotationCAS: 194423-06-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: CL-387785 Request for quotationCAS: 194423-06-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: CL-387785 Visit Supplier Webpage Request for quotationCAS: 194423-06-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: EKI-785; WAY-EKI 785 Visit Supplier Webpage Request for quotationCAS: 194423-06-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: CL-387785 Visit Supplier Webpage Request for quotationCAS: 194423-06-8
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: CL-387785 Visit Supplier Webpage Request for quotationCAS: 194423-06-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History