CIS-10-CIS-12-CONJUGATEDLINOLEICACID
Conjugated linoleic acid
CAS: 2420-56-6;121250-47-3
Molecular Formula: C18H32O2
CIS-10-CIS-12-CONJUGATEDLINOLEICACID - Names and Identifiers
CIS-10-CIS-12-CONJUGATEDLINOLEICACID - Physico-chemical Properties
| Molecular Formula | C18H32O2 |
| Molar Mass | 280.45 |
| Density | 0.911±0.06 g/cm3(Predicted) |
| Boling Point | 377.7±11.0 °C(Predicted) |
| Flash Point | 14℃ |
| Vapor Presure | 9.54E-07mmHg at 25°C |
| pKa | 4.78±0.10(Predicted) |
| Storage Condition | −20°C |
| Refractive Index | 1.478 |
CIS-10-CIS-12-CONJUGATEDLINOLEICACID - Risk and Safety
| Risk Codes | R11 - Highly Flammable R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R39/23/24/25 - |
| Safety Description | S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1170 3/PG 2 -Ethanol,solution |
CIS-10-CIS-12-CONJUGATEDLINOLEICACID - Reference Information
| Introduction | Conjugated linoleic acid (Conjugatedlinoleicacid, hereinafter referred to as CLA) is an octadecadienoic acid containing cis or trans-conjugated double bonds. It is a group of positions and conformational isomers of linoleic acid. It has many functions such as inhibiting the formation of cancer and tumors, losing weight, resisting atherosclerosis, improving immune function, lowering cholesterol, and promoting growth, it is a new type of functional grease. |
| physiology | 1. anticancer effect conjugated linoleic acid can inhibit proliferation, nuclear division, colony formation and cell DNA synthesis of human gastric adenocarcinoma cells (SGC-7901), and can induce differentiation of SGC-7901 cells. 2. anti-atherosclerosis high cholesterol concentration in blood is the main cause of atherosclerosis. CLA can effectively inhibit the occurrence of arteriosclerosis and cause partial regression of the formed arteriosclerosis. 3. enhance the body's immune ability CLA can promote cell division, prevent muscle degeneration and delay the decline of the body's immune ability. CLA is involved in the regulation of the immune system, strengthening the mitogen-induced lymphocyte blast-like transformation, lymphocyte virulence and macrophage killing. 4. improving the quality of meat CLA can effectively inhibit the oxidation of myosin during frozen storage of pork, but has no effect on meat color. 5. involved in lipolysis and metabolism CLA can reduce body fat, especially abdominal fat, but the body weight remains unchanged. CLA can inhibit fat deposition and improve lean meat rate, which is caused by inhibiting fat synthesis and strengthening lipolysis of adipose tissue. CLA reduces body fat by reducing feed intake, increasing metabolic rate and reducing nocturnal respiration. 6. Improving bone tissue metabolism CLA can promote the division and regeneration of bone tissue, promote the synthesis of cartilage tissue cells and the deposition of minerals in bone tissue, and has a positive effect on bone health. This may be the result of regulating the concentration of PGE2. Excessive concentration of PGE2 can inhibit the synthesis of bone, while CLA can effectively reduce the concentration of PGE2, thus promoting the formation of bone. 7. Anti-mildew effect The sodium salt and potassium salt of CLA can inhibit the growth of mold, and has no toxic and side effects. It is relatively stable in nature and has no upper limit of use. It can be used in food, cosmetics and other industries and can be used as a substitute for sodium benzoate. |
| source | 1. naturally occurring natural CLA mainly exists in the milk fat and meat products of rumen animals such as cattle and sheep. the content of CLA varies from 2 to 25mg per gram of milk fat, and the content of CLA increases with the age of dairy cows. The formation of CLA is due to the anaerobic linoleic acid isomerase of Vibrio fibrobutyrate in ruminant intestines, which can convert linoleic acid into CLA, and mainly into biologically active cis-9,trans-11 isomers. CLA is also found in small amounts in tissues, blood and body fluids of other animals. CLA is also found in human milk. 2. Artificial synthesis Using linoleic acid or linoleic acid-rich vegetable oil as substrate, CLA can be synthesized through base-catalyzed isomerization reaction. The initial synthetic CLA is a mixture of multiple isomers, mainly containing cis-trans, trans-cis isomers and a small amount of cis-cis and trans-trans isomers. The improved synthesis process can make CLA more purified, cis-9 the content of trans-11, trnas-10 and cis-12 isomers exceeds 50%, and non-CLA components are less than 1%. At present, there are mainly the following synthetic methods. |
Last Update：2024-04-09 15:16:49
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