CCS-1477
(S)-1-(3,4-difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-((1r,4S)-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)piperidin-2-one
CAS: 2222941-37-7
Molecular Formula: C30H32F2N4O3
CCS-1477 - Names and Identifiers
CCS-1477 - Physico-chemical Properties
| Molecular Formula | C30H32F2N4O3 |
| Molar Mass | 534.6 |
| Density | 1.37±0.1 g/cm3(Predicted) |
| Boling Point | 761.0±60.0 °C(Predicted) |
| Solubility | DMSO : 80 mg/mL mother liquor preservation: sub-package and freeze storage to avoid repeated freezing and thawing;-20 ℃,1 month;-80 ℃,6 months (after dilution, the solution temperature is low, storage may precipitate, try to use it now) |
| pKa | 4.40±0.10(Predicted) |
| Storage Condition | -20℃ |
| Use | Inobrodib (CCS1477) is an orally active, effective and selective p300/CBP inhibitor. Inobrodib combined with p300 and CBP, Kd values are 1.3 and 1.7 nM, which has a 170/130-fold selectivity compared with BRD4 with Kd of 222 nM. Inobrodib inhibit cell proliferation and decrease androgen receptor (AR) and C- MYC-regulated gene expression in prostate cancer cell lines. |
| Target | p300/CBP |
CCS-1477 - Reference
| Reference Show more | 1: Rasool RU, Natesan R, Asangani IA. Toppling the HAT to Treat Lethal Prostate Cancer. Cancer Discov. 2021 May;11(5):1011-1013. doi: 10.1158/2159-8290.CD-21-0184. PMID: 33947717. 2: Welti J, Sharp A, Brooks N, Yuan W, McNair C, Chand SN, Pal A, Figueiredo I, Riisnaes R, Gurel B, Rekowski J, Bogdan D, West W, Young B, Raja M, Prosser A, Lane J, Thomson S, Worthington J, Onions S, Shannon J, Paoletta S, Brown R, Smyth D, Harbottle GW, Gil VS, Miranda S, Crespo M, Ferreira A, Pereira R, Tunariu N, Carreira S, Neeb AJ, Ning J, Swain A, Taddei D; SU2C/PCF International Prostate Cancer Dream Team, Schiewer MJ, Knudsen KE, Pegg N, de Bono JS. Targeting the p300/CBP Axis in Lethal Prostate Cancer. Cancer Discov. 2021 May;11(5):1118-1137. doi: 10.1158/2159-8290.CD-20-0751. Epub 2021 Jan 11. PMID: 33431496; PMCID: PMC8102310. 3: He ZX, Wei BF, Zhang X, Gong YP, Ma LY, Zhao W. Current development of CBP/p300 inhibitors in the last decade. Eur J Med Chem. 2021 Jan 1;209:112861. doi: 10.1016/j.ejmech.2020.112861. Epub 2020 Oct 1. PMID: 33045661. |
CCS-1477 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.871 ml | 9.353 ml | 18.705 ml |
| 5 mM | 0.374 ml | 1.871 ml | 3.741 ml |
| 10 mM | 0.187 ml | 0.935 ml | 1.871 ml |
| 5 mM | 0.037 ml | 0.187 ml | 0.374 ml |
Last Update：2024-01-02 23:10:35
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View History
CCS-1477
Phenobarbital SodiuM API
H-89 DIHYDROCHLORIDE
環烷酸銅
Tofacitinib Impurity 2
147149-98-2
Chromium nitride
108282-38-8
176508-81-9
210110-90-0
Phenobarbital SodiuM API
H-89 DIHYDROCHLORIDE
環烷酸銅
Tofacitinib Impurity 2
147149-98-2
Chromium nitride
108282-38-8
176508-81-9
210110-90-0