CARRAGEENAN
CARRAGEENAN
CAS: 9000-07-1
Molecular Formula:
CARRAGEENAN - Names and Identifiers
| Name | CARRAGEENAN |
| Synonyms | aubygelgs CARRAGEENAN 3,6-anhydro-d-galactan |
| CAS | 9000-07-1 |
| EINECS | 232-524-2 |
CARRAGEENAN - Physico-chemical Properties
| Appearance | White or yellowish powder |
| Storage Condition | Room Temprature |
| MDL | MFCD00081480 |
| Physical and Chemical Properties | Properties carrageenan has the basic characteristics of soluble dietary fiber. After degradation in vivo, carrageenan can form a soluble complex with fibrin. It can be glycolized into CO2, H2, biogas and short chain fatty acids such as formic acid, acetic acid and propionic acid by large intestine bacteria, and become an energy source of probiotics. |
| Use | Use thickener; Stabilizer; Emulsifier; Suspending agent; Gelling agent; Binder. |
CARRAGEENAN - Reference
| Reference Show more | 1. Zhang Yunhan, Liu Li, Tao Hui, Chen Yong, Ge Jian. Study on anticoagulant activity of a new drug QR02001, class 1.1, in vivo [J]. Journal of Hubei University (Natural Science Edition) 2015 37(04):322-326. 2. Chen Jiangfeng, Zhao Jiwei, Xiao Huichang, et al. Effects of adding different coagulants to artificial feed on growth and development of Rhododendron decidua [J]. Gansu Agricultural Science and Technology 2020 No.529(01):18-22. 3. Su Huazhen, Tang xiuneng, Wei Jianggen, et al. Study on anti-inflammatory effect and mechanism of three point gold extract of lobular [J]. China Pharmacy, 2019, v.30;No.660(18):89-93. 4. Jiang Xue Cheng, Zhi Shu Tang, Jun Shi, et al. Effect of Angelica sinensis and Radix Paeoniae rubra compatibility on rats with heat-toxin and blood stasis syndrome [J]. Chinese Journal of Modern Applied Pharmacy, 36(23). 5. Li Zhiming, Zhou Chenglin, Zhong Rui, etc. Preparation and properties of gelatin-based antibacterial films [J]. Agricultural products processing, 2020, No.503(09):10-12. 6. Ren Shouzhong, Liang Xian, Su Wenqin, etc. Study on material basis of anti-inflammatory and antidiarrheal effects of extracts from Polygonum Bunge [J]. Shi Zhen, Chinese medicine, 2016, 027(001):32-34. 7. Ren Shouzhong, Su Wenqin, Chen Jun, etc. Study on anti-inflammatory effect and mechanism of extract of Polygonum Makino [J]. Pharmacology and Clinic of Traditional Chinese Medicine, 2016, v.32;No.181(01):160-163. 8. Huang zhuojian, Wang Zhiping, Xia Xing, etc. Preliminary Study on anti-inflammatory mechanism of extracts from root of white dorsal root [J]. Journal of Guangxi University of Chinese Medicine, 2014, 17(001):81-83. 9. Wan Kaihua, Zhao Yuan, Jiao Min, et al. Study on anti-inflammatory mechanism and acute toxicity of shikonin Sanhuang suppository [J]. Journal of Xinjiang Medical University, 2018, 41(10):112-115. 10. Jiang Sisi, Ma Wenna, Lu Wenjie, Ma Guizhi. Preliminary Screening of anti-inflammatory activity of the Uygur medicine Capparis spinosa fruit [J]. Chinese Journal of Experimental prescriptions, 2015,21(04):144-148. 11. Liang Weihai, Huang Peng, Li Lun, etc. Study on anti-inflammatory effect of eucalyptus bitter skin rash gel [J]. Shi Zhen, Chinese medicine, 2015, v.26;No.244(12):46-47. 12. Wang Shu, Zhou Dandan, Gong Xiaomei, etc. Anti-inflammatory effect and mechanism of petroleum ether extract from watermelon vine [J]. World Science and Technology-modernization of traditional Chinese medicine, 2014(9):2054-2059. 13. Xue Yan, Liu Xinyuan, Gao Hongbo, et al. Study on the mechanism of long leaf red sand in the treatment of eczema and dermatitis [J]. Pharmacology and Clinic of traditional Chinese medicine, 2017, 033(003):120-123. 14. Wang Xiaoming, Xu Liangkui, Luo Jiabo. Anti-inflammatory and analgesic effects of Herba ephedrae and Ramulus cinnamomi [J]. Chinese new drugs and clinical pharmacology, 2020, 29 (2):179-184. 15. Wang Xiaoming, Xu Liangkui, Luo Jiabo. Effect and mechanism of compatibility of ephedra and Ramulus cinnamomi on anti-inflammatory effect [J]. Shi Zhen, National Medicine, 2020, 3 (in Chinese):528-531. 16. Tang Yunli, Liu Junjun, Pan cuiliu, etc. Comparison of anti-inflammatory activity of four polar parts of the root of paulownia chinense [J]. Chinese traditional medicines, 2019, 41(03):663-668. 17. Liu Yuelu, Li Feng, Mo Xiaodong, etc. Study on the correlation between the effect of "detoxification and Analgesia" and the quality of toad venom [J]. Liaoning Journal of Traditional Chinese Medicine, 2017(05):1025-1028. 18. Yang Xinbiao, Zheng Mingzhu, Ren Yuhang, et al. Optimization of formula of traditional sticky bean bag based on hydrophilic colloid modification and mixture design [J]. Journal of Food Safety and quality testing, 2019, 010(020):6837-6842. 19. Zhang Yanyan, Wang Wentao, Zhang Zhongyi, et al. Effect of ultrasonic wave combined with cryoprotectant on water holding capacity and texture of quick-frozen noodle [J]. Science and Technology of food industry, 2020, v.41;No.451(11):7-12. 20. Cheng, Pan, Si. Preparation and stability of naringin nano-emulsion system [J]. Journal of Huazhong Agricultural University, 2019(4). 21. Zhang Zhongyi, Chai Ying, Fan Wen, etc. Improvement of anti-freezing performance of soybean protein isolate on quick-frozen meat filling [J]. Food industry, 2018, 039(001):30-34. 22. Che Biqi, ailenzhong, Xia Yongjun, etc. Effect of Streptococcus thermophilus exopolysaccharide EPS333 on quality of yogurt [J]. Industrial Microbiology, 2019, 49(02):29-35. 23. Liu Haiyun, Wang Wei-Min, Min Su-hua, et al. Isolation and purification of fucoidan from Sargassum and its effect on black-tailed thrombus in mice [J]. Food Science, 2020, v.41;No.622(09):100-106. 24. Cao Junjie. Study on safety and pharmacodynamics of huatan Zhike powder [D]. Jilin University, 2020. 25. Liu G. Study on quality evaluation of Panax notoginseng from different habitats [D]. Beijing University of Chinese Medicine, 2020. 26. Tang Yunli, Liu Junjun, Xie Haiyu, Qin Zujie, Europe and he, Zhang Guifang, Xu Shengmei. Effects of three extracts from the root of Tripterygium wilfordii on the expression of major inflammatory cytokines in inflammatory tissues and serum [J]. Chinese Journal of Traditional Chinese Medicine, 2020,35(08):4135-4139. 27. Wu Xiaohui, Wang Junming, Song Lingling, Guan Yuechen, Liu Chen, Cao can. Anti-inflammatory synergism and attenuation effect of Tripterygium wilfordii combined with Lysimachia christinae Hance before and after rheumatic heat stress [J]. Chinese Journal of Traditional Chinese Medicine, 2021,36(02):1006-1011. 28. Qu Shuai, Yan Hong, Li Jinhua, Ding Ru, Zhao Li Ru. Study on anti-inflammatory effect of gancao Fuzi decoction based on rat pleurisy model [J]. Journal of Changchun University of Traditional Chinese Medicine, 2021,37(01):67-70. 29. Wu Xiaohui, Wang Junming, Song Lingling, Guan Yuechen, Zhang Yuemei, Cui Ying. Experimental study on enhancing anti-inflammatory, analgesic and expectorant effects of Dioscorea bulbifera L. By processing [J]. Shi Zhen, National Medicine, 2020,31(11):2649-2652. 30. Yan, Wen-xia, et al. "Anti-inflammatory activity studies on the stems and roots of Jasminum lanceolarium Roxb." Journal of ethnopharmacology 171 (2015): 335-341.https://doi.org/10.1016/j.jep.2015.05.044 31. [IF=4.36] Wen-xia Yan et al."Anti-inflammatory activity studies on the stems and roots of Jasminum lanceolarium Roxb."J Ethnopharmacol. 2015 Aug;171:335 32. [IF=4.36] Qiyuan Shan et al."Change in the active component of processed Tetradium ruticarpum extracts leads to improvement in efficacy and toxicity attenuation."J Ethnopharmacol. 2021 Jan;264:113292 33. [IF=2.614] Honggang Tang et al."Effect of κ‐carrageenan addition on protein structure and gel properties of salted duck egg white."J Sci Food Agr. 2021 Mar;101(4):1389-1395 34. [IF=5.354] Anlei Ge et al.Alteration in rheology and microstructure of O/W emulsions using controlled soy protein isolate-polysaccharide aggregation in aqueous phases.J Food Eng. 2022 Mar;317:110872 35. [IF=3.171] Xiangzhao Hu et al."Layered bismuth oxide/bismuth sulfide supported on carrageenan derived carbon for efficient carbon dioxide electroreduction to formate."Chinese J Chem Eng. 2022 Feb;: 36. [IF=9.147] Liang Zhang et al."ZnO/C-mediated k-carrageenan based pseudo-pasteurization films for kumquat preservation."Food Hydrocolloid. 2022 Jul;128:107582 37. [IF=13.273] Shuang Wu et al."One-pot synthesis of anti-freezing carrageenan/polyacrylamide double-network hydrogel electrolyte for low-temperature flexible supercapacitors."Chem Eng J. 2022 May;435:135057 38. [IF=6.419] Sifan Huang et al."Modification of sodium aescinate into a safer, more stable and effective water-soluble drug by liposome-encapsulation: an in vitro and in vivo study."DRUG DELIVERY. 2022;29(1):1132-1141 |
CARRAGEENAN - Study on the model of rat foot swelling induced by carrageenan and its mechanism
from VIP Journal Professional Edition
Author:
Xiao , Zhu shaoxu , Yang Wei , Qiu Zhijian , liang hui , Magpie Yang
Abstract:
objective to investigate the model of rat foot swelling induced by carrageenan. Methods a certain number of carrageenan-induced rat foot swelling models were replicated, and the foot volume of rats at different time points after inflammation was measured and compared, and the effect of test environment temperature on the foot swelling degree of the model was investigated, the contents of inflammatory factors in rat foot tissues at different time points after inflammation were determined. Results The swelling degree of rat foot showed a single peak curve after the injection of carrageenan. The swelling began about 0.5 h after inflammation, reached the peak at 2.5~3.0 h, and gradually subsided after 8 h; ambient temperature 21 ℃ ~ 23... see all
Key words:
Model Discussion carrageenan foot swelling mechanism research
DOI:
10.3969/j.issn.1673-7555.2008.23.037
cited:
year:
2008
Last Update：2024-01-02 23:10:35
CARRAGEENAN - Mechanism of carrageenan-induced tail thrombosis in rats
from Wanfang Medical
Author:
Wei Lingbo , winter plum gemcitabine , Ding shu
Abstract:
objective to reveal the mechanism of rat tail thrombus model induced by carrageenan. Methods the rats were randomly divided into normal group, model Group and aspirin group. Model Group, aspirin group with carrageenan to build the tail thrombus model, observe the length of the black tail AT different times, check the antithrombin Ⅲ(AT-Ⅲ) activity, D-dimer, the content of interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α). The length of black tail was observed. The coagulation mechanism, tissue plasminogen activator (PAI) activity and tissue plasminogen activator inhibitor (t-PA) activity were detected. Results in model Group, IL-1β was (32.54±9.26)pg/mL, fibrinogen was (4.28±2.06)g/L, and prothrombin time was (13.12±2.40)s, which were higher than those in normal group; D-dimer content was lower than the normal group. Conclusion as long as the conditions are well controlled, carrageenan is a simple and easy animal thrombosis modeling agent.
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Key words:
carrageenan; Thrombosis; Coagulation mechanism; inflammatory factors
DOI:
10.3969/j.issn.1672-1349.2008.05.021
cited:
year:
2008
Last Update：2023-08-16 22:05:47
CARRAGEENAN - Introduction
Carrageenan is a mucopolysaccharide extracted from the cell wall of red algae. They are anionic linear polymers consisting of α-1,1,3,4 β-galactans with disaccharide units of one (κ), two (ι), or three (λ) sulfates. In ionic solution, κ-and ι-carrageenan self-crosslinks into a spiral structure, thus forming a rigid or flexible gel. λ-carrageenan does not form a spiral and is a non-gel. Carrageenan is used for commercialization as a thickener and stabilizer.
Last Update：2022-10-16 17:30:45
CARRAGEENAN - Effects of xiaochaihu decoction and its drug combination on cytokines in rat pleurisy model induced by carrageenan
from hownet
Author:
Sun Minyu , Xie Ming , Zhang Na , Eli , Wang Shouyong
Abstract:
objective to investigate the anti-inflammatory effect of xiaochaihu decoction (Bupleurum chinense, Scutellaria baicalensis, Pinellia, ginger, ginseng, licorice and jujube) and its drug combination, and to explore its possible mechanism. Methods the pleurisy model was induced by injecting 1% carrageenan 0.2ml into the thoracic cavity of rats. Each group of Chinese medicine were given xiaochaihu decoction of different drug group formula of traditional Chinese medicine (respectively according to the following composition and dosage: chaiqin 3.5g/kg, Jiang Xia 3g/kg, shencao jujube 4.5g/kg, chaiqin + Jiangxia 6.5g/kg, chaiqin + shencao jujube 8g/kg, Jiangxia + shencao jujube 7.5g/kg, the normal Group and model group were given equal volume of distilled water by gavage. Continuous administration for 5 days, 2H after the last dose, 12h after the model, pleural effusion, white blood cell count, myeloperoxidase (MPO), tumor necrosis factor-α(TNF-α), interleukin-1β (IL-1β) and serum interleukin-8 (IL-8) levels. Results compared with the model Group, the volume of pleural effusion, the number of white blood cells in exudate of rats in each group of xiaochaihu decoction and its drug group, MPO and TNF-α levels and serum IL-8 levels were significantly decreased (P<0.05). The content of IL-1β in pleural effusion of pleurisy in chaiqin group, Jiangxia group and the whole prescription group was significantly decreased (P<0.01). Conclusion xiaochaihu decoction and its combination of drugs have significant anti-inflammatory effect, and have a certain role in the prevention and treatment of pleurisy. The chaiqin group, the whole group, Jiangxia group and shencao jujube group have better effect. Its mechanism of action may be related to the inhibition of the increase of cytokines such as TNF-α,IL-1β and IL-8, and the inhibition of leukocyte activation, infiltration and migration.
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Key words:
xiaochaihu Tang drug group compatibility carrageenan cytokines Traditional Chinese Medicine pleurisy rat
DOI:
10.7661/CJIM.2004.7.628
cited:
year:
2004
Last Update：2023-08-16 22:05:47
CARRAGEENAN - Effect of volatile oil from entophylla on acute pleurisy induced by carrageenan in rats
from Wanfang Medical
Author:
Renan , Mei Xuan bud , Shi Jingli , Shen Yingjun
Abstract:
objective: to study the anti-inflammatory effect of volatile oil from entophylla and its possible mechanism. Methods: carrageenan-induced acute pleurisy in rats was used to observe the effects of high-dose (0.05mL · kg-1) and low-dose (0.1 mL · kg-1) of the volatile oil from corns urinaria on acute inflammation. Results: the volatile oil of entophylla showed obvious antagonistic effect on the increase of white blood cell count in rat pleurisy model, and could significantly reduce the production of nitric oxide (NO) and prostaglandin E2(PGE2) in the exudate of rat pleurisy, high-dose group can significantly... view all
Key words:
grass-free volatile oil Anti-inflammatory carrageenan C-reactive protein cytokines
DOI:
10.3321/j.issn:1001-5302.2005.15.016
cited:
year:
2005
Last Update：2023-08-16 22:05:47
CARRAGEENAN - Effect of liquor on thrombosis of rat tail induced by carrageenan
from hownet
Author:
, Wei Lingbo , Shi Hongxia , Li Xiao , Yin zhuhan
Abstract:
objective to observe the effect of liquor on the length of thrombus in rat tail induced by carrageenan and its effect on coagulation function and fibrinolytic function. Methods rats were randomly divided into 6 groups: Model control group, normal control group, aspirin group, liquor low, medium and high dose group, 10 rats in each group. In addition to the normal control group, the other 5 groups were used to build the model of tail thrombus with carrageenan. The length of the black tail at different times was observed, PAI,t-PA. Results after 24 and 48 hours, compared with model control group, aspirin group and low-dose liquor group, the length of black tail in high-dose liquor group was longer (P<0.05), compared with the normal control group, the PT value of liquor high dose group was significantly prolonged, P<0.01, compared with the normal control group, the PT value of liquor middle dose group was prolonged, P<0.05, compared with the model control group, the PT value of the low-dose liquor group was shortened, P<0.05; Compared with the normal control group, the FB value of the medium-dose liquor group was significantly increased, P<0.01, the rest of the group compared with the normal control group FB value increased, P<0.05; Liquor high, middle dose group compared with the normal control group PAI value increased, P<0.05. Conclusion This experiment shows that medium and large amounts of liquor can enhance the role of carrageenan-Induced Thrombosis in rats, a small amount of liquor and Oral Aspirin on carrageenan-induced rat tail thrombosis had no significant effect.
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Key words:
liquor carrageenan thrombosis coagulation function PAI t-PA
DOI:
10.3969/j.issn.1009-6639.2004.03.001
cited:
year:
2004
Last Update：2023-08-16 22:05:47
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View History
CARRAGEENAN
4-Fluoro-2-Aminotoluene
奥洛他定甲酯
Z-N-GAMMA-TRITYL-D-Asparagine
三(正丙基环戊二烯)钇(III)
(1R)-(-)-(1-AMINOPROPYL)PHOSPHONIC ACID
4-Fluoro-2-Aminotoluene
奥洛他定甲酯
Z-N-GAMMA-TRITYL-D-Asparagine
三(正丙基环戊二烯)钇(III)
(1R)-(-)-(1-AMINOPROPYL)PHOSPHONIC ACID