C-176
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
CAS: 314054-00-7
Molecular Formula: C11H7IN2O4
C-176 - Names and Identifiers
C-176 - Physico-chemical Properties
| Molecular Formula | C11H7IN2O4 |
| Molar Mass | 358.09 |
| Density | 1.935±0.06 g/cm3(Predicted) |
| Boling Point | 361.2±37.0 °C(Predicted) |
| Solubility | DMSO : 150 mg/mL (418.89 mM; Need ultrasonic) |
| Appearance | solid |
| Color | Brown or yellow |
| pKa | 11.14±0.70(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| In vitro study | C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6. |
| In vivo study | C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity. C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1 −/− mice. C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1 −/− mice. Animal Model: WT type mice. Dosage: 750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL). Administration: Intraperitoneally, once. Result: Significantly reduced Serum levels of type I IFNs and IL-6. |
C-176 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.793 ml | 13.963 ml | 27.926 ml |
| 5 mM | 0.559 ml | 2.793 ml | 5.585 ml |
| 10 mM | 0.279 ml | 1.396 ml | 2.793 ml |
| 5 mM | 0.056 ml | 0.279 ml | 0.559 ml |
Last Update：2024-01-02 23:10:35
C-176 - Reference Information
| biological activity | STING inhibitor C- 176 is an effective STING inhibitor. STING is the main signaling molecule of DNA sensing pathway in cells. |
| target | TargetValue STING () |
| Target | Value |
| in vitro study | C- 176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C- 176 markedly reduce the CMA-mediated induction of series levels of type I IFNs and IL-6. |
| in vivo study | C- 176 (750/375 nmol C- 176 per mouse in 200 μ L corn oil) significantly reduces the CMA-mediated induction of series levels of type I IFNs and IL-6, without significant toxicity. C- 176 results in a significant reduction in series levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1/MICE. C- 176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1/MICE. Animal Model: WT Type MICE. Dosage: 750/375 nmol C- 176 per mouse in 200 μ L corn oil (~ 1.34/0.67 mg/mL). Administration: Intraperitoneally, once. Result: significantly reduced Serum levels of type I IFNs and IL-6. |
| Animal Model: | WT type mice. |
| Dosage: | 750/375 nmol C- 176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL). |
| Administration: | Intraperitoneally, once. |
| Result: | Significantly reduced Serum levels of type I IFNs and IL-6. |
Last Update：2024-04-09 21:54:55
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Product Name: N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide Visit Supplier Webpage Request for quotationCAS: 314054-00-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Featured ProductsSpot supply
Product Name: C-176 Visit Supplier Webpage Request for quotationCAS: 314054-00-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Multiple SpecificationsSpot supply
Product Name: N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide Request for quotationCAS: 314054-00-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide Visit Supplier Webpage Request for quotationCAS: 314054-00-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Visit Supplier Webpage Request for quotationCAS: 314054-00-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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