Bosentan
BOSENTAN
CAS: 147536-97-8
Molecular Formula: C27H29N5O6S
Bosentan - Names and Identifiers
| Name | BOSENTAN |
| Synonyms | BOSENTAN ro47-0203 Bosentan impurity bosentan , CID 104865 2'-bipyrimidin)-4-yl)-enoxy)( Bosentan (Benzenesulfonamide) benzenesulfonamide,4-(1,1-dimethylethyl)-n-(6-(2-hydroxyethoxy)-5-(2-methoxyph 4-(tert-Butyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulf 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide n-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide |
| CAS | 147536-97-8 |
| EINECS | 643-099-1 |
| InChI | InChI=1/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32) |
Bosentan - Physico-chemical Properties
| Molecular Formula | C27H29N5O6S |
| Molar Mass | 551.61 |
| Density | 1.325±0.06 g/cm3(Predicted) |
| Melting Point | 107-110°C |
| Boling Point | 742.3±70.0 °C(Predicted) |
| Flash Point | 402.754°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | White to Pale Yeloow |
| pKa | 4.01±0.10(Predicted) |
| Storage Condition | -20°C Freezer |
| Refractive Index | 1.607 |
| Use | Endothelin receptor blocker |
Bosentan - Risk and Safety
| HS Code | 29350090 |
Bosentan - Nature
Open Data Verified Data
crystallized from acetic acid ethanol, melting point> 250 °c.
Last Update：2024-01-02 23:10:35
Bosentan - Preparation Method
Open Data Verified Data
diethyl 2- (2-methoxyphenoxy) malonate and pyridine-2-carboxamidine hydrochloride were added to a solution of sodium metal in anhydrous methanol and stirred at room temperature, the treatment gave 5-(2-methoxyphenoxy) -2- (pyridin-2-yl) pyridine-4, 6-= alcohol. The diol and N,N-= isopropyl-N-ethyl amine and phosphorus pentachloride were refluxed together, and the product was extracted with acetic acid ethanol and treated to give 4,6-= chloro-5-(2-methoxyphenoxy)-2-(pyridin-2-yl) pyridine. The compound was dissolved in dimethyl sulfoxide, P-tert-butylbenzenesulfonamide was added, and the reaction was worked up to obtain 4-tert-butyl-N-[6-monochloro-5-(2-methoxyphenoxy) -2-(pyridin-2-yl) pyridin-4-yl] benzenesulfonamide. The benzenesulfonamide was coheated with sodium and ethylene glycol at 110 °c, extracted with ethyl acetate, washed, dried, and concentrated under reduced pressure to give bosentan.
Last Update：2025-06-10 22:55:16
Bosentan - Application
Open Data Verified Data
developed by Actelion, Switzerland, was first launched in the United States in 2001. Endothelin receptor antagonists. For the treatment of pulmonary hypertension.
Last Update：2025-08-19 16:24:40
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