Boc-D-glutamicacid1-tert-butylester
Boc-D-Glu-OtBu
CAS: 73872-71-6
Molecular Formula: C14H25NO6
Boc-D-glutamicacid1-tert-butylester - Names and Identifiers
Boc-D-glutamicacid1-tert-butylester - Physico-chemical Properties
| Molecular Formula | C14H25NO6 |
| Molar Mass | 303.35 |
| Density | 1.121 |
| Boling Point | 449.8±40.0 °C(Predicted) |
| Appearance | Powder |
| Color | White to pale brown |
| pKa | 4.48±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
Boc-D-glutamicacid1-tert-butylester - Introduction
N-tert-Butoxycarbonyl-D-glutamic acid 1-tert-butyl ester (Boc-D-Glu-OtBu) is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
N-tert-Butoxycarbonyl-D-glutamic acid 1-tert-butyl ester is a solid and odorless at room temperature. It has low solubility and is soluble in organic solvents such as dimethylformamide (DMF) or dichloromethane.
Use:
N-tert-Butoxycarbonyl-D-glutamic acid 1-tert-butyl ester is commonly used as a protecting group in organic synthesis. The carboxyl group on the D-glutamic acid residue of this compound is condensed with a tert-butoxycarbonyl group (Boc group) to protect its reactivity. Boc-D-Glu-OtBu can be used as precursor molecules of synthetic peptides or proteins, which are used to synthesize polypeptides and proteins in drug or biological research.
Preparation Method:
The preparation of Boc-D-Glu-OtBu is usually obtained by reacting 1-tert-butanol having a D-glutamic acid residue with N-tert-butoxycarbonyl-N'-carbonyldi-tert-butylurea (Boc-NH-Dpnp). The reaction is generally carried out in an organic solvent and is catalyzed by the addition of a base.
Safety Information:
N-tert-Butoxycarbonyl-D-glutamic acid 1-tert-butyl ester is a chemical that should be handled and stored properly. When in use, wear appropriate personal protective equipment such as laboratory gloves and safety glasses. Avoid contact with skin and eyes. If exposed or inhaled, flush with water and seek medical advice. When stored, it should be kept in a cool, dry place, and away from fire and oxidizing agents. Detailed safety information can be found in the safety data sheets of the relevant chemical materials.
Nature:
N-tert-Butoxycarbonyl-D-glutamic acid 1-tert-butyl ester is a solid and odorless at room temperature. It has low solubility and is soluble in organic solvents such as dimethylformamide (DMF) or dichloromethane.
Use:
N-tert-Butoxycarbonyl-D-glutamic acid 1-tert-butyl ester is commonly used as a protecting group in organic synthesis. The carboxyl group on the D-glutamic acid residue of this compound is condensed with a tert-butoxycarbonyl group (Boc group) to protect its reactivity. Boc-D-Glu-OtBu can be used as precursor molecules of synthetic peptides or proteins, which are used to synthesize polypeptides and proteins in drug or biological research.
Preparation Method:
The preparation of Boc-D-Glu-OtBu is usually obtained by reacting 1-tert-butanol having a D-glutamic acid residue with N-tert-butoxycarbonyl-N'-carbonyldi-tert-butylurea (Boc-NH-Dpnp). The reaction is generally carried out in an organic solvent and is catalyzed by the addition of a base.
Safety Information:
N-tert-Butoxycarbonyl-D-glutamic acid 1-tert-butyl ester is a chemical that should be handled and stored properly. When in use, wear appropriate personal protective equipment such as laboratory gloves and safety glasses. Avoid contact with skin and eyes. If exposed or inhaled, flush with water and seek medical advice. When stored, it should be kept in a cool, dry place, and away from fire and oxidizing agents. Detailed safety information can be found in the safety data sheets of the relevant chemical materials.
Last Update：2024-04-09 15:17:59
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View History
Boc-D-glutamicacid1-tert-butylester
acidbrilliantgreenbs
4-cinnamamidobenzoic acid
(E)-but-2-enedioate
6-Amino-o-cresol
三(4-壬苯基)亚磷酸酯
1-Isopropenyl-4-methoxybenzene
4-甲基-3-硝基苯甲酰氯
2-甲基-6-丙烷-2-苯酚
acidbrilliantgreenbs
4-cinnamamidobenzoic acid
(E)-but-2-enedioate
6-Amino-o-cresol
三(4-壬苯基)亚磷酸酯
1-Isopropenyl-4-methoxybenzene
4-甲基-3-硝基苯甲酰氯
2-甲基-6-丙烷-2-苯酚