BIOTINUM
Vitamin B6
CAS: 8059-24-3
Molecular Formula: C10H16N2O3S
BIOTINUM - Names and Identifiers
| Name | Vitamin B6 |
| Synonyms | BIOTIN BIOS H BIOTINUM Vitamin B6 BIOEPIDERM (+)-BIOTIN BIOTIN(V-H) BIOTIN, IMMOBILIZED ON DEXTRAN BIOTIN, IMMOBILIZED ON DEXTRAN-LYSINE |
| CAS | 8059-24-3 |
| EINECS | 232-503-8 |
BIOTINUM - Physico-chemical Properties
| Molecular Formula | C10H16N2O3S |
| Molar Mass | 244.31 |
| Melting Point | 231-233°C(lit.) |
| Solubility | H2O: 0.2mg/mL Solubility increases with addition of 1N NaOH. |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | The chemical properties are more stable and more stable in acidic solutions. If it is subjected to light or oxidant under neutral and alkaline conditions, it will lose its activity. Solubility: Soluble in water and ethanol, insoluble in ether and other organic solvents. Form: colorless crystal. Figure 2 is the chemical structural formula of vitamin B6 and its derivatives. |
BIOTINUM - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | XJ9088200 |
| FLUKA BRAND F CODES | 8 |
BIOTINUM - References
| introduction | vitamin B6 is also called "anti-dermatitis vitamin". One of the B vitamins. It is a pyridine derivative, including pyridoxine (pyridoxine), pyridoxal (pyridoxal), and pyridoxamine (pyridoxamine). They exist in the form of mutual conversion in food. But vitamin B6 in plants is mostly pyridoxine, while pyridoxal and pyridoxamine are mostly in humans and animals. Human intestinal bacteria can also synthesize pyridoxine. In the human body, pyridoxine can be converted into pyridoxal and pyridoxamine, and the latter two cannot be converted into pyridoxine. The three have the same physiological activity. Vitamin B6 is rapidly transformed into pyridoxal phosphate in the human body. This compound plays an important role in amino acid metabolism. It is a coenzyme for decarboxylase, transaminase, canine uricase, deaminase, and desulphurization hydration enzyme. It is also a coenzyme necessary for carbohydrate and fat metabolism, central nervous system activities, and red egg production. vitamin B6 widely exists in nature, egg yolk, fish, meat, seed, cereal (germ) content is more, the general diet does not lack of this vitamin. Vitamin B6, can cause dermatitis, spasm, anemia and other symptoms. Vitamin B6 is mainly used for vomiting caused by pregnancy, radiation sickness and anti-cancer drugs, vitamin B6 deficiency, seborrheic dermatitis, cheilitis, angular cheilitis and acute and chronic eczema, etc. It can also be used in food fortifiers, feed additives and cosmetics. fig. 1 is a demonstration diagram of the transformation of pyridoxine (pyridoxine), pyridoxal (pyridoxal) and pyridoxamine (pyridoxamine) in human body. |
| Source | Vitamin B6 includes pyridoxine (pyridoxine, Pyridoxine), pyridoxine (Pyridoxal) and pyridoxine (Pyridoxamine), the three can be transformed into each other, and all have the effect of vitamin B6. The above three forms are present in egg yolks, meat, fish, milk, grains, seed rind, beans, cabbage and other vegetables at low concentrations. Human intestinal bacteria can also synthesize vitamin B6, which is more abundant in yeast, liver, grain, meat, fish, eggs, beans and peanuts. |
| Pharmacological effects | In the body, it can produce active pyridoxal and pyridoxine phosphate by enzymatic interaction with ATP. The latter acts as a coenzyme for proteins, carbohydrates, and lipids. Various metabolic functions play a role. Vitamin B6 is also involved in the conversion of tryptophan to niacin or serotonin. It is mainly absorbed by the jejunum in the gastrointestinal tract, and pyridoxamine phosphate is completely bound to plasma protein. T1/2 lasts for 15-20 days. It is metabolized by the liver, excreted by the kidney, and can also be excreted through hemodialysis. The first step in heme synthesis is that glycine is linked to pyridoxal phosphate converted by vitamin B6, and then combined with succinic acid-coenzyme A under the action of δ-aminopropionyl acetate synthetase to form δ-amino-γ-ketopentanoic acid (ALA). After a series of enzymes, protoporphyrin is finally formed in the mitochondria. Iron enters the porphyrin ring and combines with the protoporphyrin to form heme. Reduce the stimulation of emetic chemoreceptors, reduce nausea, vomiting and other symptoms, and promote the growth of white blood cells. Topical application can improve local nerve function and reduce inflammatory response. |
| physiological function | vitamin B6 is a coenzyme of transaminase and amino acid decarboxylase, which promotes the absorption of amino acids and protein synthesis and is necessary for cell growth. Involved in a variety of metabolism in the body. |
| Vitamin B6 deficiency | Vitamin B6 deficiency includes narrow vitamin B6 deficiency and vitamin B6 dependence. In the narrow sense, vitamin B6 deficiency refers to the deficiency of vitamin B6 from food or taking certain drugs, which makes vitamin B6 inactive and thus occurs. Vitamin B6 dependence refers to the amount of vitamin B6 needed by healthy people, but vitamin B6 deficiency still occurs, mostly hereditary diseases. Normal diet, vitamin B6 deficiency rarely occurs. At present, the vitamin B6 deficiency seen in clinical practice is mostly caused by taking vitamin B6 antagonists such as isoniazid, cycloserine, penicillamine, etc.; a few are due to malignant tumors, severe liver and kidney diseases, Chronic alcoholism; infants who are improperly fed and elderly people with loss of appetite can also get sick. Main clinical manifestations: skin and mucous membrane inflammation, common seborrheic and desquamative dermatitis, stomatitis, glossitis, ophthalmia, etc. The second is mental and nervous system symptoms, such as nervousness, depression, drowsiness, nausea, vibration and position, peripheral neuritis, etc. Vitamin B6 deficiency causes heme synthesis and folic acid metabolism to be blocked and causes anemia. It is a hypochromic small cell anemia, but it is not a lack of iron, but an insufficient use of iron. Excess iron is deposited in the liver in the form of ferritin, Spleen, bone marrow, liver and splenomegaly may occur clinically. In addition, vitamin B6 deficiency in infants and young children can still have growth retardation, weight loss, weight loss and other growth and development abnormalities. The diagnosis of vitamin B6 deficiency in a narrow sense: it can only be established based on medical history, symptoms, signs and necessary experimental examinations. Determination of urine yellow uric acid excretion after oral administration of tryptophan 100 mg/kg can measure the nutritional status of vitamin B6 in the body. If the excretion in 6 hours and 24 hours is higher than 25mg and 75mg respectively, it is considered that the body is deficient in vitamin B6. The most effective way to treat vitamin B6 deficiency: supplement a large amount of vitamin B6. Patients taking large amounts of isoniazid or penicillamine should also take appropriate amounts of vitamin B6 to prevent peripheral neuritis caused by isoniazid and optic neuritis caused by penicillamine. Patients with tuberculosis who have a history of seizures should be given vitamin B6 routinely when taking isoniazid to prevent seizures. |
| Indications | (1) Suitable for vitamin B6 deficiency (vitamin B6 deficiency can cause xanthine aciduria, sideroblastic anemia, neurological diseases, seborrheic dermatitis and chapped lips) treatment, treatment of isoniazid poisoning; it can also be used for pregnancy, radiation sickness and anti-cancer drugs caused vomiting, seborrheic dermatitis, etc. (2) Total parenteral nutrition and vitamin B6 supplementation during malnutrition and progressive weight loss due to insufficient intake. (3) Treat infantile convulsions or take them to pregnant women to prevent infantile convulsions. (4) Leukopenia. |
| efficacy | invigorating spleen and qi, nourishing heart and tranquilizing mind. 1. Used for lung-spleen deficiency syndrome. This product can invigorate the spleen and replenish qi. It is a common medicine for the treatment of loss of appetite, fatigue, weakness, dizziness, nausea and vomiting, muscle weakness, skin numbness and other lung-spleen deficiency syndromes. 2. used for palpitations and insomnia. This product can nourish the heart and soothe the nerves, and is often used to treat heart palpitations caused by weak qi and blood, heart loss, insomnia, numbness of hands and feet, etc. This information is edited by Shi Yan. |
| adverse reactions | vitamin B6 is hardly toxic to patients with normal renal function. If you take 200mg daily for more than 30 days, it has been reported that vitamin B6 dependence syndrome can occur. Taking 20~60g a day for several months can cause severe neurosensory abnormalities, progressive gait instability to numbness of feet, inflexible hands, and can be relieved after stopping the drug. Allergic reactions such as rash and anaphylactic shock are occasionally seen. Occasionally, skin irritation such as burning sensation, or allergic reactions such as rash, itching, etc. |
| content determination | for the determination of vitamin B6 content in food and pharmaceutical preparations, common methods include microbial analysis, ultraviolet spectrophotometry, flow injection spectrophotometry and high performance liquid chromatography. Microbial method is a common analysis method of vitamin B6 in food. Its principle is that vitamin B6 is a vitamin necessary for the normal growth of Carlsberg yeast. Under certain conditions, the growth and reproduction speed of yeast is proportional to the content of vitamin B6 in the solution. The sensitivity of this method is higher than that of other instrumental and chemical methods, so it cannot be replaced by other methods when determining the vitamin B6 content in some foods. However, due to the complicated sample processing method and long experimental period, further improvement is necessary. High performance liquid chromatography (HPLC) is fast, sensitive and accurate, requires few samples, and can be combined with other analytical techniques. Therefore, in recent years, it has been widely used in the determination of vitamin B6 in pharmaceutical preparations at home and abroad. |
| precautions | (1) chloramphenicol, cycloserine, isonicotinine, hydrazine nicotinic acid, immunosuppressants including adrenal cortex hormones, cyclophosphamide, cyclosporine, isoniazid, penicillamine and other drugs can antagonize vitamin B6 or increase the renal excretion of vitamin B6, causing anemia or peripheral neuritis. (2) when taking estrogen, the dosage of vitamin B6 should be increased. (3) When combined with levodopa, it will reduce its efficacy. (4) It is forbidden for people who are allergic to this product. (5) Pregnant women receive a large amount of vitamin B6, which can cause vitamin B6 dependence syndrome in newborns. The normal intake of lactating women has no adverse effect on infants. (6) This product can make the urobilinogen test false positive. |
Last Update：2024-04-09 20:52:54
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View History
BIOTINUM
34760-60-6
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n-Butyl phenylacetate
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52565-83-0
heptan-3-
6418-57-1
三硫二丙烯
34760-60-6
Diethyl acetylsuccinate
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n-Butyl phenylacetate
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heptan-3-
6418-57-1
三硫二丙烯