Astragaloside

Astragaloside - Names and Identifiers

Name	Astragaloside
Synonyms	ASTRAGALOSIDE Astragaloside Astragalosidemix Astragalosidemixof Total Saponins from Astragali Radix 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxymethyl]-2-oxanyl]oxy]-1-benzopyran-4-one
CAS	17429-69-5

Astragaloside - Physico-chemical Properties

Molecular Formula	C28H32O17
Molar Mass	640.54
Melting Point	222-224 °C
Boling Point	1000.6°C at 760 mmHg
Solubility	Soluble in water, methanol, insoluble in petroleum ether, and other solvents.
Appearance	White crystalline powder
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
MDL	MFCD07368617
Physical and Chemical Properties	White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Astragalus Astragalus membranaceus (Fisch.) Bunge..

Astragaloside - Reference

Reference

1. Jin huaqian, Ding Wenqian, Chu Lisheng, etc. Effects of total saponins of astragalus on proliferation of rat neural stem cells in vitro [J]. Zhejiang Journal of Traditional Chinese Medicine, 2018, 053(001):12-14.
2. Gu Jing, Li Hailong, Liu Kai, etc. Protective effect of total saponins of astragalus on cardiomyocyte hypertrophy induced by endoplasmic reticulum stress [J]. Chinese Journal of Gerontology, 2015, 35(017):4774-4776.
3. Sangzhenchi, Xu sanbin, Qian Junfeng, etc. Effects of total saponins of astragalus on cardiac function and left ventricular remodeling in rats with heart failure [J]. Journal of Integrated Traditional Chinese and Western medicine, 2017(17).
4. Chen Xiao, Wang Dongdong, Wei Tong, He Sumei, Song Yifan, Wei Qunli. Effects of total saponins of astragalus on proliferation and iNOS/NO expression of rat Glomerular mesangial cells induced by high glucose [J]. Chinese Journal of biochemical drugs, 2015, 35(01):49-51.
5. Fu Li, Zhang Liang, Yang Jing, etc. Effect of Astragalosides on the growth of keloid fibroblasts [J]. China pharmacist, 2016, 29 (9):1644-1647.
6. [IF = 1.448] Xiao Chen et al."Effects of astragalosides from Radix Astragali on high glucose‑induced proliferation and extracellular matrix accumulation in glomerular mesangial cells."Exp Ther Med. 2016 Jun;11(6):2561-2566
7. [IF=5.81] Gu Junfei et al."Standardized Astragalus Mongholicus Bunge-Curcuma Aromatica Salisb. Extract Efficiently Suppresses Colon Cancer Progression Through Gut Microbiota Modification in CT26-Bearing Mice."Front Pharmacol. 2021 Aug;0:2278
8. [IF=4.36] Yu Wang et al."Astragalus saponins improves stroke by promoting the proliferation of neural stem cells through phosphorylation of Akt."J Ethnopharmacol. 2021 Sep;277:114224
9. [IF=2.744] Zhi-Bin Jiang et al."Astragaloside alleviates alcoholic fatty liver disease by suppressing oxidative stress."Kaohsiung J Med Sci. 2021 Aug;37(8):718-729
10. [IF=2.629] Guan Mengqi et al."The Aqueous Extract of Eucommia Leaves Promotes Proliferation, Differentiation and Mineralization of Osteoblast-Like MC3T3-E1 Cells."Evid-Based Compl Alt. 2021;2021:3641317
11. [IF=2.447] Huan Guo et al."The preventive effect of Apocynum venetum polyphenols on D‑galactose‑induced oxidative stress in mice."Exp Ther Med. 2020 Jan;19(1):557-568

Astragaloside - Introduction

Astragaloside, also known as Astragaloside Astragaloside, is an important active ingredient extracted from traditional Chinese medicine Astragalus (Astragalus membranaceus). It is a triterpene compound with complex chemical structure, molecular formula C41H68O14, molecular weight of 784.98.

Astragaloside has a variety of biological activities, including immunomodulatory, antioxidant, anti-inflammatory, cardiovascular protection, anti-tumor and other effects. It can enhance the body's immune function, improve antioxidant capacity, reduce inflammation, prevent cardiovascular disease, inhibit the growth of tumor cells, and have a certain therapeutic effect on a variety of diseases.

The method of preparing Astragaloside mainly uses ultrasonic extraction, boiling extraction, enzymatic extraction, etc. Among them, the ultrasonic extraction method is generally considered to be an efficient, environmentally friendly, low-energy extraction method.

Regarding the safety of Astragaloside, generally speaking, the traditional Chinese medicine Astragaloside is widely used and is considered to be relatively safe without serious side effects. However, high dose use or long-term use of Astragaloside may cause some unpleasant reactions, such as dizziness, nausea, diarrhea, etc. For pregnant women, lactating women, children and other special populations, more research and evaluation of its safety is needed.

In General, Astragaloside has potential medicinal value, but it should follow the appropriate dosage and usage when using it, and use it under the guidance of a doctor.

Last Update：2024-04-10 22:29:15