Arctigenin
Arctigenin
CAS: 7770-78-7
Molecular Formula: C21H24O6
Arctigenin - Names and Identifiers
Arctigenin - Physico-chemical Properties
| Molecular Formula | C21H24O6 |
| Molar Mass | 372.41 |
| Density | 1.227±0.06 g/cm3(Predicted) |
| Melting Point | 98.0 to 102.0 °C |
| Boling Point | 567.0±45.0 °C(Predicted) |
| Specific Rotation(α) | -28.7°（c=1.2，chloroform） |
| Flash Point | 198.8°C |
| Solubility | DMSO : ≥ 125 mg/mL (335.65 mM) |
| Vapor Presure | 1.85E-13mmHg at 25°C |
| Appearance | Colorless flake crystal (ethyl acetate) |
| Color | White to Light yellow |
| Maximum wavelength(λmax) | ['280nm(EtOH)(lit.)'] |
| pKa | 10.03±0.20(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.576 |
| MDL | MFCD00870597 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from fructus arctii, collostii, King of the GE, Saussurea medusa, forsythia. |
Arctigenin - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | LY9247000 |
Arctigenin - Reference
| Reference Show more | 1. Jia-Xin Xu, Jia-ji, Rui Yang, Yu-Chen Li, Si-yuan, Liu Ying. Molecular docking and molecular dynamics study of natural medicine arctigenin directly targeting STAT3 to inhibit triple negative breast cancer [J]. Journal of Hubei University of Medicine, 2019,38(01):1-9. 2. Di Hengjian, Li Song, Guo Qing, etc. Study on HPLC fingerprint of fructus arctii formula granules [J]. Pharmaceutical and Clinical Research, 2013, 021(006):637-639. 3. Lu Ming, Ji Feihong, Zhang Linjie. Effect of arctigenin on the proliferation of mouse spleen cells and related mechanism [J]. Journal of Anhui Medical University, 2014, 26 (6):726-730. 4. Yuan Xiaoning, Ma Wenjing, Sun Zhiting, etc. Effect and mechanism of arctigenin on inhibiting metastasis of triple negative breast cancer by down-regulating CIP2A [J]. Journal of Hubei University of Medicine, 2017(05):391-396. 5. Yur Du, Wenjing Li, Yiming Li, Juxiang Yang, Xinhao Wang, Shuo Yin, Xi Wang, mar Israel velezde-la-Paz, Yuan Gao, Haiying Chen, Xi Yin, Haishui Shi, Repeated arctigenin treatment produces antidepressant- and anxiolytic-like effects in mice, Brain Resear 6. Huang, Qiuyue, et al. "Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A." Oncology reports 38.1 (2017): 598-606.https://doi.org/10.3892/or.2017.5667 7. Feng, Tingting, et al. "Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy." Oncotarget 8.1 (2017): 329.https://dx.doi.org/10.18632/oncotarget.13393 8. Lu, Yu-Nan, et al. "Arctigenin exhibits hepatoprotective activity in Toxoplasma gondii-infected host through HMGB1/TLR4/NF-κB pathway." International immunopharmacology 84 (2020): 106539.https://doi.org/10.1016/j.intimp.2020.106539 9. Cheng, Jia-Hui, et al." Arctigenin ameliorates depression-like behaviors in Toxoplasma gondii-infected intermediate hosts via the TLR4/NF-κB and TNFR1/NF-κB signaling pathways." International immunopharmacology 82 (2020): 106302.https://doi.org/10.1016/j. I 10. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 11. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 12. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 13. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884 14. [IF=4.077] Yuru Du et al."Repeated arctigenin treatment produces antidepressant- and anxiolytic-like effects in mice."Brain Res Bull. 2019 Mar;146:79 15. [IF=3.417] Qiuyue Huang et al."Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A."Oncol Rep. 2017 Jul;38(1):598-606 16. [IF=0] Tingting Feng et al."Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy."Oncotarget. 2017 Jan 3; 8(1): 329-344 17. [IF=3.943] Jia-Hui Cheng et al."Arctigenin ameliorates depression-like behaviors in Toxoplasma gondii-infected intermediate hosts via the TLR4/NF-κB and TNFR1/NF-κB signaling pathways."Int Immunopharmacol. 2020 May;82:106302 18. [IF=3.943] Yu-Nan Lu et al."Arctigenin exhibits hepatoprotective activity in Toxoplasma gondii-infected host through HMGB1/TLR4/NF-κB pathway."Int Immunopharmacol. 2020 Jul;84:106539 19. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 20. [IF=2.447] Wenfang Luo et al."Arctigenin inhibits human breast cancer cell proliferation, migratory and invasive abilities and epithelial to mesenchymal transition by targeting 4EBP1."Exp Ther Med. 2021 Jun;21(6):1-7 21. [IF=5.81] Zhu DW et al."Exploring the Anti-Pulmonary Fibrosis Mechanism of Jingyin Granule by Network Pharmacology Strategy.."Front Pharmacol. 2022 Feb;13:825667-825667 |
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