Aqoat
acetic acid, methanol, propane-1,2-diol, succinic acid
CAS: 71138-97-1
Molecular Formula: C10H22O9
Aqoat - Names and Identifiers
| Name | acetic acid, methanol, propane-1,2-diol, succinic acid |
| Synonyms | Aqoat HyproMellose Acetate Succinate Hypromellose Acetate Succinate (100 mg) HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE Hydroxypropyl Methyl cellulose acetate succinate JPE acetic acid, methanol, propane-1,2-diol, succinic acid Cellulose,2-hydroxypropylmethylehter,acetatehydrogenbutanedioate |
| CAS | 71138-97-1 |
| InChI | InChI=1/C4H6O4.C3H8O2.C2H4O2.CH4O/c5-3(6)1-2-4(7)8;1-3(5)2-4;1-2(3)4;1-2/h1-2H2,(H,5,6)(H,7,8);3-5H,2H2,1H3;1H3,(H,3,4);2H,1H3 |
Aqoat - Physico-chemical Properties
| Molecular Formula | C10H22O9 |
| Molar Mass | 286.276 |
| Melting Point | >203°C (dec.) |
| Boling Point | 236.1°C at 760 mmHg |
| Flash Point | 110.9°C |
| Solubility | Practically insoluble in ethanol (95%), hexane, unbufferedwater, and xylene. On the addition of acetone, or a mixtureof ethanol (95%) and dichloromethane (1 : 1), a clear or turbidviscous solution is produced. Hypromellose acetate succinatealso forms a clear or turbid solution in buffers of pH greater than4.5 with the rank order of solubility for the various grades increasing with the ratio of acetyl over succinoylsubstitution. The exact pH value at which the polymer starts toswell and dissolve |
| Vapor Presure | 0.0165mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
Aqoat - Risk and Safety
| HS Code | 3912390000 |
Aqoat - Standard
Authoritative Data Verified Data
This product is Hypromellose of acetic acid, succinic acid mixed ester. According to the calculation of the dried product, the methoxy group is 12.0% to 28.0%, the 2-hydroxypropoxy group is 4.0% to 23.0%, the acetyl group is 2.0% to 16.0%, and the succinyl group is 4.0% to 28.0%.
Last Update：2024-01-02 23:10:35
Aqoat - Trait
Authoritative Data Verified Data
- This product is white or light yellow powder or granules, odorless and tasteless.
- This product is insoluble in ethanol and water, dissolved in methanol and acetone, and swelled into a clear or slightly turbid colloidal solution in cold water.
viscosity
take 2.00g of this product (pre-dried), add sodium hydroxide solution to make 100g, shake for 30 minutes. The viscosity is measured at 20°C ± 0.1°C according to the law (General rule 0633 second method) and is 80%-120% of the indicated value.
Last Update：2022-01-01 11:28:35
Aqoat - Exam
Authoritative Data Verified Data
acetic acid, succinic acid
take 0.102g of this product, precision weighing, Erlenmeyer flask, precision plus human phosphate solution (take 0.02mol/L potassium dihydrogen phosphate solution, adjust pH value to 7.5 with lmol/L sodium hydroxide solution) 4.0ml, stir for 2 hours, add 1.25 ml of phosphoric acid solution (take 4.0 mol/L phosphoric acid lm l, put it in a 50ml measuring flask, dilute it to the mark, shake it well), shake it strongly, centrifuge, and the supernatant is used as the test solution; Take 0.13g of succinic acid accurately, put it in a 100ml measuring flask, add appropriate amount of water, shake to completely dissolve, add water to the scale, shake well, as
It is a stock solution of succinic acid; Take a 100ml measuring flask with 20ml of water, weigh it, add 2ml of glacial acetic acid with precision, weigh it again, dilute it with water to the scale, shake it well, take 6ml with precision, prepare 4.0ml of acetic acid stock solution and ml of succinic acid stock solution, and place them in the same 25ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. Test according to high performance liquid chromatography (General 0512). The mobile phase was 0.02mol/L potassium dihydrogen phosphate solution (adjusted to pH 2.8 with 6moI/L phosphoric acid solution) with a flow rate of 1 ml per minute and a detection wavelength of 215nm. Take 10M1 of the control solution and inject it into human liquid chromatograph. Calculate according to the succinic acid peak, the number of theoretical plates shall not be less than 8000.
loss on drying
take this product and dry it at 105°C for 1 hour, and the weight loss shall not exceed 5.0% (General rule 0831).
ignition residue
lg of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed 0.2%.
Heavy metals
The residue left under the item of burning and flooding shall be inspected according to law (General rule 0821) and shall not contain more than 10 parts per million of heavy metals.
arsenic salt
take this product l.Og, add calcium hydroxide l.Og, mix, add water and stir evenly, after drying, first burn with small fire to charring, then burn at 500~600°C to completely Ash, cool, add hydrochloric acid 5ml and water 23ml, inspection according to law (General Principles 0822 first law), shall comply with the provisions (0.0002%).
Last Update：2022-01-01 11:28:36
Aqoat - Content determination
Authoritative Data Verified Data
acetyl and succinyl groups were measured by high performance liquid chromatography (General 0512).
Chromatographic conditions and system adaptability test with acetic acid, succinic acid under
- determination method: take 12.4mg of this product, weigh it accurately, put it in an Erlenmeyer flask, and add it accurately. Omol/L sodium hydroxide solution 4.Oml, stirred for 4 hours, add 1.25mol/1 Phosphoric acid solution 4.0ml to make the pH value is 3 or slightly less, strong shaking, filtering with filter membrane (0.22um), the filtrate was used as a test solution; A control solution under the items of acetic acid and succinic acid was used as a control solution.
- methoxy and 2-hydroxypropoxy methoxy take this product, determination according to law (General 0712), if using the second method (Volumetric method), take this product, precision weighing, the measured methoxyl amount (%) was obtained by subtracting the product of the hydroxypropoxyl amount (%) and (31/75 × 0.93).
- 2-hydroxypropoxy group take this product, according to the determination (General 0712), that is obtained.
Last Update：2022-01-01 11:28:37
Aqoat - Category
Authoritative Data Verified Data
pharmaceutical excipients, coating materials.
Last Update：2022-01-01 11:28:37
Aqoat - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:28:37
Supplier List
Multiple Specifications
Product Name: HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE Request for quotationCAS: 71138-97-1
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Product Name: Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) Visit Supplier Webpage Request for quotationCAS: 71138-97-1
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Product Name: Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) Visit Supplier Webpage Request for quotationCAS: 71138-97-1
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Product Name: Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) Visit Supplier Webpage Request for quotationCAS: 71138-97-1
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Product Name: acetic acid, methanol, propane-1,2-diol, succinic acid Request for quotation
CAS: 71138-97-1
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Multiple Specifications
Product Name: HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE Request for quotationCAS: 71138-97-1
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Spot supply
Product Name: Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) Visit Supplier Webpage Request for quotationCAS: 71138-97-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) Visit Supplier Webpage Request for quotationCAS: 71138-97-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) Visit Supplier Webpage Request for quotationCAS: 71138-97-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: HPMCAS Visit Supplier Webpage Request for quotationCAS: 71138-97-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: acetic acid, methanol, propane-1,2-diol, succinic acid Request for quotation
CAS: 71138-97-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 71138-97-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
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Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
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