Apigenin
apigenin
CAS: 520-36-5
Molecular Formula: C15H10O5
Apigenin - Names and Identifiers
| Name | apigenin |
| Synonyms | 75590 75580 apigenin Versuline Pelargidenon 1449 APIGENIN CRYSTALLINE APIGENIN FROM PARSLEY C.I. Natural Yellow 1 4',5,7-trihydroxyflavaone Matricaria chamomilla flower 4,5,7-Trihydroxyflavone (apigenin) 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one |
| CAS | 520-36-5 |
| EINECS | 208-292-3 |
| InChI | InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H |
| InChIKey | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
Apigenin - Physico-chemical Properties
| Molecular Formula | C15H10O5 |
| Molar Mass | 270.24 |
| Density | 1.2319 (rough estimate) |
| Melting Point | >300 °C (lit.) |
| Boling Point | 333.35°C (rough estimate) |
| Flash Point | 217°C |
| Solubility | Almost insoluble in water, partially soluble in hot ethanol, soluble in dilute KOH solution. |
| Vapor Presure | 6E-13mmHg at 25°C |
| Appearance | Yellow powder |
| Color | yellow |
| Merck | 14,730 |
| BRN | 262620 |
| pKa | 6.53±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Sensitive | Sensitive to light |
| Refractive Index | 1.6000 (estimate) |
| MDL | MFCD00006831 |
| Physical and Chemical Properties | Melting point 345-350°C |
Apigenin - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | LK9276000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29329985 |
Apigenin - Reference Information
| introduction | apigenin is a bioflavonoid compound that can be found in various plants and herbs. Chamomile tea is very rich in content and plays a role in reducing anxiety when taken in high doses. At higher doses, it can be a sedative. |
| Plant source | Apigenin (Apigenin) is a naturally occurring flavonoid compound, which exists in a variety of plants in the form of phytoyellow pigment, mainly derived from Umbelliferae. It is also found in other plants such as chamomile, bee flower, perilla, verbena, and yarrow. Chamomile is native to England and planted in Germany, France and Morocco. Roman chamomile and German chamomile have many common characteristics: about 30cm tall, yellow in the center, white flowers, slightly furry leaves. Chamomile has the effect of helping sleep, relieving the patient's inflammation and pain symptoms, and relieving insomnia caused by neurotic skin itching. China also has a large number of cultivation, used as medicine and tea. The ingredients of herbal tea sold on a daily basis contain apigenin, mainly from the dried mother chrysanthemum chamomile. |
| Biological activity and pharmacological effects | The molecular structure of apigenin determines its unique physiological effects and biological characteristics, and has good biological effects. A large number of domestic and foreign studies have found that Apigenin is a natural antioxidant, which has the effects of lowering blood pressure and relaxing blood vessels, preventing atherosclerosis, and inhibiting tumors. Compared with other flavonoids (quercetin, kaempferia flavone), it has the characteristics of low toxicity and no mutagenicity. At present, apigenin has certain applications in medicine, food and other industries. However, due to its poor water solubility and low intestinal absorption, apigenin has low oral bioavailability and low in vivo activity, which limits its application to a certain extent. |
| uses | flavonoids (flavonoid) can capture G2/M phase of cell cycle and inhibit cell expansion. Inhibit growth, induce apoptosis, for tumor drugs. A plant flavonoid that has been found to inhibit cell proliferation by blocking the cell cycle in the G2/M phase. Inhibition of growth by cell cycle arrest and induction of apoptosis seems to be associated with the induction of p53. Suppression of PMA-mediated tumor promotion by inhibition of protein kinase C and the resulting inhibition of oncogene expression. The study also reported the inhibition of topoisomerase I-catalyzed DNA reconnection and enhancement of gap junction cell-to-cell communication. |
| category | toxic substances |
| stimulation data | slight allergy |
| flammability hazard characteristics | thermal decomposition spicy stimulation smoke |
| storage and transportation characteristics | warehouse low temperature ventilation and drying |
| fire extinguishing agent | water, carbon dioxide, foam, dry powder |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:50
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View History
Apigenin
p-ethylpropiophenone
Starkle
SDD
Sulfur phosphide (R)
2-hydroxy-3-methoxybenzenecarbonitrile
2-METHYL-2-PROPENENITRILE
敌草索
p-ethylpropiophenone
Starkle
SDD
Sulfur phosphide (R)
2-hydroxy-3-methoxybenzenecarbonitrile
2-METHYL-2-PROPENENITRILE
敌草索