Ansamycin
Rifabutin
CAS: 72559-06-9
Molecular Formula: C46H62N4O11
Ansamycin - Names and Identifiers
| Name | Rifabutin |
| Synonyms | Rifabutin Ansamycin RIFABUTINE 72559-06-9 4-N-ISOBUTYLSPIROPIPERIDYLRIFAMYCIN S 1',4-Didehydro-1-deoxy-1,4-dihydro-5'-(2-methylpropyl)-1-oxo- 1,4-dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycinxiv 1,4-dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxo-rifamycinxi 4-deoxo-3,4-(2-spiro(n-isobutyl-4-piperidyl)-2,5-dihydro-1h-imidazo)-rifamyc |
| CAS | 72559-06-9 |
| InChI | InChI=1/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12+,20-15+,24-14-/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1 |
Ansamycin - Physico-chemical Properties
| Molecular Formula | C46H62N4O11 |
| Density | 1.339g/cm3 |
| Boling Point | 969.589°C at 760 mmHg |
| Flash Point | 540.188°C |
| Solubility | DMSO 60 mg/mL Water <1 mg/mL Ethanol 40 mg/mL |
| Vapor Presure | 0mmHg at 25°C |
| Storage Condition | Room Temprature |
| Sensitive | Sensitive to light |
| Refractive Index | 1.623 |
| Physical and Chemical Properties | magenta crystalline powder. Very soluble in chloroform, soluble in methanol, ethanol-soluble, very slightly soluble in water. UV absorption maximum (methanol):493,315,274,238nm. |
| Use | Rifamycin derivatives, the role of rifampicin resistant tuberculosis strains. The required concentration is only 1/40 of that of rifampicin. Less toxic than rifampicin. Japan uses it for the treatment of atypical tuberculosis infections. Also effective against drug-resistant leprosy. Prevention of Mycobacterium tuberculosis infection in human AIDS birds. |
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