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Ahistamin

tripelennamine hydrochloride

CAS: 154-69-8

Molecular Formula: C16H22ClN3

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Ahistamin - Names and Identifiers

Name tripelennamine hydrochloride
Synonyms Ahistamin
Tripelennamine HCl
Antiallergicum medivet
tripelennamine hydrochloride
N-benzyl-N',N'-dimethyl-N-(pyridin-2-yl)ethane-1,2-diamine
2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinhydrochloride
2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinmonohydrochloride
2-(benzyl(2-(dimethylamino)ethyl)amino)pyridinemonohydrochloride
Ethylenediamine, N-benzyl-N',N'-dimethyl-N-(2-pyridyl)-, hydrochloride
2-ethanediamine,n,n-dimethyl-n'-(phenylmethyl)-n'-2-pyridinyl-monohydroc
1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, monohydrochloride
CAS 154-69-8
EINECS 205-833-5
InChI InChI=1/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H

Ahistamin - Physico-chemical Properties

Molecular FormulaC16H22ClN3
Molar Mass291.82
Density1.20
Melting Point192-193℃
Boling Point387.8°C at 760 mmHg
Flash Point188.3°C
Solubility Soluble in methanol, water
Vapor Presure3.21E-06mmHg at 25°C
AppearanceWhite solid
Storage ConditionKeep in dark place,Inert atmosphere,Room temperature
MDLMFCD00012815
In vitro studyTripelennamine is a substrate of a tertiary amine UDP glucuronosyltransferase enzyme that catalyzes the formation of quaternary ammonium-linked glucoglycinate. In human and rabbit liver microsomes, Tripelennamine can inhibit [4,5-b] pyrimidine (PhIP) glycolipidation, inhibition of both competitive and non-competitive inhibition. Compared to the vibrational mode of a completely neutral molecule in alkaline solution, the vibrational mode of the Tripelennamine aminopyridine chromophore at neutral pH is modified, when the alkyl chain is protonated.
In vivo studyTripleennamine HCl (intravenous injection) causes the central nervous system of standing horses to become very alert, anxious and uncomfortable, they lift their heads and tighten their neck muscles with excessive rapid movement of eyes and ears, biting, sucking, rapidly waving their tails and stamping their forelimbs, and turning over the ground. The hemoglobin concentration of standing horses increased significantly after tripleennamine HCl treatment. Tripleennamine HCl (intravenous) significantly increased the mixed venous blood O 2 pressure and hemoglobin-O 2 saturation in standing horses, while increasing the O 2 content in arterial and mixed venous blood, but the gradient of O 2 concentration in arterial to mixed venous blood was not significantly affected. Tripleennamine HCl (0.5 mg/kg I. V.) had terminal elimination half-lives of 2.39 and 2.08 H in horses and camels, respectively, and total body clearance rates of 0.97 and 0.84 L/h/kg, respectively. The steady-state distribution volumes were 2.87 and 1.69 L/kg, respectively, and the central compartment volumes in these two pharmacokinetic models were 1.75 and 1.06 L/kg, respectively.

Ahistamin - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany3
RTECSUS3150000
HS Code2933399090
ToxicityLD50 in mice (mg/kg): 47 i.p. (Walker)
Ahistamin
Supplier List
Shanghai Macklin Biochemical Co., Ltd
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Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: Tripelennamine hydrochloride Visit Supplier Webpage Request for quotation
CAS: 154-69-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Amole Biotechnology Co., Ltd.
Spot supply
Product Name: Tripelennaminehydrochloride Request for quotation
CAS: 154-69-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Tripelennamine Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 154-69-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: Tripelennamine hydrochloride Visit Supplier Webpage Request for quotation
CAS: 154-69-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: TRIPELENNAMINE HYDROCHLORIDE Visit Supplier Webpage Request for quotation
CAS: 154-69-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: tripelennamine hydrochloride Request for quotation
CAS: 154-69-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Tripelennamine Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 154-69-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
Ahistamin
疫霜净
氮化硅粉末
5-Chlorovaleroyl chloride
(±)-扁桃酸
40843-73-0
15022-16-9
16205-90-6
6-Methoxy-1H-indazoL
Δ-癸内酯
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