Acotiamide
N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide
CAS: 185106-16-5
Molecular Formula: C21H30N4O5S
Acotiamide - Names and Identifiers
| Name | N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide |
| Synonyms | Acofide AcotiaMide Acotiamide ACOTIAMIDUM Acotiamide formate salt N-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide 4-Thiazolecarboxamide, N-[2-[bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]- N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydrochloride N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide |
| CAS | 185106-16-5 |
| InChI | InChI=1/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27) |
Acotiamide - Physico-chemical Properties
| Molecular Formula | C21H30N4O5S |
| Molar Mass | 450.55 |
| Density | 1.246±0.06 g/cm3(Predicted) |
| pKa | 7.38±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.591 |
Acotiamide - Introduction
N-{2-[bis (1-methyllethyl) amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide, also known as bromotropin or Kraft, is a synthetic steroid hormone. It has anti-inflammatory, anti-allergic and immunosuppressive effects.
N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide is commonly used in the medical field, for the treatment of various inflammatory diseases, such as asthma, allergic rhinitis, eczema, rheumatoid arthritis, etc. It can reduce inflammatory symptoms by inhibiting the migration and release of leukocytes during the inflammatory reaction and inhibiting the production of inflammatory cell mediators.
N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1, the preparation of 3-thiazole-4-carboxamide is mainly obtained by synthetic methods. One of the common methods is to react cortisone with bromoacetate to generate N-{2-[bis (1-methyllethyl) amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide.
When using N-{2-[bis (1-methyllethyl) amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide requires some safety information. Long-term or excessive use can cause some side effects, such as skin thinning, increased blood pressure, suppression of the immune system, increased risk of infection. As the usage time increases, someone may develop dependency. In addition, N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide is also not suitable for certain groups of people, such as pregnant women, lactating women, adolescents, etc., should be used under the guidance of a doctor.
N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide is commonly used in the medical field, for the treatment of various inflammatory diseases, such as asthma, allergic rhinitis, eczema, rheumatoid arthritis, etc. It can reduce inflammatory symptoms by inhibiting the migration and release of leukocytes during the inflammatory reaction and inhibiting the production of inflammatory cell mediators.
N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1, the preparation of 3-thiazole-4-carboxamide is mainly obtained by synthetic methods. One of the common methods is to react cortisone with bromoacetate to generate N-{2-[bis (1-methyllethyl) amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide.
When using N-{2-[bis (1-methyllethyl) amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide requires some safety information. Long-term or excessive use can cause some side effects, such as skin thinning, increased blood pressure, suppression of the immune system, increased risk of infection. As the usage time increases, someone may develop dependency. In addition, N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide is also not suitable for certain groups of people, such as pregnant women, lactating women, adolescents, etc., should be used under the guidance of a doctor.
Last Update：2024-04-09 20:52:54
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View History
Acotiamide
EOS-61674
草酸铯
2,2-dihydroxybutanedioic acid
867-44-7
3401-36-3
640-18-6
70415-85-9
18503-89-4
1074-85-7
EOS-61674
草酸铯
2,2-dihydroxybutanedioic acid
867-44-7
3401-36-3
640-18-6
70415-85-9
18503-89-4
1074-85-7