Acitretin
Etretin
CAS: 55079-83-9
Molecular Formula: C21H26O3
Acitretin - Names and Identifiers
| Name | Etretin |
| Synonyms | Etretin acitretin ACITRETIN Soriatane SORIATANE Neotigason Acritretin NEOTIGASON Neotigason, Soriatane 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid (all-e)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraen (ALL-E)-9-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-3,7-DIMETHYL-2,4,6,8-NONATETRAENOIC ACID (2Z,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid |
| CAS | 55079-83-9 |
| EINECS | 259-474-4 |
| InChI | InChI=1/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12- |
Acitretin - Physico-chemical Properties
| Molecular Formula | C21H26O3 |
| Molar Mass | 326.43 |
| Density | 1.1348 (rough estimate) |
| Melting Point | 228-230°C |
| Boling Point | 404.46°C (rough estimate) |
| Flash Point | 180.3°C |
| Solubility | Almost insoluble in water, soluble in tetrahydrofuran, slightly soluble in acetone and ethanol (96%), very slightly soluble in cyclohexane |
| Vapor Presure | 1.08E-11mmHg at 25°C |
| Appearance | powder |
| Maximum wavelength(λmax) | ['352nm(MeOH)(lit.)'] |
| Merck | 14,112 |
| pKa | 4.72±0.33(Predicted) |
| Storage Condition | -20°C |
| Stability | LIGHT SENSITIVE |
| Sensitive | Photosensitivity |
| Refractive Index | 1.4700 (estimate) |
| MDL | MFCD00866632 |
| Physical and Chemical Properties | Crystallization from hexane, melting point 228-230 °c. Acute toxicity LD50 mice by intraperitoneal injection (mg/kg):>4000(1 day),700(10 days),700(20 days). |
| Use | For the treatment of psoriasis and other intractable skin diseases |
Acitretin - Risk and Safety
| Risk Codes | R61 - May cause harm to the unborn child R36/38 - Irritating to eyes and skin. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | RA8460000 |
| FLUKA BRAND F CODES | 8-10-21 |
| HS Code | 2918992090 |
| Hazard Class | 9 |
| Packing Group | III |
| Toxicity | LD50 i.p. in mice (mg/kg): >4000 (1 day), 700 (10 days), 700 (20 days) (Bollag, 1978) |
Acitretin - Standard
Authoritative Data Verified Data
This product is all-trans -9-(4-methoxy-2, 3, 6-trimethylphenyl)-3, 7-dimethyl-2, 4,6, 8-nontetraenoic acid. The content of C21H2603 shall be between 98.5% and 102.0% based on the dry product.
Last Update：2024-01-02 23:10:35
Acitretin - Trait
Authoritative Data Verified Data
- This product is yellow crystalline powder; Odorless; Unstable in light.
- This product is dissolved in N,N-dimethylformamide, slightly soluble in dimethyl sulfoxide, very slightly soluble in ethanol, almost insoluble in water.
Last Update：2022-01-01 13:31:46
Acitretin - Differential diagnosis
Authoritative Data Verified Data
- take about 5mg of this product, add 5ml of N,N-dimethylformamide to dissolve, add 1 ml of 0.5mol/L hydrochloric acid solution, add 2 drops of potassium permanganate test solution, and the purple color will fade.
- take about 5mg of this product, add about 5ml of chloroform, shake to dissolve, add 4ml of trichloromethane solution (l-10) of antimony trichloride, that is green.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1153).
Last Update：2022-01-01 13:31:47
Acitretin - Exam
Authoritative Data Verified Data
Related substances
operation in the dark. Take an appropriate amount of this product, precision weigh, add about 5ml of tetrahydrofuran to dissolve, quantitatively dilute with methanol to make a solution containing 0.25mg of acitretin a per 1 ml as the test solution; Take an appropriate amount of precision, A solution containing 0.25ug of acitretin a per 1 ml was prepared by dilution with methanol and used as a control solution; 13-cis-acitretin a (impurity I), 9-cis-acitretin a (impurity II). With 13-ethyl acitretin a (impurity III) each appropriate amount of reference, precision weighing, and tetrahydrofuran about 5ml after dissolving, quantitative dilution with methanol to make each 1 ml containing impurities I 0.75ug, the solution of impurity III 0.5ug and impurity III 1.0ug shall be used as the reference solution; In addition, appropriate amounts of the reference products of impurity I, 11-cis-acitretin a (impurity IV), acitretin A, impurity II and impurity III shall be taken, after about 5ml of tetrahydrofuran is added and dissolved, the mixture is diluted with methanol to give a content of impurity I 0.75ug, impurity IV 0.5ug, avermectin a 250ug, impurity II 0.5ug and impurity III l per 1 ml. Oug's solution, as a system-suitable solution. The test shall be carried out according to the method under determination of inclusion of director, and the system applicable solution 20u1 shall be injected into the liquid chromatograph, and the chromatogram shall be recorded. The number of theoretical plates shall not be less than 5000 based on avermectin a peak, the degree of separation between adjacent chromatographic peaks shall meet the requirements. The control solution, the reference solution and the test solution were respectively injected with 20 u1, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If the chromatographic peaks in the chromatogram of the test solution are consistent with the retention time of impurity I peak, impurity II peak and impurity III peak, the peak area shall not exceed 0.3%, 0.2% and 0.4% respectively according to the external standard method; the Peak area of other single unknown impurities shall not be greater than the main peak area of the control solution (0.1% ); The total amount of all impurities shall not exceed 1.0%.
loss on drying
take this product, at 60°C under reduced pressure drying to constant weight, weight loss should not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 13:31:48
Acitretin - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with eighteen alkyl silane was used as the filler; Methanol-0.5% acetic acid solution (83:17) was used as the mobile phase; The injection temperature was the detection wavelength of 360nm. The theoretical plate number is not less than 3000 based on the acitretin a peak.
assay
operation in the dark. Take about 25mg of this product, precision weighing, add about 5ml of tetrahydrofuran, shake to dissolve, dilute with methanol to make a solution containing about 50ug of acitretin a per 1 ml, 20u1 was injected into the liquid chromatograph accurately, and the chromatogram was recorded. An appropriate amount of acitretin a reference substance was taken and determined by the same method, and the peak area was calculated according to the external standard method.
Last Update：2022-01-01 13:31:48
Acitretin - Category
Authoritative Data Verified Data
antikeratotic agents.
Last Update：2022-01-01 13:31:49
Acitretin - Storage
Authoritative Data Verified Data
sealed and kept in cool and dark place.
Last Update：2022-01-01 13:31:49
Acitretin - Acitretin capsules
Authoritative Data Verified Data
This product contains avermectin a (C21H2603) should be 90.0% ~ 110.0% of the label amount.
trait
The content of this product is yellow granules or powder.
identification
- take an appropriate amount of the contents of this product (about equivalent to acitretin A5mg), add about 5ml of chloroform, shake to dissolve acitretin A, and add 4ml of trichloromethane solution (1-10) of triple-vaporized antimony, green.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- Content uniformity protected from light. Take 1 capsule of this product, pour the contents into the lOOml(lOmg specification) or 250ml(25mg specification) measuring flask, wash the capsule shell with N, N Dimethyl, shake to dissolve acitretin A, dilute to scale with N, N-dimethylformamide, shake well, filter, Take 5ml of continued filtrate, put it in a 100ml measuring flask, use N, dilute N-dimethylformamide to the scale, shake well, according to UV-visible spectrophotometry (General rule 0401), determine the absorbance at the wavelength of 360nm; Take the reference substance of acitretin A, precise weighing, A solution containing about 5ug per 1 ml was prepared by dissolving and quantitatively diluting with N, N-dimethylmethylamine, measured by the same method, and the content was calculated. The provisions shall be met (General rule 0941).
- dissolution rate protected from light. Take this product, according to the dissolution and release determination method (General rule 0931 second method), with 1.2% sodium dodecyl sulfate solution as the dissolution medium, the rotation speed is 75 rpm, according to the law, after 30 minutes, take 10ml of the solution, filter, take the appropriate amount of the filtrate with precision, and dilute it quantitatively with the dissolution medium to make a solution containing about 5ug per lml. According to UV-Vis spectrophotometry (General 0401), measure absorbance at the wavelength of 350nm; Take about 25mg of acitretin a control sample, weigh it accurately, put it in 50ml measuring flask, add N,N-dimethylformamide, dissolve it and dilute it to scale, shake it well, take 1ml of precision, 100ml flask, diluted with dissolution medium to scale, shake, the same method. Calculate the amount of dissolution of each grain, the limit is 60% of the label amount, should be consistent with the provisions.
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
operation in the dark. Take 20 capsules of this product, precision weighing, calculate the average loading. Take the contents, mix well, weigh an appropriate amount accurately, add about 5ml of N,N-dimethylformamide to dissolve acitretin A, and dilute with anhydrous ethyl yeast to make a solution containing about 5ug of acitretin a per 1 ml, shake, filter, take the continued filtrate as a test solution, take 20ul of precision, according to the method under the determination of the content of acitretin A, obtained.
category
Same as Avi
specification
(l)10mg (2)25mg
storage
shade, seal, and store in a cool place.
Last Update：2022-01-01 13:31:50
Supplier List
Featured ProductsSpot supply
Product Name: Acitretin Visit Supplier Webpage Request for quotationCAS: 55079-83-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Acitretin Request for quotation
CAS: 55079-83-9
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
CAS: 55079-83-9
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Multiple SpecificationsSpot supply
Product Name: Acitretin Request for quotationCAS: 55079-83-9
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Acitretin Visit Supplier Webpage Request for quotationCAS: 55079-83-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Ro 10-1670 Visit Supplier Webpage Request for quotationCAS: 55079-83-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Acitretin Visit Supplier Webpage Request for quotationCAS: 55079-83-9
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Multiple SpecificationsSpot supply
Product Name: Acitretin Visit Supplier Webpage Request for quotationCAS: 55079-83-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Acitretin Visit Supplier Webpage Request for quotationCAS: 55079-83-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Acitretin Request for quotation
CAS: 55079-83-9
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
CAS: 55079-83-9
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Multiple SpecificationsSpot supply
Product Name: Acitretin Request for quotationCAS: 55079-83-9
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Acitretin Visit Supplier Webpage Request for quotationCAS: 55079-83-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Ro 10-1670 Visit Supplier Webpage Request for quotationCAS: 55079-83-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Acitretin Visit Supplier Webpage Request for quotationCAS: 55079-83-9
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Multiple SpecificationsSpot supply
Product Name: Acitretin Visit Supplier Webpage Request for quotationCAS: 55079-83-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Acitretin
MENTHA SPICATA OIL
Cupric 8-quinolinolate
TRIPPYPHOS
CP 50144
NSC 125691
DSPE-PEG(2000) Maleimide
钡铬黄
MENTHA SPICATA OIL
Cupric 8-quinolinolate
TRIPPYPHOS
CP 50144
NSC 125691
DSPE-PEG(2000) Maleimide
钡铬黄