AcDiSol
Croscarmellose sodium
CAS: 74811-65-7
Molecular Formula:
AcDiSol - Names and Identifiers
AcDiSol - Physico-chemical Properties
| Density | Bulk density (g/cc) 0.48 |
| Melting Point | >205oC (dec.) |
| Solubility | Practically insoluble in acetone, in anhydrous ethanol and in toluene. |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
AcDiSol - Reference
| Reference Show more | 1. [IF=3.133] Kang Sha et al."Formulation optimization of solid self-microemulsifying pellets for enhanced oral bioavailability of curcumin."Pharm Dev Technol. 2021;26(5):549-558 |
AcDiSol - Standard
Authoritative Data Verified Data
This product is a cross-linked, partially carboxylated sodium salt of cellulose.
Last Update：2024-01-02 23:10:35
AcDiSol - Trait
Authoritative Data Verified Data
- This product is white or off-white powder with hygroscopicity.
- This product swells in water and forms a suspension, which is insoluble in anhydrous ethanol, ether, acetone or toluene.
Last Update：2022-01-01 11:22:09
AcDiSol - Differential diagnosis
Authoritative Data Verified Data
- take l g of this product, add 0.0004% methylene blue solution, stir, place, generate blue fibrous precipitate.
- take l g of this product, add 50ml of water, mix well, put lm l in a test tube, add water lm l and naphthol methanol solution (take l g of a-naphthol, add 25ml of anhydrous methanol, 2ml sulfuric acid was slowly added along the wall of the inclined test tube, which showed purplish red color at the interface of liquid surface.
- the solution under identification (2) was taken to show the flame reaction of the sodium salt (General 0301).
Last Update：2022-01-01 11:22:10
AcDiSol - Exam
Authoritative Data Verified Data
sedimentation volume
take 100ml plug cylinder, add 75ml water, take the product 1 .5g, add a measuring cylinder three times, each time 0. 5g, after each sample, vigorously shake, finally add water to 100ml, continue to shake until the sample is evenly dispersed in the solution, and place for 4 hours, the sedimentation volume should be 10. 0 to 30. 0ml.
acidity
take l g of this product, add 100ml of water, shake for 5 minutes, and then determine it according to law (General rule 0631). p H value should be 5.0~7 .0.
degree of substitution
take this product about l.O g, precision weighing, put 500ml plug Erlenmeyer flask, add 10% sodium chloride solution 300ml, precision plus sodium hydroxide titration solution (0. lm o l/L )2 5 m l, tamponade, place for 5 minutes, and constantly shake, add hydrochloric acid titration solution (O.lm o l/L ) 15ml and m-cresol purple indicator solution (m-cresol purple O. lg, add 0. O lm o l/L sodium hydroxide solution (13ml) was dissolved and diluted to 100ml with water to obtain 5 drops. If the solution is purple, continue to add hydrochloric acid titration solution (0. lm o l/L ), each time 1.0 m l, until the solution becomes yellow. Titrate to purple with sodium hydroxide titration solution (0.1 M o l/L).
sodium chloride and sodium glycolate
- take about 5 .0g of sodium chloride and weigh it accurately. Put it in a 250ml beaker, add 50ml of water and 5ml of 30% hydrogen peroxide solution, put it on a water bath and heat it for 20 minutes with constant stirring. Cool, add water 100ml and nitric acid 10ml, under the condition of continuous stirring, with silver nitrate titration solution (0.05mol/L) titration, silver electrode potential method to indicate the titration end point. Each l of silver nitrate titrant (0.05mol/L) corresponds to 2. 922mg of NaCl.
- sodium glycolate was protected from light. Take about 0.5g of this product, precision weighing, 100ml beaker, add 5ml of glacial acetic acid and water, stirring for 15 minutes. After slowly adding 50ml of acetone and l g of sodium chloride successively, stir for several minutes; Filter, and transfer to a 100ml measuring flask with acetone completely quantitatively, dilute to the mark with acetone, shake well, as a test solution. Take the glycolic acid which is dried under reduced pressure at room temperature for 12 hours to about 0. lg, weigh precisely, put it in a 100ml measuring flask, add water to dissolve and dilute to the scale, shake well, take 1.0, 2.0 and 3 of the above solution respectively. 0M l and 4. Add 5ml of water and 5ml of glacial acetic acid respectively into 100ml measuring flask, dilute with acetone to the scale, and use them as reference solution (1), reference solution (2) and reference solution (3). With the control solution (4). Take the test solution and the above control solution of 2.0M l, respectively, put in 25ml measuring flask, put in water bath for heating for 20 minutes, swing away acetone, take out, after cooling, add human 2,7-dihydroxynaphthalene solution (take 10mg of 2, 7-dihydroxynaphthalene, add 100ml of sulfuric acid to dissolve the solution, and then place it until the color of the solution fades and use it within 2 days) 5.0M l, after mixing, add 2, 7-dihydroxynaphthalene solution 15.0, mix. Cover the mouth of the measuring flask with aluminum foil, heat for 20 minutes in a water bath, cool, dilute to the scale with sulfuric acid, and mix well. At the same time, 2.0ml of acetone solution containing 5% water and 5% glacial acetic acid was taken as blank solution and operated in the same method. The absorbance was measured at a wavelength of 0401 NM according to UV-Vis spectrophotometry (general rule).
soluble in water
take about 10g of this product, weigh accurately, add 800ml of water, and stir for 1 minute every 10 minutes in 30 minutes. After standing for 1 hour, take 200ml of the supernatant (centrifuge if necessary) and filter it through quick filter paper under reduced pressure. Take 150ml of the filtrate and put it in a 250ml beaker with constant weight in advance, it was concentrated to dryness by heating and dried at 105°C for 4 hours.
loss on drying
take this product, dry at 105°C for 6 hours, loss of weight shall not exceed 10.0% (General rule 0831).
ignition residue
take this product l .O g, inspection according to law (General rule 0841). The remaining residue should be 14.0% to 28.0% based on the dry product.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 11:22:11
AcDiSol - Category
Authoritative Data Verified Data
pharmaceutical excipients, disintegrants and fillers.
Last Update：2022-01-01 11:22:12
AcDiSol - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:22:12
AcDiSol - Reference Information
| EPA chemical substance information | information is provided by: ofmpeb.epa.gov (external link) |
Last Update：2024-04-09 20:45:29
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