AZ191
AZ191
CAS: 1594092-37-1
Molecular Formula: C24H27N7O
AZ191 - Names and Identifiers
AZ191 - Physico-chemical Properties
| Molecular Formula | C24H27N7O |
| Molar Mass | 429.52 |
| Density | 1.29±0.1 g/cm3(Predicted) |
| Boling Point | 705.3±70.0 °C(Predicted) |
| Solubility | DMSO: soluble10mg/mL, clear |
| Appearance | powder |
| Color | , white to yellow to light brown |
| pKa | 7.76±0.42(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| In vitro study | AZ191 (0.01-60μM; 5 days) inhibits SW872 and SW982 cell lines in dose-dependent manner with IC 50 s of 3.183 μM and 1.279 μM, respectively. AZ191 (1-5 μM; 48 hours) down-regulates three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations. Cell Proliferation Assay Cell Line: SW872, SW982 liposarcoma cells Concentration: 0.01, 0.03, 0.1, 0.3, 0.6, 1, 3, 6, 10, 20, 60 μM Incubation Time: 5 days Result: Dose-dependent growth inhibition with IC 50 s of 3.183 μM and 1.279 μM for SW872 and SW982 cell lines, respectively. Western Blot Analysis Cell Line: SW872, SW982 liposarcoma cells Concentration: 1, 2, 3, 4, 5 μM Incubation Time: 48 hours Result: Down-regulated three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations. |
AZ191 - Risk and Safety
| WGK Germany | 3 |
AZ191 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.328 ml | 11.641 ml | 23.282 ml |
| 5 mM | 0.466 ml | 2.328 ml | 4.656 ml |
| 10 mM | 0.233 ml | 1.164 ml | 2.328 ml |
| 5 mM | 0.047 ml | 0.233 ml | 0.466 ml |
Last Update：2024-01-02 23:10:35
AZ191 - Reference Information
| biological activity | AZ191 is a highly selective inhibitor of DYRK1B with an IC50 value of 17 nM. |
| target | IC50: 17 nM (DYRK1B) |
| in vitro study | AZ191 (0.01-60 μ M; 5 days) inhibits SW872 and SW982 cell lines in dose-dependent manner with IC 50 s of 3.183 μ m and 1.279 μ m, respectively. AZ191 (1-5 μ m; 48 hours) down-regulates three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations. cell Proliferation Assay Cell Line: SW872, SW982 liposarcoma cells Concentration: 0.01, 0.03, 0.1, 0.3, 0.6, 1, 3, 6, 10, 20, 60 μ m Incubation time: 5 days result: dose-dependent growth inhibition with IC 50 s of 3.183 μ m and 1.279 μ m for SW872 and SW982 cell lines, respectively. Western Blot Analysis Cell Line: SW872, SW982 liposarcoma cells Concentration: 1, 2, 3, 4, 5 μ m Incubation time: 48 hours result: down-regulated three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations. |
| Cell Line: | SW872, SW982 liposarcoma cells SW872, SW982 liposarcoma cells |
| Concentration: | 0.01, 0.03, 0.1, 0.3, 0.6, 1, 3, 6, 10, 20, 60 μM 1, 2, 3, 4, 5 μM |
| Incubation Time: | 5 days 48 hours |
| Result: | Dose-dependent growth inhibition with IC 50 s of 3.183 μM and 1.279 μM for SW872 and SW982 cell lines, respectively. Down-regulated three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations. |
Last Update：2024-04-09 21:54:55
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CAS: 1594092-37-1
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