AVL292
AVL-292
CAS: 1202757-89-8
Molecular Formula: C22H22FN5O3
AVL292 - Names and Identifiers
AVL292 - Physico-chemical Properties
| Molecular Formula | C22H22FN5O3 |
| Molar Mass | 423.44 |
| Density | 1.322±0.06 g/cm3(Predicted) |
| Solubility | DMSO 85 mg/mL (200.73 mM);Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM) |
| pKa | 13.22±0.70(Predicted) |
| Storage Condition | -20℃ |
| MDL | MFCD25976876 |
| In vitro study | AVL-292 produced a dose-dependent inhibition of BTK in Ramos cells with an EC50 of 8 nM; And inhibited the downstream BCR pathway. AVL-292 by inhibiting the activity of BTK, the proliferation of B cells was further inhibited, and the EC50 was 3 nM. |
| In vivo study | In the collagen-induced mouse arthritis model, AVL-292 (3- 30 mg/kg, p.o.) dose-dependent suppression of the clinical symptoms of such inflammation, including swelling of the joints and paws and a reduction in symptoms of redness of the affected paw. |
AVL292 - Introduction
The AVL-292 is a covalently bound, orally available, and highly selective BTK inhibitor with an IC50 of less than 0.5 nM, showing at least 1400-fold selectivity over other tested kinases. Phase 1.
Last Update：2022-10-16 17:41:20
AVL292 - Reference Information
| introduction | AVL-292 is a BTK inhibitor that can be used orally through covalent bai binding and has a highly selective du. its IC50 is less than zhi0.5 nM, showing that dao is at least 1400 times more selective than other tested kinases. |
| application | AVL-292 is an effective inhibitor of Btk kinase activity, which can be used in laboratory scientific research. |
| effect | AVL-292 produced a dose-dependent inhibition of BTK in Ramos cells with an EC50 of 8 nM; And inhibited the downstream BCR pathway. AVL-292 further inhibited the proliferation of B cells by inhibiting the activity of BTK, and its EC50 was 3 nM. In the collagen-induced mouse arthritis model, AVL-292 (3- 30 mg/kg, p.o.) dose-dependently inhibited the clinical symptoms of such inflammation, including swelling of joints and claws and the reduction of red symptoms of affected claws. |
| biological activity | Spebrutinib (CC-292, AVL-292) is a highly selective BTK inhibitor that is covalently bound and can be taken orally. Its IC50 is less than 0.5 nM, showing at least 1400 times selectivity than other tested kinases. Phase 1. |
| target | TargetValue BTK (Cell-free assay) <0.5 nM |
| Target | Value |
| BTK (Cell-free assay) | <0.5 nM |
| in vitro study | AVL-292 produced dose-dependent inhibition of BTK in Ramos cells, with EC50 of 8 nM; And inhibited the downstream BCR pathway. AVL-292 further inhibited the proliferation of B cells by inhibiting the activity of BTK, and its EC50 was 3 nM. |
| in vivo study | in collagen-induced mouse arthritis model, AVL-292 (3-30mg/kg, p.o.) dose-dependently inhibited the clinical symptoms of such inflammation, including the swelling of joints and claws and the reduction of red symptoms of affected claws. |
Last Update：2024-04-09 01:59:58
Supplier List
Featured ProductsSpot supply
Product Name: AVL-292 Visit Supplier Webpage Request for quotationCAS: 1202757-89-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: N-(3-((5-Fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide Request for quotationCAS: 1202757-89-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: AVL-292 Visit Supplier Webpage Request for quotationCAS: 1202757-89-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: AVL-292; CC-292 Visit Supplier Webpage Request for quotationCAS: 1202757-89-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: AVL-292 Visit Supplier Webpage Request for quotationCAS: 1202757-89-8
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Product Name: AVL-292 Visit Supplier Webpage Request for quotation
CAS: 1202757-89-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1202757-89-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: AVL-292 Visit Supplier Webpage Request for quotationCAS: 1202757-89-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: N-(3-((5-Fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide Request for quotationCAS: 1202757-89-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: AVL-292 Visit Supplier Webpage Request for quotationCAS: 1202757-89-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: AVL-292; CC-292 Visit Supplier Webpage Request for quotationCAS: 1202757-89-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: AVL-292 Visit Supplier Webpage Request for quotationCAS: 1202757-89-8
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Product Name: AVL-292 Visit Supplier Webpage Request for quotation
CAS: 1202757-89-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1202757-89-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History