ATGLISTATIN
Atglistatin
CAS: 1469924-27-3
Molecular Formula: C17H21N3O
ATGLISTATIN - Names and Identifiers
ATGLISTATIN - Physico-chemical Properties
| Molecular Formula | C17H21N3O |
| Molar Mass | 283.37 |
| Density | 1.135±0.06 g/cm3(Predicted) |
| Boling Point | 498.6±45.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 5 mg/ml with warming) |
| Appearance | powder |
| Color | white to beige |
| pKa | 15.01±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Physical and Chemical Properties | Bioactive Atglistatin is a highly selective inhibitor of adipose triglyceride lipase (ATGL) with an IC50 of 0.7 μm. |
| Target | IC50: 0.7 μM (ATGL) |
| In vitro study | Atglistatin inhibits lipolysis in cell and organ culture by targeting ATGL and is not cytotoxic at concentrations up to 50 μm. |
| In vivo study | In vivo, Atglistatin (I. p.) dose-and time-dependently inhibited lipolysis. Oral treatment with Atglistatin resulted in dose-dependent reductions in FA and glycerol of up to 50% and 62%, respectively, and also resulted in a significant reduction in plasma TG levels (43%). In addition, Atglistatin showed significant tissue distribution, mainly accumulated in the liver and adipose tissue. |
ATGLISTATIN - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
ATGLISTATIN - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.529 ml | 17.645 ml | 35.29 ml |
| 5 mM | 0.706 ml | 3.529 ml | 7.058 ml |
| 10 mM | 0.353 ml | 1.764 ml | 3.529 ml |
| 5 mM | 0.071 ml | 0.353 ml | 0.706 ml |
Last Update：2024-01-02 23:10:35
ATGLISTATIN - Introduction
Atglistatin (abbreviated as BDMAU) is a chemical compound whose properties and uses are as follows:
Nature:
BDMAU is a colorless to pale yellow solid, soluble in organic solvents. It is a carbamic acid amide compound with high melting point and boiling point. It is relatively stable to air and light, and can be stored for a long time at room temperature. It is an organic base capable of neutralizing with acids.
Use:
BDMAU is mainly used as catalyst and additive in chemical synthesis. It can be used as a catalyst for organic synthesis reactions, such as carbonylation reactions, esterification reactions, acyl propylation reactions, etc. It can also be used as a crosslinking agent for the synthesis of polymers and resins. In addition, BDMAU is also used in the fields of dyes and medicine.
Preparation Method:
BDMAU can be prepared by reacting aniline with dimethylformamide. The specific steps of the reaction can be referred to the manual of chemical synthesis and related literature.
Safety Information:
The toxicity of BDMAU is low, but it still needs to be handled with caution. At the time of contact, direct contact with the skin and eyes should be avoided to avoid irritation or allergic reactions. During the operation, attention should be paid to protective measures, such as wearing protective glasses, gloves and lab clothes. Laboratory safety procedures should be followed and the compound should be stored and handled correctly. In case of accidental splashing or inhalation, emergency treatment should be carried out immediately and medical help should be sought.
Nature:
BDMAU is a colorless to pale yellow solid, soluble in organic solvents. It is a carbamic acid amide compound with high melting point and boiling point. It is relatively stable to air and light, and can be stored for a long time at room temperature. It is an organic base capable of neutralizing with acids.
Use:
BDMAU is mainly used as catalyst and additive in chemical synthesis. It can be used as a catalyst for organic synthesis reactions, such as carbonylation reactions, esterification reactions, acyl propylation reactions, etc. It can also be used as a crosslinking agent for the synthesis of polymers and resins. In addition, BDMAU is also used in the fields of dyes and medicine.
Preparation Method:
BDMAU can be prepared by reacting aniline with dimethylformamide. The specific steps of the reaction can be referred to the manual of chemical synthesis and related literature.
Safety Information:
The toxicity of BDMAU is low, but it still needs to be handled with caution. At the time of contact, direct contact with the skin and eyes should be avoided to avoid irritation or allergic reactions. During the operation, attention should be paid to protective measures, such as wearing protective glasses, gloves and lab clothes. Laboratory safety procedures should be followed and the compound should be stored and handled correctly. In case of accidental splashing or inhalation, emergency treatment should be carried out immediately and medical help should be sought.
Last Update：2024-04-09 15:16:34
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