ARRY-380
ARRY-380
CAS: 937263-43-9
Molecular Formula: C26H24N8O2
ARRY-380 - Names and Identifiers
ARRY-380 - Physico-chemical Properties
| Molecular Formula | C26H24N8O2 |
| Molar Mass | 480.52 |
| Density | 1.41±0.1 g/cm3(Predicted) |
| pKa | 6.61±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | ARRY-380 is a reversible, ATP-competitive inhibitor with a nanomolar inhibitory effect on ErbB2 in vitro and in cell assays. In cell experiments, ARRY-380 was 500-fold more selective for HER2 than for EGFR, and was as potent for truncated p95-HER2 as for HER2. |
| In vivo study | ARRY-380 was able to inhibit tumor growth in a variety of her2-dependent tumor xenograft models. In many mouse tumor models, such as breast tumor (BT-474, MDA-MB-453), ovarian tumor (SKOV-3), gastric cancer (N87) model, have higher activity. In BT-474 models, ARRY-380 significantly inhibited tumor growth in a dose-dependent manner and mostly regressed. |
ARRY-380 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.081 ml | 10.405 ml | 20.811 ml |
| 5 mM | 0.416 ml | 2.081 ml | 4.162 ml |
| 10 mM | 0.208 ml | 1.041 ml | 2.081 ml |
| 5 mM | 0.042 ml | 0.208 ml | 0.416 ml |
Last Update：2024-01-02 23:10:35
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Product Name: N4-(4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine Request for quotationCAS: 937263-43-9
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Multiple SpecificationsSpot supply
Product Name: Irbinitinib; ARRY-380; ONT-380 Visit Supplier Webpage Request for quotationCAS: 937263-43-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: Irbinitinib Visit Supplier Webpage Request for quotationCAS: 937263-43-9
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View History
ARRY-380
Amidosulfuric acid
100-84-5
Citric acid ammonium salt
16633-50-4
Aluminum fluoride trihydrate
2-HYDROXYPYRIDINE 1-OXIDE
5-NITROSALICYLIC ACID METHYL ESTER
1917-64-2
62406-84-2
Amidosulfuric acid
100-84-5
Citric acid ammonium salt
16633-50-4
Aluminum fluoride trihydrate
2-HYDROXYPYRIDINE 1-OXIDE
5-NITROSALICYLIC ACID METHYL ESTER
1917-64-2
62406-84-2