98603-84-0
Sialyl Lewis X
CAS: 98603-84-0
Molecular Formula: C31H52N2O23
98603-84-0 - Names and Identifiers
98603-84-0 - Physico-chemical Properties
| Molecular Formula | C31H52N2O23 |
| Molar Mass | 820.74 |
| Density | 1.66g/cm3 |
| Melting Point | 157 - 161°C |
| Boling Point | 1285.8ºC at 760mmHg |
| Flash Point | 731.4ºC |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | -20°C |
| Stability | Store in freezer |
| MDL | MFCD00270073 |
| In vitro study | Sialyl-Lewis X is a high-affinity ligand of CD62, Antibodies [mAb CSLEX (IgM; anti-sLeX)] to sLeX inhibit CD62-mediated binding of HL-60 cells to activated platelets.Liposomes containing glycolipids with the sLeX structure prevents adhesion of HL-60 cells and human neutrophils. HL-60 cell adhesion is partially inhibited (50%) by liposomes containing Lex at 5 μg/ml. However, sLeX liposomes give maximal inhibition at only 1 ug/ml. sLeX liposomes inhibits adhesion with a 10-fold higher affinity than Lex liposomes.CD62 binding of neutrophils to activated platelets is inhibited a soluble human milk oligosaccharide that contains the LeX structure. the sLeX sugar is a 30-fold more potent inhibitor than the nonsialylated Lex sugar, which requires 2 μg/ml and 54 μg/ml to achieve 50% inhibition of neutrophil adhesion, respectively. |
98603-84-0 - Risk and Safety
| WGK Germany | 3 |
98603-84-0 - Reference Information
| Biological activity | Sialyl-Lewis X (sLeX) is a salivary enzyme acidified polytetrasaccharide, which is an endogenous antigen (antigen). Sialyl-Lewis X is a high affinity ligand for selectin E-, P-and L. Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibit CD62-mediated neutrophil recruitment at inflammatory sites. |
| in vitro study | Sialyl-Lewis X is a high-affinity ligand of CD62, Antibodies [mAb CSLEX (IgM; anti-sLeX)] to sLeX inhibit CD62-mediated binding of HL-60 cells to activated platelets.Liposomes containing glycolipids with the sLeX structure prevents adhesion of HL-60 cells and human neutrophils. HL-60 cell adhesion is partially inhibited (50%) by liposomes containing Lex at 5 μg/ml. However, SLeX liposomes give maximal inhibition at only 1 ug/ml. sLeX liposomes inhibits adhesion with a 10-fold higher affinity than Lex liposomes.CD62 binding of neutrophils to activated platelets is inhibited a soluble human milk oligosaccharide that contains the LeX structure. the sLeX sugar is a 30-fold more potent inhibitor than the nonsialylated Lex sugar, which requires 2 μg/ml and 54 μg/ml to achieve 50% inhibition of neutrophil adhesion, respectively. |
Last Update：2024-04-09 21:54:55
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