954236-44-3

954236-44-3 - Names and Identifiers

Name	3-Oxo-1-oxa-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester
Synonyms	EOS-62192 8-Boc-3-oxo-1-oxa-8-azaspiro[4.5]decane N-Boc-3-oxo-1-oxa-8-aza-spiro[4.5]decane 3-(tert-butoxycarbonyl)-3-aza-7-oxa-spiro[5.4]decan-9-one tert-butyl 3-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 3 tert-butyl 3-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 3-Oxo-1-oxa-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester 1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-oxo-, 1,1-diMethylethyl ester
CAS	954236-44-3

954236-44-3 - Physico-chemical Properties

Molecular Formula	C13H21NO4
Molar Mass	255.31
Density	1.16
Melting Point	65-66 °C(Solv: hexane (110-54-3))
Boling Point	375.5±42.0 °C(Predicted)
pKa	-0.85±0.20(Predicted)
Storage Condition	2-8°C

954236-44-3 - Introduction

3-Oxo-1-oxa-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester is an organic compound with the chemical formula C14H25NO4. It is a kind of Spiro compound with special structure, which has a wide range of applications in chemical synthesis.

The compound is a white to yellow crystalline solid, soluble in common organic solvents such as dimethylformamide and dichloromethane. It is a stable compound and does not decompose easily.

3-Oxo-1-oxa-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester is widely used as an intermediate in organic synthesis. It can be reacted by deprotection (removal of the Boc Group) to give its corresponding spirocyclic acid, or by reduction to give the corresponding spirocyclic alcohol. These intermediates can be further used in the synthesis of other organic compounds, such as drug synthesis, natural product synthesis, etc.

The method for preparing 3-Oxo-1-oxa-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester is relatively complicated and generally involves a multi-step reaction. A common method is by reacting the corresponding morphine compound with a quaternary ammonium salt, followed by an oxylation reaction, and finally the introduction of a Boc protecting group.

regarding safety, 3-Oxo-1-oxa-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester has no obvious risk when used under normal laboratory conditions. However, as chemicals, the handling and storage should strictly comply with the relevant safety regulations. When used, it is necessary to wear appropriate protective equipment and operate in a well-ventilated area. If you have any questions or unexpected situations, please ask the relevant professionals for help.

Last Update：2024-04-09 21:54:55