940929-33-9
SB743921
CAS: 940929-33-9
Molecular Formula: C31H34Cl2N2O3
940929-33-9 - Names and Identifiers
940929-33-9 - Physico-chemical Properties
| Molecular Formula | C31H34Cl2N2O3 |
| Molar Mass | 553.51926 |
| Solubility | H2O: soluble5mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | -20°C |
| In vitro study | SB 743921 has K I values of 0.1 nM and 0.12 nM for human and murine KSP, respectively, and K I values of greater than 70 μm for the other Kinks MKLP1 and kin2. SB 743921 blocks the assembly of a functional mitotic spindle, thus blocking cells during mitosis and subsequently leading to cell necrosis. SB-743921 potency against ispinesib has been improved in biochemical and cellular experiments, respectively. |
| In vivo study | SB-743921 can effectively inhibit P388 leukemia in vivo. Unlike taxanes, SB-743921 had a significant effect on a broad-spectrum tumor model. SB-743921 pairs of xenografted human tumors Colo205 (complete regression), MCF-7, SK-MES, H69, OVCAR-3 (complete and partial regression) and HT-29, MX-1, MDA-MB-231, A2780 (tumor growth delay) can produce growth-inhibiting activity. SB-743921 does not cause neuropathies frequently associated with tubulin. |
940929-33-9 - Risk and Safety
| WGK Germany | 3 |
940929-33-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.807 ml | 9.033 ml | 18.066 ml |
| 5 mM | 0.361 ml | 1.807 ml | 3.613 ml |
| 10 mM | 0.181 ml | 0.903 ml | 1.807 ml |
| 5 mM | 0.036 ml | 0.181 ml | 0.361 ml |
Last Update：2024-01-02 23:10:35
940929-33-9 - Reference Information
| biological activity | SB743921 is a kinesin spindle protein (KSP) inhibitor, ki is 0.1 nM and has little affinity for MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2. |
| Target | TargetValue KSP (MX1 cells) 0.06 nM KSP (Colo205 cells) 0.07 nM KSP 0.1 nM(Ki) KSP (SKOV3 cells) 0.2 nM KSP (MV522 cells) 1.7 nM |
| Target | Value |
| KSP (MX1 cells) | 0.06 nM |
| KSP (Colo205 cells) | 0.07 nM |
| KSP | 0.1 nM(Ki) |
| KSP (SKOV3 cells) | 0.2 nM |
| KSP (MV522 cells) | 1.7 nM |
| in vitro study | The K I values of SB 743921 for human and mouse KSP are 0.1 nM and 0.12 nM, respectively, for the other kinesin MKLP1 and Kin2, the K I values were greater than 70 μm. SB 743921 blocks the assembly of a functional mitotic spindle, thus blocking cells during mitosis and subsequently leading to cell necrosis. SB-743921 potency against ispinesib has been improved in biochemical and cellular experiments, respectively. |
| in vivo studies | is effective in inhibiting P388 leukemia SB-743921 in vivo. Unlike taxanes, SB-743921 had a significant effect on a broad-spectrum tumor model. SB-743921 pairs of xenografted human tumors Colo205 (complete regression), MCF-7, SK-MES, H69, OVCAR-3 (complete and partial regression) and HT-29, MX-1, MDA-MB-231, A2780 (tumor growth delay) can produce growth-inhibiting activity. SB-743921 does not cause neuropathies frequently associated with tubulin. |
Last Update：2024-04-09 21:54:55
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Mobile: +86-18621343501
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