94-63-3
PYRIDINE-2-CARBOXALDOXIME METHIODIDE
CAS: 94-63-3
Molecular Formula: C7H9IN2O
94-63-3 - Names and Identifiers
94-63-3 - Physico-chemical Properties
| Molecular Formula | C7H9IN2O |
| Molar Mass | 264.06 |
| Density | 1.7439 (estimate) |
| Melting Point | 220 °C (dec.)(lit.) |
| Boling Point | 220℃ |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Chemical properties light yellow needle crystalline powder. Melting point 225-226 ℃. The solubility in water at 25 ℃ is 48 mg/ml. It is easy to destroy in alkaline solution. |
| Use | Use is used as an antidote for poisoning of alkyl phosphate domestic drugs. The product is a cholinesterase reactivator. Antidote, for cyanide poisoning |
94-63-3 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S36 - Wear suitable protective clothing. S24 - Avoid contact with skin. |
| WGK Germany | 3 |
| RTECS | UU4375000 |
| HS Code | 29333990 |
| Toxicity | LD50 in mice (mg/kg): 140-178 i.v., 136-260 i.p., 290-340 s.c., 1500-4000 orally (Ellin, Wills) |
94-63-3 - Upstream Downstream Industry
| Raw Materials | Potassium iodide 2-Picoline Pralidoxime Chloride |
94-63-3 - Reference
| Reference Show more | 1. [IF=1.134] Guo-Ying Chen et al."On-line immobilized acetylcholinesterase microreactor based on capillary electrophoresis for the determination of organophosphorus pesticide residues."Chinese J Anal Chem. 2021 Dec;49:11 |
94-63-3 - Nature
| sensitivity | Light Sensitive |
| Merck | 13,7788 |
Last Update：2024-04-10 22:29:15
94-63-3 - Uses and synthesis methods
Relieve organophosphorus poisoning
Phosphorus iodosolution is designated as a single quaternary ammonium salt cholinesterase resurrection agent, which can relieve the nicotine-like symptoms of organophosphorus poisoning, quickly reduce muscle fibrillation and bronchospasm, and is used for the rescue of acute organophosphorus poisoning. It has a better effect on sarin, parathion, internal phosphorus, thitep, malathion, and ethion poisoning, and the effect on tabun, dichlor, it has no resurrection effect on cholinesterase inhibited by carbamate insecticides and diazinon, cimethaphos, propylamine and chlorophos.
traits
iodide phosphorus as yellow granular crystal or crystalline powder, odorless, bitter taste, easy to deteriorate when exposed to light. Soluble in water and hot ethanol, slightly soluble in ethanol. The aqueous solution is stable, and its properties are not stable enough in alkaline solution. It is easy to hydrolyze into cyanide, which is highly toxic and should not be compatible with alkaline drugs.
pharmacological action
The quaternary ammonium group can tend to the cationic site of phosphorylated cholinesterase that has lost its vitality combined with organophosphorus insecticides. Its nucleophilic group can be directly combined with the phosphorylation group of cholinesterase to separate from cholinesterase, so that cholinesterase can be restored to its original state and reappear its vitality. The compound energy effect of cholinesterase that has been "aged" by organophosphorus insecticides for more than 36 hours is very poor. No resurrection of cholinesterase inhibited by chronic organophosphorus insecticide poisoning. This product has obvious effect on nicotinic symptoms caused by organophosphorus insecticides, but has weak effect on muscarinic symptoms, and has no obvious effect on central nervous system symptoms.
features
1. The effect of restoring enzyme activity is strong, eliminating nicotinic symptoms such as muscle tremor, respiratory muscle spasm, etc., and eliminating muscarinic symptoms is poor, moderate and severe organophosphorus compound poisoning must be combined with atropine.
2. It has a poor effect on the "aging" phosphorylated cholinesterase that has been poisoned for a long time, and should be used as soon as possible.
3. It has a good effect on internal phosphorus absorption, parathion, malathion, etc., and is poor on trichlorfon and dichlorvos. It is almost ineffective on dimethoate and diazinon.
4. the body eliminates quickly and must be repeated many times.
5. due to iodine content, it is irritating and can only be injected intravenously.
indication
It has different degrees of resurrection effect on the cholinesterase activity inhibited by acute organophosphorus insecticides, and is used to rescue the poisoning of various organophosphorus insecticides. However, it has poor poisoning effects on malathion, trichlorfon, dichlorvos, dimethoate, methafluorophos, propylamine fluorophos and octopophos; it has no effect on cholinesterase inhibited by carbamate insecticides. Resurrection effect.
precautions
1. the earlier the application of this product, the better. For patients with poisoning caused by skin absorption, remove contaminated clothes while applying this product, and wash hair and skin with soap. The eyes are washed with 2.5% sodium bicarbonate solution and normal saline. Oral poisoning patients with 2.5% sodium bicarbonate solution for thorough gastric lavage. Since organophosphorus insecticides can be absorbed in the lower digestive tract, oral patients should maintain this product for at least 48-72 hours to prevent delayed absorption and aggravate poisoning or even death.
2. blood cholinesterase activity should be measured at any time during the medication process as a medication monitoring index. Blood cholinesterase is required to be maintained above 50% ~ 60%.
3. the safety of medication for pregnant and lactating women is still unclear.
4. the potential compensatory function of heart and kidney in the elderly should be reduced and the speed of intravenous injection should be slowed down.
drug interactions
1. this strain of cholinesterase reactivation agent can indirectly reduce the accumulation of acetylcholine and has obvious effect on skeletal muscle neuromuscular junction. Atropine has the effect of directly antagonizing the accumulation of acetylcholine, and has a strong effect on the autonomic nerve. The clinical effect of the combination of two drugs is significant. This product can enhance the biological effect of atropine, so the dose of atropine should be reduced when the two drugs are applied at the same time. Atropinization should be maintained for 48 hours, and then gradually reduce the dose of atropine or extend the injection time.
2. this product is easy to decompose in alkaline solution and is forbidden to be compatible with alkaline drugs.
adverse reactions
1. It can cause nausea, vomiting, increased heart rate, temporary ST segment depression and prolonged QT time in ECG.
2. too fast injection speed can cause vertigo, blurred vision, diplopia and uncoordinated movements.
3. Excess dose can inhibit cholinesterase, inhibit respiration and cause seizures.
4. Bitterness in the mouth and swelling of the parotid gland are related to iodine.
taboo
It is forbidden for patients with iodine allergy, and phospholizide chloride can be used instead.
production method
It is obtained by the replacement of phosphorus chloride. Add the same amount of water to the chlorinated phosphorus, heat and dissolve, stir and drop the saturated solution of potassium iodide, precipitate crystallization, filter, and spin dry. Then recrystallize with distilled water, and decolorize activated carbon to obtain iodide.
Last Update：2024-04-09 21:01:54
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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Spot supply
Product Name: Pralidoxime iodide Request for quotationCAS: 94-63-3
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Pralidoxime iodide Visit Supplier Webpage Request for quotationCAS: 94-63-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Pralidoxime Visit Supplier Webpage Request for quotationCAS: 94-63-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Pyridine-2-Carboxaldoxime Methiodide Visit Supplier Webpage Request for quotationCAS: 94-63-3
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Mobile: 18021002903
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View History
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Raw Materials for 94-63-3