91396-88-2
PluriSIn #1 (NSC 14613)
CAS: 91396-88-2
Molecular Formula: C12H11N3O
91396-88-2 - Names and Identifiers
| Name | PluriSIn #1 (NSC 14613) |
| Synonyms | NSC14613 NSC 14613 NSC-14613 plurisln 1 PluriSln 1 1,4-Pyridinecarboxylicacid 4-Pyridinecarboxylicacid, 2-phenylhydrazide |
| CAS | 91396-88-2 |
| EINECS | 804-702-5 |
91396-88-2 - Physico-chemical Properties
| Molecular Formula | C12H11N3O |
| Molar Mass | 213.24 |
| Density | 1.251±0.06 g/cm3(Predicted) |
| Melting Point | 177-178℃ |
| Boling Point | 335.7±15.0 °C(Predicted) |
| Solubility | DMSO: soluble15mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| pKa | 10.69±0.23(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Use | PluriSIn #1 (NSC 14613) is a stearoyl-coA desaturase 1 (SCD1) inhibitor that selectively eliminates hPSCs. |
| In vitro study | PluriSIns #1 acts on hPSCs with potent, rapid, selective cytotoxicity. PluriSIn #1 activated apoptosis is the central cell death mechanism. PluriSIn #1 acts on hPSCs, resulting in ER stress. PluriSIns #1(20 μm) induced a ~ 30% reduction in protein synthesis in hPSCs. The action of PluriSIns #1 on hPSCs induced a ~ 65% decrease in the activity of stearoyl-CoA dehydrogenase (SCD1). PluriSIns #1 (20 μm) inhibited the formation of teratomas by undifferentiated hPSCs, and PluriSIns also inhibited mPSCs and mouse embryonic development. |
91396-88-2 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
91396-88-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.69 ml | 23.448 ml | 46.896 ml |
| 5 mM | 0.938 ml | 4.69 ml | 9.379 ml |
| 10 mM | 0.469 ml | 2.345 ml | 4.69 ml |
| 5 mM | 0.094 ml | 0.469 ml | 0.938 ml |
Last Update：2024-01-02 23:10:35
91396-88-2 - Reference Information
| biological activity | PluriSIn #1 (NSC 14613) is a stearoyl-coA desaturase 1 (SCD1) inhibitor that selectively eliminates hPSCs. |
| target | TargetValue SCD1 |
| Target | Value | in vitro study | PluriSIns #1 acts on hPSCs and has strong, rapid and selective cytotoxicity. Apoptosis activated by PluriSIn #1 is the central cell death mechanism. PluriSIn #1 acts on hPSCs, causing ER stress. PluriSIns #1(20 μM) acts on hPSCs, inducing protein synthesis to decrease by ~ 30%. PluriSIns #1 acts on hPSCs to induce stearoyl-CoA dehydrogenase (SCD1) activity to decrease by ~ 65%. PluriSIns #1 (20 μM) inhibited the formation of teratoma by undifferentiated hPSCs, PluriSIns also inhibited mPSCs and inhibited mouse embryo development. |
Last Update：2024-04-10 22:29:15
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Product Name: NSC 14613 Visit Supplier Webpage Request for quotationCAS: 91396-88-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: PluriSIn #1 (NSC 14613) Visit Supplier Webpage Request for quotationCAS: 91396-88-2
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Email: 3008007409@qq.com
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