84605-18-5
Cycloastragenol
CAS: 84605-18-5
Molecular Formula: C30H50O5
84605-18-5 - Names and Identifiers
| Name | Cycloastragenol |
| Synonyms | Cyclogalagenin Cyclogalegenin Cycloastragenol cycloastragenol Cyclogalgeginin Cyclogalegigenin (3b,6a,16b,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol (3beta,6alpha,16beta,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol (3b,5ξ,6a,9ξ,10ξ,16b,17ξ,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol (3beta,5xi,6alpha,9xi,10xi,16beta,17xi,24R)-20,24-epoxy-9,19-cyclolanostane-3,6,16,25-tetrol |
| CAS | 84605-18-5 |
| InChI | InChI=1/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21+,22?,23?,26+,27-,28-,29?,30?/m0/s1 |
84605-18-5 - Physico-chemical Properties
| Molecular Formula | C30H50O5 |
| Molar Mass | 490.71 |
| Density | 1.20 |
| Melting Point | >220°C (dec.) |
| Boling Point | 617.2±55.0 °C(Predicted) |
| Specific Rotation(α) | (c, 1.15 in MeOH)+28.7 |
| Flash Point | 327.1°C |
| Solubility | Soluble in DMSO |
| Vapor Presure | 8.17E-18mmHg at 25°C |
| Appearance | Powder |
| Color | White |
| pKa | 14.57±0.29(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.582 |
| MDL | MFCD11618124 |
| Physical and Chemical Properties | Derived from legume Astragalus mongholicus Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.)Hsiao dry root |
| In vitro study | Cycloastragenol (0-10 µM; 3-6 days) increases cell growth compared to the vehicle control in HEK cultures. Cycloastragenol (0.3 µM; 5-90 mins) induces CREB phosphorylation in primary cortical neurons, total CREB expression is unaltered by CAG in both cell type.Cycloastragenol (3 µM; 6-48 hours) may promotes prosurvival signaling in neurons, increases tert mRNA expression, exhibits increased bcl2 mRNA expression. Cell Viability Assay Cell Line: HEK cells Concentration: 1 µM, 3 µM, 10 µM Incubation Time: 3-6 days Result: Doubled the cell growth at 6 days. Western Blot Analysis Cell Line: Neuronal cells Concentration: 0-3 µM Incubation Time: 5 mins, 15 mins, 30 mins, 90 mins Result: Suggested that CAG induces CREB activation in neuronal cells. Western Blot Analysis Cell Line: Neuronal cells Concentration: 0-3 µM Incubation Time: 6-48 hours Result: Increased tert, bcl2 mRNA expression. |
84605-18-5 - Reference
| Reference Show more | 1. [IF=5.064] Li Man et al."Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia."Acta Pharmacol Sin. 2020 Mar;41(8):1025-1032 |
84605-18-5 - Reference Information
| biological activity | Cycloastragenol is a natural teacyclic triterpenoid compound, which was identified as having anti-aging activity when screening astragalus extract. Cycloastragenol is an effective telomerase (telomerase) activator. Cycloastragenol also has other pharmacological effects, including anti-inflammatory and antioxidant properties. |
| target | TargetValue telomerase () |
| Target | Value |
| in vitro study | Cycloastragenol (0-10µM; 3-6 days) increases cell growth compared to the vehicle control in HEK cultures. Cycloastragenol (0.3 µM; 5-90 mins) induces CREB phosphorylation in primary cortical neurons, total CREB expression is unaltered by CAG in both cell type.Cycloastragenol (3 µM; 6-48 hours) may promotes prosurvival signaling in neurons, increases tert mRNA expression, exhibits increased bcl2 mRNA expression. Cell Viability Assay Cell Line: HEK cells Concentration: 1 µM, 3 µM, 10 µM Incubation Time: 3-6 days Result: doubled the cell growth at 6 days. Western Blot Analysis Cell Line: Neuronal cells Concentration: 0-3 µM Incubation Time: 5 mins, 15 mins, 30 mins, 90 mins Result: Suggested that CAG induces CREB activation in neuronal cells. Western Blot Analysis Cell Line: Neuronal cells Concentration: 0-3 µM Incubation Time: 6-48 hours Result: Increased tert, bcl2 mRNA expression. |
| Cell Line: | HEK cells Neuronal cells Neuronal cells |
| Concentration: | 1 µM, 3 µM, 10 µM 0-3 µM 0-3 µM |
| Incubation Time: | 3-6 days 5 mins, 15 mins, 30 mins, 90 mins 6-48 hours |
| Result: | Doubled the cell growth at 6 days. Suggested that CAG induces CREB activation in neuronal cells. Increased tert, bcl2 mRNA expression. |
| chemical properties | derived from leguminous plant mongolia astragalus Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.)Hsiao dried root |
| use | for content determination/identification/pharmacological experiments, etc. |
Last Update：2024-04-09 21:54:55
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