80741-39-5
BOC-L-3,4-Dichlorophe
CAS: 80741-39-5
Molecular Formula: C14H17Cl2NO4
80741-39-5 - Names and Identifiers
| Name | BOC-L-3,4-Dichlorophe |
| Synonyms | (S)-Boc-2-amino-3-(3 (2S)-Boc-2-amino-3-(3 BOC-L-3,4-Dichlorophe Boc-L-3,4-Dichlorophenylalanine 4-dichlorophenyl)propanoic acid Boc-3,4-Dichloro-L-phenylalanine (2S)-Boc-2-amino-3-(3,4-dichlorophenyl)propanoic acid 3,4-Dichloro-N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanine |
| CAS | 80741-39-5 |
| InChI | InChI=1/C14H17Cl2NO4/c1-14(2,3)21-13(20)17-11(12(18)19)7-8-4-5-9(15)10(16)6-8/h4-6,11H,7H2,1-3H3,(H,17,20)(H,18,19)/p-1/t11-/m0/s1 |
80741-39-5 - Physico-chemical Properties
| Molecular Formula | C14H17Cl2NO4 |
| Molar Mass | 334.2 |
| Density | 1.3859 (rough estimate) |
| Melting Point | 120°C |
| Boling Point | 478.1±45.0 °C(Predicted) |
| Specific Rotation(α) | 15 º (c=1,MeOH) |
| Flash Point | 242.9°C |
| Vapor Presure | 6.01E-10mmHg at 25°C |
| BRN | 6426101 |
| pKa | 3.75±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.6200 (estimate) |
| MDL | MFCD00273436 |
| Physical and Chemical Properties | Melting point 120°C specific rotation 15 ° (c = 1,MeOH) |
80741-39-5 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
80741-39-5 - Introduction
BOC-L-3,4-Dichlorophe is an organic compound whose chemical formula is C16H17Cl2NO4. The following is a description of the nature, use, formulation and safety information of BOC-L-3,4-Dichlorophe:
Nature:
-Appearance: White crystal or crystalline powder
-Melting point: about 125-130°C
-Solubility: Slightly soluble in water, soluble in organic solvents such as ether and dichloromethane
Use:
BOC-L-3,4-Dichlorophe is a compound that protects amino acids and is commonly used in the chemical synthesis of peptides and proteins. It can introduce a BOC protecting group by reacting with an amino acid or peptide to protect the carboxyl and amino groups in the amino acid. This protecting group can prevent side reactions during the synthesis process, maintain the stability of the amino acid, and then remove it when necessary. BOC-L-3,4-Dichlorophe can also be used for the synthesis of intermediates for peptides having specific structural activity.
Preparation Method:
BOC-L-3,4-Dichlorophe is usually prepared by reacting BOC-alanine with 3,4-dichlorobenzoic acid. During the reaction, BOC-alanine was reacted with 3,4-dichlorobenzoic acid at a lower temperature under alkaline conditions, and then purified by crystallization to obtain the target product.
Safety Information:
- BOC-L-3,4-Dichlorophe is less toxic, but care should be taken to avoid inhalation, contact with skin and ingestion. Personal protective equipment such as goggles, gloves and masks should be worn during operation.
-If accidental contact occurs, flush the affected area immediately with clean water and seek medical help.
-During storage, keep a dry, cool, well-ventilated environment away from direct sunlight and contact with incompatible substances.
Nature:
-Appearance: White crystal or crystalline powder
-Melting point: about 125-130°C
-Solubility: Slightly soluble in water, soluble in organic solvents such as ether and dichloromethane
Use:
BOC-L-3,4-Dichlorophe is a compound that protects amino acids and is commonly used in the chemical synthesis of peptides and proteins. It can introduce a BOC protecting group by reacting with an amino acid or peptide to protect the carboxyl and amino groups in the amino acid. This protecting group can prevent side reactions during the synthesis process, maintain the stability of the amino acid, and then remove it when necessary. BOC-L-3,4-Dichlorophe can also be used for the synthesis of intermediates for peptides having specific structural activity.
Preparation Method:
BOC-L-3,4-Dichlorophe is usually prepared by reacting BOC-alanine with 3,4-dichlorobenzoic acid. During the reaction, BOC-alanine was reacted with 3,4-dichlorobenzoic acid at a lower temperature under alkaline conditions, and then purified by crystallization to obtain the target product.
Safety Information:
- BOC-L-3,4-Dichlorophe is less toxic, but care should be taken to avoid inhalation, contact with skin and ingestion. Personal protective equipment such as goggles, gloves and masks should be worn during operation.
-If accidental contact occurs, flush the affected area immediately with clean water and seek medical help.
-During storage, keep a dry, cool, well-ventilated environment away from direct sunlight and contact with incompatible substances.
Last Update：2024-04-10 22:29:15
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