8-Dihydroxyflavone
7,8-Dihydroxyflavone
CAS: 38183-03-8
Molecular Formula: C15H10O4
8-Dihydroxyflavone - Names and Identifiers
8-Dihydroxyflavone - Physico-chemical Properties
| Molecular Formula | C15H10O4 |
| Molar Mass | 254.24 |
| Density | 1.443±0.06 g/cm3(Predicted) |
| Melting Point | 243-246°C |
| Boling Point | 494.4±45.0 °C(Predicted) |
| Solubility | DMSO: soluble24mg/mL |
| Appearance | solid |
| Color | Yellow or tan |
| pKa | 6.86±0.40(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week. |
| MDL | MFCD00006836 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, is derived from the dried roots of Pulsatilla chinensis (Bge.) Regel. |
| In vitro study | 7,8-DHF at 250nm specifically activates TrkB, but not TrkA or TrkC. In addition to cerebral cortical and hippocampal neurons, 7,8-DHF also protects other cells such as retinal ganglion cells (RGC) and PC12 cells from oxidative stress-induced apoptosis and cell death. Therefore, 7,8-DHF has a neuroprotective effect. |
| In vivo study | 7,8-dihydroxyflavone is a compound with biological effects. After intraperitoneal injection or oral administration to mice, 7,8-dihydroxyflavone can cross the blood-brain barrier, activation of TrkB and its downstream PI3K/Akt and MAPK. 7,8-DHF promotes viability and reduces apoptosis of cortical neurons after traumatic brain injury. 7,8-dhf was administered 3 hours after injury, and 7,8-dhf reduced tissue damage through the PI3K/Akt signaling pathway. The 7,8-DHF treatment did not induce any significant toxic effects in mice, and chronic administration was not toxic to mice. 7,8-DHF has a strong therapeutic effect on Alzheimer's disease and can inhibit obesity by activating muscle TrkB. |
8-Dihydroxyflavone - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | DJ3004000 |
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View History
8-Dihydroxyflavone
Diethyl phosphoric chloride
AKOS BC-0122
N-3
METACYCLINE
Chloroethylene polymer
Hydrazine
增白剂VBL
Hexapeptide 9
2-ISOPROPOXYETHYLAMINE
Diethyl phosphoric chloride
AKOS BC-0122
N-3
METACYCLINE
Chloroethylene polymer
Hydrazine
增白剂VBL
Hexapeptide 9
2-ISOPROPOXYETHYLAMINE