8-Azidoadenosine
8-azidoadenosine
CAS: 4372-67-2
Molecular Formula: C10H12N8O4
8-Azidoadenosine - Names and Identifiers
| Name | 8-azidoadenosine |
| Synonyms | 8-N3-ADO 8-azidoadenosine 8-AZIDOADENOSINE 8-azido-adenosin 8-Azidoadenosine Adenosine, 8-azido- 8-AZIDO-D-ADENOSINE (2R,3R,4S,5R)-2-(6-amino-8-azidopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol (2R,3R,4S,5R)-2-(6-azanyl-8-azido-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol (2R,3R,4S,5R)-2-(6-amino-8-azido-purin-9-yl)-5-methylol-tetrahydrofuran-3,4-diol (2R,3R,4S,5R)-2-(6-amino-8-azido-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol |
| CAS | 4372-67-2 |
| InChI | InChI=1/C10H12N8O4/c11-7-4-8(14-2-13-7)18(10(15-4)16-17-12)9-6(21)5(20)3(1-19)22-9/h2-3,5-6,9,19-21H,1H2,(H2,11,13,14)/t3-,5-,6-,9-/m1/s1 |
8-Azidoadenosine - Physico-chemical Properties
| Molecular Formula | C10H12N8O4 |
| Molar Mass | 308.25 |
| Melting Point | >200?C (dec.) |
| Solubility | DMSO (Sparingly), Methanol (Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | White to Light Purple |
| Storage Condition | Amber Vial, Refrigerator, Under Inert Atmosphere |
| Stability | Light Sensitive, Moisture Sensitive |
8-Azidoadenosine - Risk and Safety
| HS Code | 29389090 |
8-Azidoadenosine - Introduction
8-azidoadenosine(8-azidoadenosine) is a compound with the chemical formula C10H12N8O4, the adenine (adenosine) nucleoside base in its structure is substituted with an azide group (azide). The following is a description of the nature, use, preparation and safety information of 8-azidoadenosine:
Nature:
-Appearance: 8-azidoadenosine is a white to light yellow solid.
-Solubility: Soluble in water and some organic solvents, such as dimethyl sulfoxide (DMSO) and methanol.
Use:
-Biochemical research: 8-azidoadenosine is commonly used to study the function and interaction of biological molecules. As an active reagent, it can be used as a substrate for studying enzymes, a probe for DNA or RNA, etc.
-Biomarkers: Since azido is extremely reactive, 8-azidoadenosine can be used as a precursor for biomarkers. Combining it with different molecular structures or fluorescent markers can be used for applications such as cell imaging and drug delivery.
Preparation Method:
- 8-azidoadenosine is usually synthesized by organic synthesis methods. A commonly used synthetic method is the reaction of 3 '-O-acetic acid protected adenine with azido compounds to yield 8-azidoadenosine.
Safety Information:
-Due to the highly active and explosive azido group, it requires caution when used with 8-azidoadenosine. Direct contact with eyes and skin should be avoided and use in well-ventilated laboratory conditions should be ensured.
- 8-azidoadenosine should be stored in a dry, cool place, avoid contact with strong oxidants and flammable materials.
-Follow relevant laboratory safety practices when handling 8-azidoadenosine, including wearing appropriate protective equipment such as lab gloves, safety goggles, and lab clothes.
Nature:
-Appearance: 8-azidoadenosine is a white to light yellow solid.
-Solubility: Soluble in water and some organic solvents, such as dimethyl sulfoxide (DMSO) and methanol.
Use:
-Biochemical research: 8-azidoadenosine is commonly used to study the function and interaction of biological molecules. As an active reagent, it can be used as a substrate for studying enzymes, a probe for DNA or RNA, etc.
-Biomarkers: Since azido is extremely reactive, 8-azidoadenosine can be used as a precursor for biomarkers. Combining it with different molecular structures or fluorescent markers can be used for applications such as cell imaging and drug delivery.
Preparation Method:
- 8-azidoadenosine is usually synthesized by organic synthesis methods. A commonly used synthetic method is the reaction of 3 '-O-acetic acid protected adenine with azido compounds to yield 8-azidoadenosine.
Safety Information:
-Due to the highly active and explosive azido group, it requires caution when used with 8-azidoadenosine. Direct contact with eyes and skin should be avoided and use in well-ventilated laboratory conditions should be ensured.
- 8-azidoadenosine should be stored in a dry, cool place, avoid contact with strong oxidants and flammable materials.
-Follow relevant laboratory safety practices when handling 8-azidoadenosine, including wearing appropriate protective equipment such as lab gloves, safety goggles, and lab clothes.
Last Update：2024-04-09 21:04:16
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