746CE
3-[4-(β-ethoxyphenethyl)-1-piperazinyl]-2-methylpropiophenone dihydrochloride
CAS: 10402-53-6
Molecular Formula: C24H34Cl2N2O2
746CE - Names and Identifiers
| Name | 3-[4-(β-ethoxyphenethyl)-1-piperazinyl]-2-methylpropiophenone dihydrochloride |
| Synonyms | 746CE Eftapan Mucitux 233-872-8 NSC 317935 Eprazinone di-HCl EPRAZINONE HYDROCHLORIDE Eprazinone dihydrochloride 3-[4-(β-ethoxyphenethyl)-1-piperazinyl]-2-methylpropiophenone dihydrochloride 3-[4-(beta-ethoxyphenethyl)-1-piperazinyl]-2-methylpropiophenone dihydrochloride Propiophenone, 3-[4-(β-ethoxyphenethyl)-1-piperazinyl]-2-methyl-, dihydrochloride (8CI) 3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-one dihydrochloride 1-Propanone, 3-[4-(2-ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-, dihydrochloride |
| CAS | 10402-53-6 |
| EINECS | 233-872-8 |
| InChI | InChI=1/C24H32N2O2.2ClH/c1-3-28-23(21-10-6-4-7-11-21)19-26-16-14-25(15-17-26)18-20(2)24(27)22-12-8-5-9-13-22;;/h4-13,20,23H,3,14-19H2,1-2H3;2*1H |
746CE - Physico-chemical Properties
| Molecular Formula | C24H34Cl2N2O2 |
| Molar Mass | 453.44 |
| Melting Point | 201° (Toffel-Nadolny, Gielsdorf); mp 160° (Mauvernay) |
| Boling Point | 503.9°C at 760 mmHg |
| Flash Point | 258.5°C |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Vapor Presure | 2.8E-10mmHg at 25°C |
| Appearance | A white or almost white crystal |
| Color | White to Off-White |
| Storage Condition | Sealed in dry,Room Temperature |
| In vitro study | Eprazinone specifically displaces binding to the NK1R. Although Eprazinone displays a rather weak inhibition of [ 125 I]BH-SP binding to NK1R, at a concentration of 25 μM, and an antagonistic effect of about 30%, NK1R blockade could contribute to its mucolytic activity. |
| In vivo study | Eprazinone 2HCl is the recommended expectorant, with secretolytic, and bronchospastic properties. Eprazinone 2HCl improves lung function and arterial pO 2. Eprazinone also has antitussive and expectorant effects. Eprazinone affects bronchoalveolar lavage fluid (BAL) lipid levels and ion transport. |
746CE - Risk and Safety
| Toxicity | LD50 in mice (mg/kg): 729 orally, 38 i.v. (Vacher) |
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