7-乙基-10-羟基喜树碱中间体

7-乙基-10-羟基喜树碱中间体 - Names and Identifiers

Name	(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE
Synonyms	RUBI-006 (S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3 (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE (S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione (S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (S)- (s)-8-Ethyl-8-hydroxy-2,3,5,8-tetrahydro-6-oxa-3a-aza-cyclopenta[b]naphthalene-1,4,7-trione
CAS	110351-94-5

7-乙基-10-羟基喜树碱中间体 - Physico-chemical Properties

Molecular Formula	C13H13NO5
Molar Mass	263.25
Density	1.50±0.1 g/cm3(Predicted)
Melting Point	183-185℃ (decomposition)
Boling Point	666.6±55.0 °C(Predicted)
pKa	11.20±0.20(Predicted)
Storage Condition	2-8°C

7-乙基-10-羟基喜树碱中间体 - Risk and Safety

Hazard Class

IRRITANT

7-乙基-10-羟基喜树碱中间体 - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	3.799 ml	18.994 ml	37.987 ml
5 mM	0.76 ml	3.799 ml	7.597 ml
10 mM	0.38 ml	1.899 ml	3.799 ml
5 mM	0.076 ml	0.38 ml	0.76 ml

Last Update：2024-01-02 23:10:35

7-乙基-10-羟基喜树碱中间体 - Reference Information

Use

(S)-4-ethyl-4-hydroxy-7, 8-dihydro-1h-pyran O[3,4-F] indolizin-3, 6,10(4H)-one is a key intermediate for the synthesis of irinotecan and camptothecin analogs.

research application

camptothecin is a pentacyclic alkaloid extracted from Camptotheca acuminata by Wall et al. As an anti-cancer chemical substance, the compound quickly attracted people's attention because of its strong inhibitory activity against leukemia and other malignant tumors in animal experiments. In the total synthesis of camptothecin,(S)-4-ethyl-4-hydroxy-7, 8-dihydro-1h-pyran O[3,4-F] indolizine-3, 6, the total synthesis of 10(4H)-ketone is the focus of research.

Last Update：2024-04-10 22:30:50

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