6960-45-8
7-Nitroindole-2-carboxylic acid
CAS: 6960-45-8
Molecular Formula: C9H6N2O4
6960-45-8 - Names and Identifiers
6960-45-8 - Physico-chemical Properties
| Molecular Formula | C9H6N2O4 |
| Molar Mass | 206.15 |
| Density | 1.4588 (rough estimate) |
| Melting Point | 260-261 °C |
| Boling Point | 344.99°C (rough estimate) |
| Water Solubility | Insoluble |
| Solubility | DMSO: >20mg/mL |
| Appearance | Tan solid |
| pKa | 4.03±0.30(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.5570 (estimate) |
| MDL | MFCD00044720 |
| In vitro study | CRT0044876 significantly inhibits APE1 depurinopyrimidine endonuclease, 3-terminal phosphodiesterase and 3 '-terminal phosphoesterase activity, with selectivity for inhibition of exonuclease Family III. CRT0044876 enhances the toxicity of several compounds targeting DNA bases, resulting in accumulation of unpaired AP sites. CRT0044876 increases oxidative DNA damage by inhibiting the BER signaling pathway, thereby increasing extracellular reactive oxygen species in the acidic tumor microenvironment, leading to cell cycle inhibition and increased DNA double-strand breaks, ultimately leading to cell death. |
6960-45-8 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R21/22 - Harmful in contact with skin and if swallowed. R43 - May cause sensitization by skin contact R36 - Irritating to the eyes |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| TSCA | Yes |
| Hazard Class | IRRITANT |
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Product Name: 7-Nitroindole-2-carboxylic acid Visit Supplier Webpage Request for quotationCAS: 6960-45-8
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Email: product@acmec-e.com
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Product Name: CRT0044876 Visit Supplier Webpage Request for quotationCAS: 6960-45-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: 7-Nitroindole-2-carboxylic acid Visit Supplier Webpage Request for quotationCAS: 6960-45-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
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Product Name: 7-Nitroindole-2-carboxylic acid Visit Supplier Webpage Request for quotationCAS: 6960-45-8
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Mobile: 18021002903
QQ: 3008007409
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