68027-15-6
Pulsatillasaponin D
CAS: 68027-15-6
Molecular Formula: C47H76O17
68027-15-6 - Names and Identifiers
68027-15-6 - Physico-chemical Properties
| Molecular Formula | C47H76O17 |
| Molar Mass | 913.09614 |
| Density | 1.40±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 239-241℃ |
| Boling Point | 997.6±65.0 °C(Predicted) |
| Specific Rotation(α) | +14.9 (Py) |
| Solubility | Soluble in methanol, ethanol, sodium hydroxide aqueous solution and other solvents, insoluble in petroleum ether, ethyl acetate. |
| Appearance | White crystal |
| Color | White to Light Beige |
| pKa | 4.63±0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Sensitive | Easily absorbing moisture |
| Physical and Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Pulsatilla chinensis. |
| In vitro study | Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase. Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells. Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) . Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF. Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells. Cell Cytotoxicity Assay Cell Line: A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells. Concentration: 0.3 ng/mL to 10 μg/mL. Incubation Time: 72 h. Result: Exhibited an ED 50 value of 6.3 μg/mL for A-549 cells. |
| In vivo study | Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model. Animal Model: 2x2x2 mm 3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice. Dosage: 6.4 mg/kg. Administration: Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day. Result: Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%). |
68027-15-6 - Reference
| Reference Show more | Effects of human intestinal flora on metabolic transformation of ginsenoside Rg_3 and Pulsatilla saponin D [J]. Chinese patent medicine 2018 40(09):1902-1909. |
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View History
68027-15-6
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885272-22-0
157069-48-2
烯丙基硫脲
151793-24-7
1070773-09-9
1-(TERT-BUTYL)HYDRAZINE HYDROCHLORIDE
Fmoc-L-谷氨酸甲酯
牛蒡子苷元
64828-40-6