67424-93-5
N(^a)-Benzyloxycarbonyl-D-histidine
CAS: 67424-93-5
Molecular Formula: C14H15N3O4
67424-93-5 - Names and Identifiers
| Name | N(^a)-Benzyloxycarbonyl-D-histidine |
| Synonyms | Z-D-His-OH Z-D-His-Oh Z-D-HIS-OH Cbz-D-histidine N(ALPHA)-CBZ-D-HISTIDINE Nα-Carbobenzoxy-D-histidine Nalpha-Cbz-D-histidine Z-D-His-OH Nα-(Benzyloxycarbonyl)-D-histidine N-[(Benzyloxy)carbonyl]-D-histidine D-histidine, N-[(phenylmethoxy)carbonyl]- (R)-α-[[(Benzyloxy)carbonyl]amino]-1H-imidazole-4-propanoic acid (R)-2-(Benzyloxycarbonylamino)-3-(1H-imidazol-4-yl)propionic acid |
| CAS | 67424-93-5 |
| InChI | InChI=1/C14H15N3O4/c18-13(19)12(6-11-7-15-9-16-11)17-14(20)21-8-10-4-2-1-3-5-10/h1-5,7,9,12H,6,8H2,(H,15,16)(H,17,20)(H,18,19)/t12-/m1/s1 |
67424-93-5 - Physico-chemical Properties
| Molecular Formula | C14H15N3O4 |
| Molar Mass | 289.29 |
| Density | 1.368±0.06 g/cm3(Predicted) |
| Melting Point | 161-163°C |
| Boling Point | 616.7±55.0 °C(Predicted) |
| Flash Point | 326.8°C |
| Vapor Presure | 4.56E-16mmHg at 25°C |
| BRN | 92342 |
| pKa | 3.35±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 24 ° (C=6, 6mol/L HC |
| MDL | MFCD00067702 |
67424-93-5 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| TSCA | Yes |
| HS Code | 29339900 |
67424-93-5 - Introduction
N(^ a)-Benzyloxycarbonyl-D-histidine(N(^ a)-Benzyloxycarbonyl-D-histidine) is an organic compound with the chemical formula C₂ H₂ Nwithout. It is a white crystalline solid, soluble in acidic aqueous solutions and alcoholic solvents.
N(^ a)-Benzyloxycarbonyl-D-histidine is used as a protective amino acid in biochemical and biomedical research. It can be used in combination of protecting groups in polypeptide synthesis and solid phase synthesis. The compound also has the effect of promoting the stability of the peptide drug and prolonging its biological activity.
A method for preparing N(^ a)-Benzyloxycarbonyl-D-histidine is generally obtained by reacting D-histidine with benzylchloroformate in a suitable solvent to form a product which is purified by crystallization.
For safety information, N(^ a)-Benzyloxycarbonyl-D-histidine are chemicals and should be kept and handled properly. Safety procedures should be followed during use and appropriate protective equipment should be worn. These chemicals may cause irritation to the eyes, skin and respiratory system and direct contact should be avoided. Attention should be paid to the risk of fire and explosion. Before any use or disposal, the relevant safety information should be carefully read and observed. In case of accidental contact or ingestion, please wash immediately or seek medical assistance.
N(^ a)-Benzyloxycarbonyl-D-histidine is used as a protective amino acid in biochemical and biomedical research. It can be used in combination of protecting groups in polypeptide synthesis and solid phase synthesis. The compound also has the effect of promoting the stability of the peptide drug and prolonging its biological activity.
A method for preparing N(^ a)-Benzyloxycarbonyl-D-histidine is generally obtained by reacting D-histidine with benzylchloroformate in a suitable solvent to form a product which is purified by crystallization.
For safety information, N(^ a)-Benzyloxycarbonyl-D-histidine are chemicals and should be kept and handled properly. Safety procedures should be followed during use and appropriate protective equipment should be worn. These chemicals may cause irritation to the eyes, skin and respiratory system and direct contact should be avoided. Attention should be paid to the risk of fire and explosion. Before any use or disposal, the relevant safety information should be carefully read and observed. In case of accidental contact or ingestion, please wash immediately or seek medical assistance.
Last Update：2024-04-09 20:02:46
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