668467-91-2
LDN 57444
CAS: 668467-91-2
Molecular Formula: C17H11Cl3N2O3
668467-91-2 - Names and Identifiers
668467-91-2 - Physico-chemical Properties
| Molecular Formula | C17H11Cl3N2O3 |
| Molar Mass | 397.64 |
| Density | 1.50±0.1 g/cm3(Predicted) |
| Boling Point | 534.4±60.0 °C(Predicted) |
| Solubility | DMSO: soluble16mg/mL |
| Appearance | solid |
| Color | Yellow |
| pKa | -2.57±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week. |
| In vitro study | 50 μm LDN-57444 treatment for 24 hours inhibited 70% of the protease activity. LDN-57444 above 25 μm significantly reduced the cell survival rate, which was concentration dependent, and the cell survival rate was reduced to 61.81% at 50 μm. LDN-57444 can lead to cell death through the apoptotic pathway, by reducing the activity of the ubiquitin-proteasome system and increasing the level of highly ubiquitinated proteins, both of these can activate the unfolded protein response. LDN-57444-induced apoptosis can be triggered by activation of endoplasmic reticulum stress (ERS). |
| In vivo study | LDN-57444, the distribution of synaptophysin in the body and the morphology of the spine were significantly changed. LDN treatment resulted in a rapid decrease in UCH-L1 activity, but treatment for several hours had no effect on protease inhibition of cAMP levels. |
668467-91-2 - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
668467-91-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.515 ml | 12.574 ml | 25.148 ml |
| 5 mM | 0.503 ml | 2.515 ml | 5.03 ml |
| 10 mM | 0.251 ml | 1.257 ml | 2.515 ml |
| 5 mM | 0.05 ml | 0.251 ml | 0.503 ml |
Last Update：2024-01-02 23:10:35
668467-91-2 - Reference Information
| biological activity | LDN-57444 is a reversible and competitive proteasome inhibitor. when inhibiting UCch-L1, IC50 is 0.88 μM, which is 30 times higher than the selectivity of subtype Uch-L3. |
| in vitro study | 50 μM LDN-57444 treatment for 24 hours inhibited 70% protease activity. LDN-57444 above 25 μM significantly reduced the cell survival rate, which was concentration-dependent. At 50 μM, the cell survival rate decreased to 61.81%. LDN-57444 can lead to cell death through the apoptosis pathway, by reducing the activity of the ubiquitin proteasome system and increasing the level of highly ubiquitinated proteins, both of which can activate unfolded protein reactions. LDN-57444-induced apoptosis can be triggered by activating endoplasmic reticulum stress (ERS). |
| in vivo studies | LDN-57444 significantly change the distribution of synaptic proteins and spine morphology in vivo. LDN treatment resulted in a rapid decline in UCH-L1 activity, but treatment for several hours had no effect on protease inhibition at cAMP level. |
| target | IC50: 0.88 μM (UCH-L1), 25 μM (UCH-L3) Ki: 0.40 μM (UCH-L1) |
Last Update：2024-04-09 21:11:58
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: LDN-57444 Request for quotationCAS: 668467-91-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: LDN-57444 Visit Supplier Webpage Request for quotationCAS: 668467-91-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: LDN-57444 Visit Supplier Webpage Request for quotationCAS: 668467-91-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: LDN 57444 Visit Supplier Webpage Request for quotationCAS: 668467-91-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
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