657-27-2
L(+)-Lysine monohydrochloride
CAS: 657-27-2;10098-89-2
Molecular Formula: C6H14N2O2.HCl
657-27-2 - Names and Identifiers
657-27-2 - Physico-chemical Properties
| Molecular Formula | C6H14N2O2.HCl |
| Molar Mass | 182.65 |
| Melting Point | 263-264℃ |
| Boling Point | 311.5°C at 760 mmHg |
| Specific Rotation(α) | 21 º (C=8, 6N HCL) |
| Flash Point | 142.2°C |
| Water Solubility | 65 g/100 mL (20℃) |
| Solubility | Easily soluble in water, slightly soluble in ethanol and ether |
| Vapor Presure | 0.000123mmHg at 25°C |
| Appearance | Crystallization |
| Storage Condition | 2-8℃ |
| MDL | MFCD00064564 |
| Use | Used as pharmaceutical raw materials and food, feed additives |
657-27-2 - Risk and Safety
| Risk Codes | 34 - Causes burns |
| Safety Description | S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 1789 8/PG 3 |
657-27-2 - Upstream Downstream Industry
| Raw Materials | Ammonium sulfate Sucrose L-Glutamic acid L-Lysine Molasses L-Threonine L-ASPARTIC ACID L-Homoserine |
| Downstream Products | L-Lysine hydrochloride |
657-27-2 - Reference
| Reference Show more | 1. [IF=9.229] Jianhua Lv et al."Antifouling and Antibacterial Properties Constructed by Quaternary Ammonium and Benzyl Ester Derived from Lysine Methacrylamide."Acs Appl Mater Inter. 2019;11(28):25556–25568 2. [IF=3.398] Hao Zhang et al."α-Glucosidase-Mediated Glucometer Readout for Portable Monitoring of Acarbose and Migliol."Chemosensors. 2022 Jun;10(6):198 |
657-27-2 - Nature
Open Data Verified Data
white powder, no odor or slightly with specific odor. Soluble in water, insoluble in ethanol and ether. 1g of the product is soluble in 2.5ml of water, 10 ml of glycerol or looml of propylene glycol at 20 °c. Strong hygroscopicity. Relatively stable, but easy to agglomerate at high temperature, coloring. Stable under acidic conditions, alkaline conditions when reducing sugar is easy to decompose, and vitamin C or vitamin K3 coexistence when easy coloring.
Last Update：2025-06-10 22:55:16
657-27-2 - Preparation Method
Open Data Verified Data
Brevibacterium flavum or Corynebacterium glutamicum were used as production bacteria, and the product was obtained by fermentation.
Last Update：2025-06-07 19:20:19
657-27-2 - Standard
Authoritative Data Verified Data
This product is L-2, 6-diaminohexanoic acid hydrochloride. The content of C6H14N202 • HCl shall not be less than 98.5% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
657-27-2 - Trait
Authoritative Data Verified Data
- This product is white crystal or crystalline powder; Odorless.
- This product is soluble in water, very slightly soluble in ethanol, almost insoluble in ether.
specific rotation
take this product, precision weighing, add 6mol / L hydrochloric acid solution to dissolve and quantitatively dilute to make a solution containing about 80mg per lml, and determine according to law (General 0621), the specific rotation was 20.4 ° to 21.5 °.
Last Update：2022-01-01 15:35:17
657-27-2 - Application
Open Data Verified Data
lysine is one of the essential amino acids and an excellent food fortifier. Used in drinks, rice, flour, canned food, can improve the utilization rate of protein, so as to greatly strengthen the nutrition of food, to promote growth and development, increase appetite, reduce disease, enhance the role of physical fitness, used in canned food, the role of deodorant preservation. China's provisions can be used for processing noodles flour, biscuits and bread, the use of 1~2g/kg.
Last Update：2025-08-19 16:24:40
657-27-2 - Differential diagnosis
Authoritative Data Verified Data
- a solution containing about 0.4mg per 1 ml was prepared by adding appropriate amounts of the product and the lysine hydrochloride reference product, and dissolving and diluting with water, respectively, as the test solution and the reference solution. According to the chromatographic condition test under other amino acids, the position and color of the main spot of the test solution should be the same as that of the reference solution.
- The infrared absorption spectrum of this product should be consistent with the spectrum of the control (Spectrum set 399 figure or 1035 figure).
- identification reaction of chloride in aqueous solution of this product (General rule 0301).
Last Update：2022-01-01 15:35:18
657-27-2 - Safety
Open Data Verified Data
- although no obvious side effects, but high blood chloride, acidosis and renal insufficiency with caution.
- light shielding, sealed storage.
Last Update：2025-06-10 22:55:16
657-27-2 - Exam
Authoritative Data Verified Data
acidity
take l.Og of this product, Add 10ml of water to dissolve, and measure it according to law (General rule 0631). The pH value should be 5.0~6.0.
transmittance of solution
take 0.5g of this product, add water 10ml to dissolve, according to UV-visible spectrophotometry (General rule 0401), measure the transmittance at 430nm wavelength, not less than 98.0%.
sulfate
take l.Og of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.02% of standard potassium sulfate solution, it should not be more concentrated ().
ammonium salt
take 0.10g of this product and check it according to law (General rule 0808). Compared with the control solution made of 0.02% of standard chlorinated saddle solution, it shall not be deeper ().
other amino acids
take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 20mg per lml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to scale with water, shake, as a control solution; Take the appropriate amount of lysine hydrochloride control and arginine control, and place in the same measuring flask, water was added to dissolve and diluted to prepare a solution containing about 0.4mg each per 1ml as a system-suitable solution. According to the thin layer chromatography (General 0502) test, absorb 5ul of each of the above three solutions, respectively point on the same silica gel G thin layer plate, with N-propanol-concentrated ammonia solution (2:1) as the developing solvent, expand, dry, spray with ninhydrin in acetone solution (1-50), heat at 80°C until spots appear, and examine immediately. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. If the test solution shows impurity spots, the color should not be deeper (0.5%) than the main spot of the control solution.
loss on drying
take this product, dry at 105°C for 3 hours, loss of weight shall not exceed 0.4% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Iron Salt
take 0.50g of this product and check it according to law (General rule 0807). Compared with the control solution made of 0.003% of standard iron solution, it should not be deeper ().
Heavy metals
take 2.0g of this product, add 23ml of water to dissolve, add 2ml of acetate buffer (pH 3.5), and check according to law (General rule 0821 first law), containing heavy metals shall not exceed 10 parts per million.
arsenic salt
take 2.0g of this product, add 23ml of water to dissolve, add 5ml of hydrochloric acid, check according to law (General rule 0822 first law), should comply with the provisions (0.0001%).
bacterial endotoxin
take this product, check according to law (General 1143), each lg of lysine hydrochloride containing endotoxin should be less than 10EU. (For injection)
chlorine content
take about 0.35g of this product, precision weighing, add 20ml of water to dissolve, add 2ml of dilute acetic acid and 8~10 drops of bromophenol blue indicator solution, and use silver nitrate titration solution (0.1 mol/ L) titration to blue-purple. Each 1 ml of silver nitrate titration solution (0.1 mol/L) corresponds to 3.545mg of C1. The chlorine content shall be 19.0%-19.6% based on the dry product.
Last Update：2022-01-01 15:35:18
657-27-2 - Content determination
Authoritative Data Verified Data
take this product about 90mg, precision weighing, add anhydrous formic acid 3ml to dissolve, add glacial acetic acid 50ml and Mercury acetate test solution 10ml, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 9.133mg of C6H14N202. Hc1.
Last Update：2022-01-01 15:35:19
657-27-2 - Category
Authoritative Data Verified Data
amino acid drugs.
Last Update：2022-01-01 15:35:19
657-27-2 - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:35:19
Supplier List
Featured ProductsMultiple SpecificationsSpot supply
Product Name: L-(+)-Lysine monohydrochloride Visit Supplier Webpage Request for quotationCAS: 657-27-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: L(+)-Lysine monohydrochloride Request for quotationCAS: 657-27-2
Tel: 021-60556179
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Multiple SpecificationsSpot supply
Product Name: L(+)-Lysine monohydrochloride Request for quotationCAS: 657-27-2/10098-89-2
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Multiple SpecificationsSpot supply
Product Name: L-Lysine HCl Request for quotationCAS: 657-27-2
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Multiple SpecificationsSpot supply
Product Name: L(+)-Lysine monohydrochloride Request for quotationCAS: 657-27-2
Tel: +86-17505207175
Email: 3787852685@qq.com
Mobile: +86-17505207175
QQ: 3787852685
Wechat: chemical6666
Multiple SpecificationsSpot supply
Product Name: L(+)-Lysine monohydrochloride Request for quotationCAS: 657-27-2
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Product Name: L-Lysine hydrochloride Request for quotation
CAS: 657-27-2
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
CAS: 657-27-2
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Multiple SpecificationsSpot supply
Product Name: L-Lysine monohydrocholoride Request for quotationCAS: 657-27-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Multiple SpecificationsSpot supply
Product Name: L-Lysine monohydrocholoride Visit Supplier Webpage Request for quotationCAS: 657-27-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: L-Lysine (hydrochloride) (Standard) Visit Supplier Webpage Request for quotationCAS: 657-27-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Featured ProductsMultiple SpecificationsSpot supply
Product Name: L-(+)-Lysine monohydrochloride Visit Supplier Webpage Request for quotationCAS: 657-27-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: L(+)-Lysine monohydrochloride Request for quotationCAS: 657-27-2
Tel: 021-60556179
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Multiple SpecificationsSpot supply
Product Name: L(+)-Lysine monohydrochloride Request for quotationCAS: 657-27-2/10098-89-2
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Multiple SpecificationsSpot supply
Product Name: L-Lysine HCl Request for quotationCAS: 657-27-2
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Multiple SpecificationsSpot supply
Product Name: L(+)-Lysine monohydrochloride Request for quotationCAS: 657-27-2
Tel: +86-17505207175
Email: 3787852685@qq.com
Mobile: +86-17505207175
QQ: 3787852685
Wechat: chemical6666
Multiple SpecificationsSpot supply
Product Name: L(+)-Lysine monohydrochloride Request for quotationCAS: 657-27-2
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Product Name: L-Lysine hydrochloride Request for quotation
CAS: 657-27-2
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
CAS: 657-27-2
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Multiple SpecificationsSpot supply
Product Name: L-Lysine monohydrocholoride Request for quotationCAS: 657-27-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Multiple SpecificationsSpot supply
Product Name: L-Lysine monohydrocholoride Visit Supplier Webpage Request for quotationCAS: 657-27-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: L-Lysine (hydrochloride) (Standard) Visit Supplier Webpage Request for quotationCAS: 657-27-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
View History
Raw Materials for 657-27-2
Downstream Products for 657-27-2