6094-36-6
Bz-Glu-OH
CAS: 6094-36-6
Molecular Formula: C12H13NO5
6094-36-6 - Names and Identifiers
| Name | Bz-Glu-OH |
| Synonyms | Bz-Glu-OH BZ-GLU-OH BZO-GLU-OH Bz-L-Glu-OH BENZOYL-GLU-OH BENZOYL-L-GLUTAMIC ACID N-BENZOYL-L-GLUTAMIC ACID N-ALPHA-BENZOYL-L-GLUTAMIC ACID |
| CAS | 6094-36-6 |
| EINECS | 229-275-7 |
6094-36-6 - Physico-chemical Properties
| Molecular Formula | C12H13NO5 |
| Molar Mass | 251.24 |
| Density | 1.354±0.06 g/cm3(Predicted) |
| Melting Point | 140 °C |
| Boling Point | 562.0±40.0 °C(Predicted) |
| Appearance | Solid |
| pKa | 3.61±0.10(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 18.5 ° (C=10, 1mol/L |
| MDL | MFCD00014028 |
6094-36-6 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| Hazard Note | Irritant |
6094-36-6 - Reference Information
| introduction | N-benzyl-L-glutamic acid is an important pharmaceutical intermediate. If it is applied to anti-colorectal cancer drugs, N-[5-[N-[(3, 4-dihydro-2-methyl-4-oxo-6-quinazolinyl)-methyl]-N-Methylamino]-2-thienoyl]-L-glutamic acid (raltitrexed) synthesis. |
| preparation | in the reaction container equipped with stirrer and dropping funnel, add 3.5L of 70% potassium carbonate solution with mass fraction, reduce the solution temperature to 7 ℃, slowly add 4.1mol of L-glutamic acid (2), and control the stirring speed to 190rpm, at the same time, the two dropping funnels dropwise add p 4.15mol chloromethylstyrene soluble solution and 1800ml of sodium bisulfite solution with mass fraction of 80%, control the temperature of the solution to 19 ℃, control the reaction pH to maintain at 10, keep the stirring speed for 60min after all , add 30% oxalic acid solution with mass fraction to maintain the pH at 6, reduce the temperature of the solution to 3 ℃, stand for 30h, filter out the solid, mix the solid with 1100ml of potassium chloride solution with a mass fraction of 20%, keep the temperature of the solution at 6 ℃, continue stirring until the solid is precipitated, filtration, toluene solvent washing, dehydration of anhydrous potassium carbonate, and 782.12g of N-benzyl-L-glutamic acid with a 76% yield. |
| use | intermediate of proglumide. |
Last Update：2024-04-09 20:45:29
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