582315-72-8
BMS-265246
CAS: 582315-72-8
Molecular Formula: C18H17F2N3O2
582315-72-8 - Names and Identifiers
582315-72-8 - Physico-chemical Properties
| Molecular Formula | C18H17F2N3O2 |
| Molar Mass | 345.34 |
| Density | 1.304±0.06 g/cm3(Predicted) |
| Boling Point | 552.9±50.0 °C(Predicted) |
| pKa | 8.50±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | BMS265246 inhibited CDK4/cycD activity with an IC50 of 0.23 μm and inhibited A2780 Cytox with an IC50 of 0.76 μm. BMS265246 binds to CDK2, the inhibitory site coincides with the ATP purine binding site, and forms important hydrogen bonds with Leu83 on the protein backbone. BMS265246 potently inhibits CDK1 and cdk2. BMS265246 represents the most potent CDK/CDK2 selective analog. BMS265246 inhibited CDK4/cycD activity with an IC50 of 0.23 μm and inhibited A2780 Cytox with an IC50 of 0.76 μm. BMS265246 binds to CDK2, the inhibitory site coincides with the ATP purine binding site, and forms important hydrogen bonds with Leu83 on the protein backbone. BMS265246 potently inhibits CDK1 and cdk2. BMS265246 represents the most potent CDK/CDK2 selective analog. |
582315-72-8 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.896 ml | 14.478 ml | 28.957 ml |
| 5 mM | 0.579 ml | 2.896 ml | 5.791 ml |
| 10 mM | 0.29 ml | 1.448 ml | 2.896 ml |
| 5 mM | 0.058 ml | 0.29 ml | 0.579 ml |
Last Update：2024-01-02 23:10:35
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Product Name: BMS-265246 Visit Supplier Webpage Request for quotationCAS: 582315-72-8
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Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: BMS-265246 Visit Supplier Webpage Request for quotationCAS: 582315-72-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: BMS-265246 Visit Supplier Webpage Request for quotationCAS: 582315-72-8
Tel: 18301782025
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View History
582315-72-8
1,7-庚二醇
埃索拉唑钠
4-溴苯丙烯酸
对氟苯甲酸甲脂
Trypsin-EDTA Solution 1X
N-溴代琥珀酰亚胺
2-(2-butoxyethoxy)-1-butoxyethane
二氯二硫代磷酸丙酯
ethylenglycolmonovinylester
1,7-庚二醇
埃索拉唑钠
4-溴苯丙烯酸
对氟苯甲酸甲脂
Trypsin-EDTA Solution 1X
N-溴代琥珀酰亚胺
2-(2-butoxyethoxy)-1-butoxyethane
二氯二硫代磷酸丙酯
ethylenglycolmonovinylester