5521-55-1
5-Methylpyrazine-2-carboxylic acid
CAS: 5521-55-1
Molecular Formula: C6H6N2O2
5521-55-1 - Names and Identifiers
5521-55-1 - Physico-chemical Properties
| Molecular Formula | C6H6N2O2 |
| Molar Mass | 138.12 |
| Density | 1.3471 (rough estimate) |
| Melting Point | 167-171°C(lit.) |
| Boling Point | 253.51°C (rough estimate) |
| Flash Point | 145.2°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.000172mmHg at 25°C |
| Appearance | Crystallization |
| Color | Orange |
| BRN | 116005 |
| pKa | 3.53±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.5100 (estimate) |
| MDL | MFCD00068241 |
| Physical and Chemical Properties | Appearance: pale yellow crystals melting point 166-169°C crystals. The melting point was 168-170 °c. |
| Use | It is an intermediate of glipizide and lezhiping An intermediate of the lipid-lowering drug amoxice. |
5521-55-1 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S36 - Wear suitable protective clothing. |
| WGK Germany | 1 |
| HS Code | 29339990 |
| Hazard Note | Irritant |
5521-55-1 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| Application | 5-methylpyrazine-2-formic acid, also known as 2-methyl-5-formic acid, is an important pharmaceutical intermediate It is mainly used to prepare an important hypoglycemic drug glipizide and a new generation of long-acting lipid-lowering drug acipimox. At the same time, its derivative 2-methyl-5-pyrazinemethyl formate is also an important drug for the treatment of tuberculosis. |
| uses | intermediates of the hypolipidemic drug Amoxidus. It is the intermediate of the drug glipizide and lezhiping, the lipid-lowering drug amoxex. |
| Production method | It can be prepared by electrolytic oxidation of 2, 5-dimethyl or 2-methyl-5-(substituted) methylpyrazine. |
Last Update：2024-04-09 15:16:51
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