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53994-69-7

7-Amino-3-Chloro-3-Cephem-4-Carboxylic Acid

CAS: 53994-69-7

Molecular Formula: C7H7ClN2O3S

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53994-69-7 - Names and Identifiers

Name 7-Amino-3-Chloro-3-Cephem-4-Carboxylic Acid
Synonyms 7-ACCA
7-Amino-3-chloro cephalosporanic acid
7-AMINO-3-CHLORO CEPHALOSPORANIC ACID
7-AMINO-3-CHLORO-3-CEPHEM-4-CARBOXYLIC ACID
7-Amino-3-Chloro-3-Cephem-4-Carboxylic Acid
7-amino-3-coloro-3-cephem-4-carboxylic acid
Cefaclor Impurity 2(Cefaclor EP Impurity B)
7-amino-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
7-AMINO-3-CHLORO-8-OXO-5-THIA-1-AZA-BICYCLO-[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID
(6R,7R)-7-Amino-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic
(6S,7S)-7-ammonio-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
7-amino-3-chloro-8-oxo-,(6R,7R)-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid
(6R-trans)-7-amino-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS 53994-69-7
EINECS 258-907-4
InChI InChI=1/C7H7ClN2O3S/c8-2-1-14-6-3(9)5(11)10(6)4(2)7(12)13/h3,6H,1,9H2,(H,12,13)/t3-,6-/m0/s1

53994-69-7 - Physico-chemical Properties

Molecular FormulaC7H7ClN2O3S
Molar Mass234.66
Density1.81±0.1 g/cm3(Predicted)
Melting Point>180°C (dec.)
Boling Point498.9±45.0 °C(Predicted)
Flash Point255.5°C
Solubility Aqueous Acid (Slightly, Heated), DMSO (Slightly, Heated, Sonicated)
Vapor Presure2.61E-11mmHg at 25°C
AppearanceSolid
ColorPale Yellow
pKa1.87±0.50(Predicted)
Storage Conditionunder inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index1.735
UseUsed as cephalosporin drug intermediates

53994-69-7 - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Hazard ClassIRRITANT

53994-69-7 - Reference Information

overview 7-amino -3-chloro -3-cephalocyclic -4-carboxylic acid (abbreviated as 7-ACCA),7-ACCA is the key intermediate for the synthesis of the second-generation cephalosporin cefaclor. my country successfully developed cefaclor raw materials in the 2090 s, but the synthesis of raw materials has not yet achieved large-scale industrialization. The domestic production of cefaclor preparations mainly relies on imported foreign raw materials for repackaging. The main reason is 7-ACCA The synthesis process is not yet mature.
biological activity 7-Amino-3-chloro cephalosporanic acid (7-ACCA) is an important intermediate for the synthesis of the second generation cephalosporin cefaclor Cefaclor (HY-B0198).
use as an intermediate for cephalosporins
Last Update:2024-06-12 16:07:14
53994-69-7
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