51568-18-4
4,6-Dioxoheptanoic acid
CAS: 51568-18-4
Molecular Formula: C7H10O4
51568-18-4 - Names and Identifiers
51568-18-4 - Physico-chemical Properties
| Molecular Formula | C7H10O4 |
| Molar Mass | 158.15 |
| Density | 1.189±0.06 g/cm3(Predicted) |
| Melting Point | 66-67°C(lit.) |
| Boling Point | 318.7±17.0 °C(Predicted) |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Appearance | powder |
| Color | White to Off-White |
| pKa | 4.54±0.17(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | 4,6-Dioxoheptanoic acid (Succinylacetone, SA) is examined with regard to its ability to a) inhibit the second enzyme of the heme pathway, δ-aminolevulinic acid (ALA) dehydratase, b) lower the heme concentration, and c) inhibit cell growth of murine erythroleukemia (MEL) cells in culture. |
51568-18-4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
51568-18-4 - Reference Information
| introduction | 4, 6-dioxoheptanoic acid is an organic intermediate, which can be prepared by the reaction of acetal and acetic acid, and can be used to synthesize CEP derivatives (CEP-DPPE) of 1, 2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine, it can be used for the treatment of macular degeneration. |
| preparation | 4, 6-dioxoheptanoic acid (DOHA): dissolve acetal (240mg,1.2mmol) in AcOH/H2O(20mL,3:1,v/v) solution and stir for 4 hours at 50 ℃ under Ar protection. TLC(CH2Cl2/CH3OH10: 1) was used to monitor the reaction process. Once the reaction is complete, the solvent is removed by rotary evaporation to obtain crude 4,6-dioxoheptanoic acid (172.7mg,1.09mmol,91%). |
| biological activity | 4,6-Dioxoheptanoic acid is an effective inhibitor of heme biosynthesis. |
| target | Human Endogenous Metabolite |
| in vitro research | 4, 6-Dioxohptanoic acid (Succinylacetone, SA) is examined with regard to its ability to a) inhibit the second enzyme of the heme pathway, δ-aminolevulinic acid (ALA) dehydratase, B) lower the heme concentration, and c) inhibit cell growth of murine erythroleukemia (MEL) cells in culture. |
Last Update：2024-04-09 20:52:54
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View History
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